DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10939 and Pard3b

DIOPT Version :9

Sequence 1:	NP_524712.1	Gene:	CG10939 / 44155	FlyBaseID:	FBgn0010620	Length:	296	Species:	Drosophila melanogaster
Sequence 2:	XP_006496361.1	Gene:	Pard3b / 72823	MGIID:	1919301	Length:	1238	Species:	Mus musculus

Alignment Length:	406	Identity:	78/406 - (19%)
Similarity:	137/406 - (33%)	Gaps:	127/406 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PTSP------------KTPTPPTLPP----GVTKTCHIVK---RPDFDGYGF-------NLHSEK 42
            |.||            :.|:.|:|.|    |..|....:|   :...:|.||       ::|.
Mouse   379 PASPQQSKSPRVPRLGRKPSSPSLSPLMGFGSKKNAKKIKIDLKKGPEGLGFTVVTRDSSIHG-- 441

  Fly    43 VKPGQ-FIGKVDADSPAEAAG-LKEGDRILEVNGVSIGSETHKQVVARIKAI--ANEVRLLLIDV 103
              ||. |:..:.....|...| |:.|||||||||..:...|.:::||.:::.  ...|.|::...
Mouse   442 --PGPIFVKNILPKGAAVKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETVSLVIARQ 504

  Fly   104 DGKAL--EVKPASPPAAA--------------CNGNGSASQN-GYEGTKQEMPGASANISSISMV 151
            :|..|  |:| ..|...|              .|.:|||... ..:|.|....|....|...|::
Mouse   505 EGSFLPRELK-GEPDCYALSLESSEQLTLEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSII 568

  Fly   152 -----------------------STKRSSNASSIQS--------GSTMNASDLDVV---DRGIPA 182
                                   :....||..::::        |:......|.::   :|.:..
Mouse   569 HGGAAFKDGRLRMNDQLIAVNGETLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPLEE 633

  Fly   183 VAAPVAITPPPVQNGSK------------------------------PSSPINNNTLMSTPPPPS 217
            ::...|::.|..:|..:                              ||.....|.:..:|||..
Mouse   634 LSECGALSRPGFENCQEALSTSRRNDSSILYPFGTYSPQDKRKDLLLPSDGWAENEVPPSPPPHP 698

  Fly   218 ATKAGINNNGSVYNTNGNG------TNGMTTPTTPPPPTSGYKAG-TLHLPMTAAEMRAKLASKK 275
            |.:.|:.:.......:..|      .|..|......|.....||. ::.|.....:::: ||.::
Mouse   699 ALEWGLEDFSHSSGVDSTGYFPDQHVNFRTVTPVRQPELINLKASKSMDLVPDEGKVQS-LADRR 762

  Fly   276 KYDPKNE---SVDLKK 288
            ...|..:   ::.|||
Mouse   763 SDSPGKDFGPTLGLKK 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10939	NP_524712.1	PDZ_signaling	20..101	CDD:238492	26/94 (28%)
Pard3b	XP_006496361.1	DUF3534	2..74	CDD:338230
		PDZ_signaling	236..323	CDD:238492
		PDZ	415..504	CDD:214570	25/92 (27%)
		PDZ_signaling	536..624	CDD:238492	13/87 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900