DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sw and Dync1i2

DIOPT Version :9

Sequence 1:	NP_477075.2	Gene:	sw / 44160	FlyBaseID:	FBgn0003654	Length:	663	Species:	Drosophila melanogaster
Sequence 2:	NP_446332.2	Gene:	Dync1i2 / 116659	RGDID:	620174	Length:	638	Species:	Rattus norvegicus

Alignment Length:	691	Identity:	328/691 - (47%)
Similarity:	443/691 - (64%)	Gaps:	104/691 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KAELERKKAKLAALREEKDRR---RREKEIKDMEEAAGRIGGGAGIDKDQRKDLDEMLSSLGVAP 65
            ||||||||.:||.:||||.|:   |::||....:|||..:...:.::| :|::.:.:|.|:|:..
  Rat     8 KAELERKKQRLAQIREEKKRKEEERKKKETDQKKEAAVSVQEESDLEK-KRREAEALLQSMGLTT 71

  Fly    66 VSEVLSSLSSV-NSMTSDNSNTQTP-DASLQATVNGQSGGK--------------------KQPL 108
            .|.::.|...| ..|:..:.:..|| :|..|.:.:|..|.:                    :.|:
  Rat    72 DSPIVFSEHWVPPPMSPSSKSVSTPSEAGSQDSGDGAVGSRTLHWDTDPSALQLHSDSDLGRGPI 136

  Fly   109 NLSVYNVQATNIPPKETLVYTKQTQTTSTGGGNGDVLSCHSSPLSGYMEDWWRPRKAHATDYYDE 173
            .|.:..:...:.||:|.:.|||:|||..|.                      :|:
  Rat   137 KLGMAKITQVDFPPREIVTYTKETQTPVTA----------------------QPK---------- 169

  Fly   174 YNLNPGLEWEDEFTDDEESSLQNLGNGFTSKLPPGYLTHGLPTVKDVAPAITPLEIKKETEVKKE 238
                     |||..:|                             |||....|:|.::|..:||:
  Rat   170 ---------EDEEEED-----------------------------DVAAPKPPVEPEEEKILKKD 196

  Fly   239 --------VNELSEEQKQMIILSENFQRFVVRAGRVIERALSENVDIYTDYIGGGDSEEANDERS 295
                    .:||:||:||.|:.||.|..|...:.|::||||||.::|:.||.|....::..:.::
  Rat   197 EENDSKAPPHELTEEEKQQILHSEEFLSFFDHSTRIVERALSEQINIFFDYSGRDLEDKEGEIQA 261

  Fly   296 HARLSLNRVFYDERWSKNRCITSMDWSTHFPELVVGSYHNNEESPNEPDGVVMVWNTKFKKSTPE 360
            .|:|||||.|:||||||:|.::.:|||:.:|||:|.||:||||:|:|||||.:|||.|:||:|||
  Rat   262 GAKLSLNRQFFDERWSKHRVVSCLDWSSQYPELLVASYNNNEEAPHEPDGVALVWNMKYKKTTPE 326

  Fly   361 DVFHCQSAVMSTCFAKFNPNLILGGTYSGQIVLWDNRVQKRTPIQRTPLSAAAHTHPVYCLQMVG 425
            .||||||||||..||||:|||::||||||||||||||..||||:||||||||||||||||:.:||
  Rat   327 YVFHCQSAVMSATFAKFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVG 391

  Fly   426 TQNAHNVISISSDGKLCSWSLDMLSQPQDTLELQQRQSKAIAITSMAFPANEINSLVMGSEDGYV 490
            ||||||:||||:|||:|||||||||.|||::||..:||||:|:|||:||..::|:.|:|||:|.|
  Rat   392 TQNAHNLISISTDGKICSWSLDMLSHPQDSMELVHKQSKAVAVTSMSFPVGDVNNFVVGSEEGSV 456

  Fly   491 YSASRHGLRSGVNEVYERHLGPITGISTHYNQLSPDFGHLFLTSSIDWTIKLWSLKDTKPLYSFE 555
            |:|.|||.::|::|::|.|.||||||..|....:.||.|||:|||.|||:|||:.|:.|||||||
  Rat   457 YTACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWTTKNNKPLYSFE 521

  Fly   556 DNSDYVMDVAWSPVHPALFAAVDGSGRLDLWNLNQDTEVPTASIVVAGAPALNRVSWTPSGLHVC 620
            ||||||.||.|||.||||||.|||.|||||||||.|||||||||.|.|.||||||.||.||..:.
  Rat   522 DNSDYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTEVPTASISVEGNPALNRVRWTHSGREIA 586

  Fly   621 IGDEAGKLYVYDVAENLAQPSRDEWSRFNTHLSEIKMNQSD 661
            :||..|::.:|||.|.:|.|..|||:||...|:||..:::|
  Rat   587 VGDSEGQIVIYDVGEQIAVPRNDEWARFGRTLAEINASRAD 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sw	NP_477075.2	Dynein_IC2	107..135	CDD:402922	10/27 (37%)
		WD40	316..632	CDD:421866	216/315 (69%)
		WD40 repeat	316..365	CDD:293791	30/48 (63%)
		WD40 repeat	371..409	CDD:293791	29/37 (78%)
		WD40 repeat	418..457	CDD:293791	30/38 (79%)
		WD40 repeat	469..555	CDD:293791	48/85 (56%)
		WD40 repeat	561..599	CDD:293791	31/37 (84%)
		WD40 repeat	607..633	CDD:293791	12/25 (48%)
Dync1i2	NP_446332.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..135		36/127 (28%)
		Interaction with DYNLT1. /evidence=ECO:0000269\|PubMed:27502274	133..165		11/31 (35%)
		Dynein_IC2	135..163	CDD:402922	10/27 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	154..209		21/124 (17%)
		WD 1	277..326		29/48 (60%)
		WD40 repeat	282..331	CDD:293791	30/48 (63%)
		WD40	329..>599	CDD:225201	188/269 (70%)
		WD 2	330..370		32/39 (82%)
		WD40 repeat	339..377	CDD:293791	30/37 (81%)
		WD 3	379..420		33/40 (83%)
		WD40 repeat	385..426	CDD:293791	31/40 (78%)
		WD 4	429..469		22/39 (56%)
		WD40 repeat	434..481	CDD:293791	24/46 (52%)
		WD 5	474..519		26/44 (59%)
		WD40 repeat	489..521	CDD:293791	20/31 (65%)
		WD40 repeat	527..565	CDD:293791	31/37 (84%)
		WD 6	568..607		19/38 (50%)
		WD40 repeat	573..599	CDD:293791	12/25 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334333
Domainoid	1	1.000	378	1.000	Domainoid score	I818
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37921
Inparanoid	1	1.050	618	1.000	Inparanoid score	I852
OMA	1	1.010	-	-		QHG54336
OrthoDB	1	1.010	-	-		D1453532at2759
OrthoFinder	1	1.000	-	-		FOG0001314
OrthoInspector	1	1.000	-	-		mtm9006
orthoMCL	1	0.900	-	-		OOG6_101571
Panther	1	1.100	-	-	LDO	PTHR12442
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X812
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770