Protein Alignment sw and Dync1i1

DIOPT Version :10

• Sequence 1: NP_477075.2
• Gene: sw / 44160
• FlyBaseID: FBgn0003654
• Length: 663
• Species: Drosophila melanogaster
• Sequence 2: NP_001396540.1
• Gene: Dync1i1 / 13426
• MGIID: 107743
• Length: 645
• Species: Mus musculus
• Alignment Length: 700
• Identity: 321/700 - (45%)
• Similarity: 424/700 - (60%)
• Gaps: 111/700 - (15%)

  Fly     2 DRKAELERKKAKLAALREEKDRRRREKEIK--DMEEAAGRIGGGAGIDKDQRKDLDEMLSSLGVA 64
            |.||||||||.:||.:||||.|:..|::.|  ||::....:...:.:|: :|::.:.:|.|:|::
Mouse     6 DLKAELERKKQRLAQIREEKKRKEEERKKKEADMQQKKEPVQDDSDLDR-KRRETEALLQSIGIS 69

  Fly    65 PVSEVLSSLSSV------------NSMTSDNSNTQTPDASLQATVNGQSGGKKQPL--------- 108
            |...::..|..:            ..|:..:.:..||     :....|..|...||
Mouse    70 PEPPLVQPLHFLTWDTCYFHYLVPTPMSPSSKSVSTP-----SDAGSQDSGDLGPLTRTLQWDTD 129

  Fly   109 -----------------NLSVYNVQATNIPPKETLVYTKQTQTTSTGGGNGDVLSCHSSPLSGYM 156
                             .|.|..|...:..|:|.:.|:|:|||.         |:.|.|
Mouse   130 PSVLQLQSDSELGRRLHKLGVSKVTQVDFLPREVVSYSKETQTP---------LATHQS------ 179

  Fly   157 EDWWRPRKAHATDYYDEYNLNPGLEWEDEFTDDEESSLQNLGNGFTSKLPPGYLTHGLPTVKDVA 221
                      ..|..||..:.|.:..:.|..:.|:..       .|.:.||
Mouse   180 ----------EEDEEDEEMVEPKIGHDSELENQEKKQ-------ETKEAPP-------------- 213

  Fly   222 PAITPLEIKKETEVKKEVNELSEEQKQMIILSENFQRFVVRAGRVIERALSENVDIYTDYIGGGD 286
                              .||:||:||.|:.||.|..|..|..|||||||:|:.||:.||.|...
Mouse   214 ------------------RELTEEEKQQILHSEEFLIFFDRTIRVIERALAEDSDIFFDYSGREL 260

  Fly   287 SEEANDERSHARLSLNRVFYDERWSKNRCITSMDWSTHFPELVVGSYHNNEESPNEPDGVVMVWN 351
            .|:..|.::.|.||.||.||||.|||:|.:|.||||..:|||:|.||.|||::|:|||||.:|||
Mouse   261 EEKDGDVQAGANLSFNRQFYDEHWSKHRVVTCMDWSLQYPELMVASYSNNEDAPHEPDGVALVWN 325

  Fly   352 TKFKKSTPEDVFHCQSAVMSTCFAKFNPNLILGGTYSGQIVLWDNRVQKRTPIQRTPLSAAAHTH 416
            .||||:|||.||||||:|||.|||:|:|||::||||||||||||||..:|||:||||||||||||
Mouse   326 MKFKKTTPEYVFHCQSSVMSVCFARFHPNLVVGGTYSGQIVLWDNRSHRRTPVQRTPLSAAAHTH 390

  Fly   417 PVYCLQMVGTQNAHNVISISSDGKLCSWSLDMLSQPQDTLELQQRQSKAIAITSMAFPANEINSL 481
            ||||:.:||||||||:|::|:|||:|||||||||.||:::||...:||.:|:|.||||..::|:.
Mouse   391 PVYCVNVVGTQNAHNLITVSTDGKMCSWSLDMLSTPQESMELVYNKSKPVAVTGMAFPTGDVNNF 455

  Fly   482 VMGSEDGYVYSASRHGLRSGVNEVYERHLGPITGISTHYNQLSPDFGHLFLTSSIDWTIKLWSLK 546
            |:|||:|.||:|.|||.::|:.||:|.|.||:|||:.|......||.|||:|||.|||:|||:.|
Mouse   456 VVGSEEGTVYTACRHGSKAGIGEVFEGHQGPVTGINCHMAVGPIDFSHLFVTSSFDWTVKLWTTK 520

  Fly   547 DTKPLYSFEDNSDYVMDVAWSPVHPALFAAVDGSGRLDLWNLNQDTEVPTASIVVAGAPALNRVS 611
            ..|||||||||:|||.||.||||||||||.|||.|||||||||.||||||||:.:.||.|||||.
Mouse   521 HNKPLYSFEDNADYVYDVMWSPVHPALFACVDGMGRLDLWNLNSDTEVPTASVAIEGASALNRVR 585

  Fly   612 WTPSGLHVCIGDEAGKLYVYDVAENLAQPSRDEWSRFNTHLSEIKMNQSD 661
            |...|..|.:||..|::::|||.| ||.|..|||:||...|.||:.|::|
Mouse   586 WAQGGKEVAVGDSEGRIWIYDVGE-LAVPHNDEWTRFARTLVEIRANRAD 634

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sw	NP_477075.2	Dynein_IC2	105..135	CDD:463291	11/55 (20%)
		WD40	316..632	CDD:475233	208/315 (66%)
		WD40 repeat	316..365	CDD:293791	32/48 (67%)
		WD40 repeat	371..409	CDD:293791	28/37 (76%)
		WD40 repeat	418..457	CDD:293791	27/38 (71%)
		WD40 repeat	469..555	CDD:293791	48/85 (56%)
		WD40 repeat	561..599	CDD:293791	32/37 (86%)
		WD40 repeat	607..633	CDD:293791	11/25 (44%)
Dync1i1	NP_001396540.1	Dynein_IC2	143..173	CDD:463291	9/29 (31%)
		WD40 repeat	291..337	CDD:293791	30/45 (67%)
		WD40	<318..607	CDD:441893	192/288 (67%)
		WD40 repeat	346..385	CDD:293791	29/38 (76%)
		WD40 repeat	393..434	CDD:293791	28/40 (70%)
		WD40 repeat	442..481	CDD:293791	20/38 (53%)
		WD40 repeat	488..529	CDD:293791	24/40 (60%)
		WD40 repeat	535..573	CDD:293791	32/37 (86%)
		WD40 repeat	581..607	CDD:293791	11/25 (44%)