DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sw and prp-17

DIOPT Version :9

Sequence 1:	NP_477075.2	Gene:	sw / 44160	FlyBaseID:	FBgn0003654	Length:	663	Species:	Drosophila melanogaster
Sequence 2:	NP_492851.1	Gene:	prp-17 / 172999	WormBaseID:	WBGene00018625	Length:	567	Species:	Caenorhabditis elegans

Alignment Length:	623	Identity:	114/623 - (18%)
Similarity:	218/623 - (34%)	Gaps:	159/623 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 LSSLSSVNSMTSDNSNTQTPDASLQATVNGQSGGKKQPLNLSVYNVQATNIPPKETLVYTKQTQT 134
            :.:|.:.....|::|:   .|||:.....|:|....:...::..:|::.: ..::..:...:|:.
Worm     1 MDALQAYGGSDSEHSD---DDASMDQVAKGKSSTLLERAIVTAPDVESKS-AIRQVAIVDPKTKE 61

  Fly   135 TSTGGGNGDVLSCHSSPLSGYMEDWWRPRKAHATDYYDEYNLNPGLEWEDEFTDDEE-SSLQNLG 198
            ..:......:....|.|::.:..:..|.:|...|.:.:..:||       ||..:.: .|...||
Worm    62 IKSNPKFDQLFKPESGPVNHFKSEQQRSQKNTLTGFVEPAHLN-------EFHFNRQIRSFDTLG 119

  Fly   199 NGFTSKLPPGYLTHGLPTVK--DVAPAITPLEIKK-----------------------------E 232
            .........| .||.:..||  :....::..|.||                             |
Worm   120 YAQNPTAESG-TTHFVGDVKKAEAEKGVSLFESKKTGGEKRKRVRNDDSADIDGYTGPWSRFIDE 183

  Fly   233 TEVKKEVNELSEEQKQMIILSENFQRFVVRAGRVIERALSENVDIYTDYIGGGDSEEANDERSHA 297
            ..|.|...||.::..:::...:...|...:.....|:...|:..::.        :||.|.:..:
Worm   184 KTVAKPTPELQKQMDEIVKKRQEKSRRFKKEKEDSEQMAEESSTLHL--------KEAEDYQGRS 240

  Fly   298 RL---SLNRVFYDERWSKNRCITSMDWSTHFPELVVGSYHNNEESPNEPDGVVMVWNTKFKKSTP 359
            .|   |...|...|.:...||..        |:.:|.:|..:.:..|     .:.|   |.||.
Worm   241 FLVPPSFTGVNLREDYVPERCFV--------PKKLVHTYRGHNKGVN-----FLQW---FPKSA- 288

  Fly   360 EDVFHCQSAVMSTCFAKFNPNLILGGTYSGQIVLWDNRVQKRTPIQRTPLSAAAHTHPV--YCLQ 422
                                :|.|..:...:|.||:  |..|..:.||   .|.|..||  ....
Worm   289 --------------------HLFLSCSMDTKIKLWE--VYDRQRVVRT---YAGHKLPVREVAFN 328

  Fly   423 MVGTQNAHNVISISSDGKLCSWSLDMLSQPQDTLELQQR-QSKAIAITSMAFPANEINSL-VMGS 485
            ..||:    .:|.|.|..:..|.       .:|.:::|| .:..:.......|.::.|.: ::|.
Worm   329 NEGTE----FLSASFDRYVKLWD-------TETGQVKQRFHTGHVPYCLKYHPDDDKNHMFLVGM 382

  Fly   486 EDGYVYSASRHGLRSG-VNEVYERHLGPITGISTHYNQLSPDFGHLFLTSSIDWTIKLWSLK--- 546
            ::..:.   :...||| :.:.|:|||..:..|:..      |....|.::|.|.::::|..:
Worm   383 QNKKII---QWDSRSGEIVQEYDRHLQAVNSITFF------DKNRRFASTSDDKSVRIWEWEIPV 438

  Fly   547 DTK----------PLYSFEDNSDYV----MDVAWSPVHPALFAAVDGSGRLDLWNLNQDTEVPTA 597
            |||          |..:...|..:|    ||                 .|:.|:.|..|....:.
Worm   439 DTKLIQNVGLHAIPTMTKSPNDKWVVGQCMD-----------------NRIVLFQLVDDKLRFSK 486

  Fly   598 SIVVAGAPALN---RVSWTPSGLHVCIGDEAGKLYVYD 632
            .....|..|..   .:.::|....:..||..|||:::|
Worm   487 KKAFRGHNAAGYACNIDFSPDQSFLISGDADGKLFIWD 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sw	NP_477075.2	Dynein_IC2	107..135	CDD:402922	2/27 (7%)
		WD40	316..632	CDD:421866	66/340 (19%)
		WD40 repeat	316..365	CDD:293791	8/48 (17%)
		WD40 repeat	371..409	CDD:293791	9/37 (24%)
		WD40 repeat	418..457	CDD:293791	8/40 (20%)
		WD40 repeat	469..555	CDD:293791	20/100 (20%)
		WD40 repeat	561..599	CDD:293791	7/41 (17%)
		WD40 repeat	607..633	CDD:293791	7/29 (24%)
prp-17	NP_492851.1	WD40	267..567	CDD:238121	66/329 (20%)
		WD40 repeat	279..317	CDD:293791	14/71 (20%)
		WD40 repeat	322..359	CDD:293791	10/47 (21%)
		WD40 repeat	364..402	CDD:293791	6/40 (15%)
		WD40 repeat	408..443	CDD:293791	9/40 (23%)
		WD40 repeat	451..491	CDD:293791	9/56 (16%)
		WD40 repeat	500..523	CDD:293791	6/22 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910