DRSC/TRiP Functional Genomics Resources

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Protein Alignment sw and DYNC1I1

DIOPT Version :10

Sequence 1:NP_477075.2 Gene:sw / 44160 FlyBaseID:FBgn0003654 Length:663 Species:Drosophila melanogaster
Sequence 2:NP_004402.1 Gene:DYNC1I1 / 1780 HGNCID:2963 Length:645 Species:Homo sapiens


Alignment Length:702 Identity:325/702 - (46%)
Similarity:430/702 - (61%) Gaps:115/702 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 DRKAELERKKAKLAALREEKDRRRREKEIK--DMEEAAGRIGGGAGIDKDQRKDLDEMLSSLGVA 64
            |.||||||||.:||.:||||.|:..|::.|  ||::....:...:.:|: :|::.:.:|.|:|::
Human     6 DLKAELERKKQRLAQIREEKKRKEEERKKKEADMQQKKEPVQDDSDLDR-KRRETEALLQSIGIS 69

  Fly    65 PVSEVLSSLSSV------------NSMTSDNSNTQTPDASLQATVNGQSGGKKQPL--------- 108
            |...::..|..:            ..|:..:.:..||     :....|..|...||         
Human    70 PEPPLVQPLHFLTWDTCYFHYLVPTPMSPSSKSVSTP-----SEAGSQDSGDLGPLTRTLQWDTD 129

  Fly   109 -----------------NLSVYNVQATNIPPKETLVYTKQTQTTSTGGGNGDVLSCHSSPLSGYM 156
                             .|.|..|...:..|:|.:.|:|:|||                      
Human   130 PSVLQLQSDSELGRRLHKLGVSKVTQVDFLPREVVSYSKETQT---------------------- 172

  Fly   157 EDWWRPRKAHATDYYDEYNLNPGLEWEDEFTDDEESSLQNLGNGFTSKLPPGYLTHGLPTVKDVA 221
                 |...|.::             |||  :|||.....:|..                     
Human   173 -----PLATHQSE-------------EDE--EDEEMVESKVGQD--------------------- 196

  Fly   222 PAITPLEIK-KETEVKK-EVNELSEEQKQMIILSENFQRFVVRAGRVIERALSENVDIYTDYIGG 284
               :.||.: |:.|||: ...||:||:||.|:.||.|..|..|..|||||||:|:.||:.||.|.
Human   197 ---SELENQDKKQEVKEAPPRELTEEEKQQILHSEEFLIFFDRTIRVIERALAEDSDIFFDYSGR 258

  Fly   285 GDSEEANDERSHARLSLNRVFYDERWSKNRCITSMDWSTHFPELVVGSYHNNEESPNEPDGVVMV 349
            ...|:..|.::.|.||.||.||||.|||:|.:|.||||..:|||:|.||:|||::|:|||||.:|
Human   259 ELEEKDGDVQAGANLSFNRQFYDEHWSKHRVVTCMDWSLQYPELMVASYNNNEDAPHEPDGVALV 323

  Fly   350 WNTKFKKSTPEDVFHCQSAVMSTCFAKFNPNLILGGTYSGQIVLWDNRVQKRTPIQRTPLSAAAH 414
            ||.||||:|||.||||||:|||.|||:|:|||::||||||||||||||..:|||:||||||||||
Human   324 WNMKFKKTTPEYVFHCQSSVMSVCFARFHPNLVVGGTYSGQIVLWDNRSHRRTPVQRTPLSAAAH 388

  Fly   415 THPVYCLQMVGTQNAHNVISISSDGKLCSWSLDMLSQPQDTLELQQRQSKAIAITSMAFPANEIN 479
            ||||||:.:||||||||:|::|:|||:|||||||||.||:::||...:||.:|:|.||||..::|
Human   389 THPVYCVNVVGTQNAHNLITVSTDGKMCSWSLDMLSTPQESMELVYNKSKPVAVTGMAFPTGDVN 453

  Fly   480 SLVMGSEDGYVYSASRHGLRSGVNEVYERHLGPITGISTHYNQLSPDFGHLFLTSSIDWTIKLWS 544
            :.|:|||:|.||:|.|||.::|:.||:|.|.||:|||:.|......||.|||:|||.|||:|||:
Human   454 NFVVGSEEGTVYTACRHGSKAGIGEVFEGHQGPVTGINCHMAVGPIDFSHLFVTSSFDWTVKLWT 518

  Fly   545 LKDTKPLYSFEDNSDYVMDVAWSPVHPALFAAVDGSGRLDLWNLNQDTEVPTASIVVAGAPALNR 609
            .|..|||||||||:|||.||.||||||||||.|||.|||||||||.||||||||:.:.||.||||
Human   519 TKHNKPLYSFEDNADYVYDVMWSPVHPALFACVDGMGRLDLWNLNNDTEVPTASVAIEGASALNR 583

  Fly   610 VSWTPSGLHVCIGDEAGKLYVYDVAENLAQPSRDEWSRFNTHLSEIKMNQSD 661
            |.|..:|..|.:||..|:::||||.| ||.|..|||:||...|.||:.|::|
Human   584 VRWAQAGKEVAVGDSEGRIWVYDVGE-LAVPHNDEWTRFARTLVEIRANRAD 634

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
swNP_477075.2 Dynein_IC2 105..135 CDD:463291 11/55 (20%)
WD40 316..632 CDD:475233 209/315 (66%)
WD40 repeat 316..365 CDD:293791 32/48 (67%)
WD40 repeat 371..409 CDD:293791 28/37 (76%)
WD40 repeat 418..457 CDD:293791 27/38 (71%)
WD40 repeat 469..555 CDD:293791 48/85 (56%)
WD40 repeat 561..599 CDD:293791 32/37 (86%)
WD40 repeat 607..633 CDD:293791 12/25 (48%)
DYNC1I1NP_004402.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..58 22/52 (42%)
Interaction with DCTN1. /evidence=ECO:0000250 2..123 34/122 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 96..125 7/33 (21%)
Dynein_IC2 143..173 CDD:463291 10/56 (18%)
Interaction with DYNLT1. /evidence=ECO:0000269|PubMed:27502274 147..163 4/15 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 169..221 22/117 (19%)
WD 1 285..334 31/48 (65%)
WD40 repeat 291..337 CDD:293791 30/45 (67%)
WD40 <318..607 CDD:441893 193/288 (67%)
WD 2 338..378 30/39 (77%)
WD40 repeat 346..385 CDD:293791 29/38 (76%)
WD 3 387..428 31/40 (78%)
WD40 repeat 393..434 CDD:293791 28/40 (70%)
WD 4 437..477 21/39 (54%)
WD40 repeat 442..481 CDD:293791 20/38 (53%)
WD 5 482..527 25/44 (57%)
WD40 repeat 488..529 CDD:293791 24/40 (60%)
WD 6 530..570 33/39 (85%)
WD40 repeat 535..573 CDD:293791 32/37 (86%)
WD 7 576..615 21/39 (54%)
WD40 repeat 581..607 CDD:293791 12/25 (48%)

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