DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10939 and PDZD7

DIOPT Version :9

Sequence 1:	NP_524712.1	Gene:	CG10939 / 44155	FlyBaseID:	FBgn0010620	Length:	296	Species:	Drosophila melanogaster
Sequence 2:	NP_001182192.1	Gene:	PDZD7 / 79955	HGNCID:	26257	Length:	1033	Species:	Homo sapiens

Alignment Length:	228	Identity:	54/228 - (23%)
Similarity:	88/228 - (38%)	Gaps:	40/228 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 TPTPPTLPPGVTKTCHIVKRPDFDGYGFNLHSEK-VKPGQFIGKVDADSPAEAAGLKEGDRILEV 72
            ||:..:...||.:..|:....|....|||:...| ...|.::.|||....||..|:|.||::|..
Human   197 TPSDTSSEDGVRRIVHLYTTSDDFCLGFNIRGGKEFGLGIYVSKVDHGGLAEENGIKVGDQVLAA 261

  Fly    73 NGVSIGSETHKQVVARIKAIANEVRLLLIDVDGKALEVKPASPPAAACNGNGSASQNGY-----E 132
            |||.....:|.|.|..:|...:  .:|.|...|:....|.            ..|:..:     .
Human   262 NGVRFDDISHSQAVEVLKGQTH--IMLTIKETGRYPAYKE------------MVSEYCWLDRLSN 312

  Fly   133 GTKQEMPGASANISSISMVSTKRSSNASSIQSGSTMNASDLDVV-------DRGIPAVAAPVAIT 190
            |..|::..||.:.||:|      |..:|:..|..::.:..:|:.       .||.....|..|:.
Human   313 GVLQQLSPASESSSSVS------SCASSAPYSSGSLPSDRMDICLGQEEPGSRGPGWGRADTAMQ 371

  Fly   191 PPPVQNGS-------KPSSPINNNTLMSTPPPP 216
            ..|...|.       :|:..:.:..:.|..|.|
Human   372 TEPDAGGRVETWCSVRPTVILRDTAIRSDGPHP 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10939	NP_524712.1	PDZ_signaling	20..101	CDD:238492	25/81 (31%)
PDZD7	NP_001182192.1	PDZ_signaling	84..164	CDD:238492
		PDZ_signaling	209..289	CDD:238492	25/81 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	323..380		13/62 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	444..464
		HN_PDZD7_like	554..630	CDD:259824
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	754..864
		PDZ_signaling	860..948	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	943..1033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900