DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10939 and Dlg5

DIOPT Version :9

Sequence 1:	NP_524712.1	Gene:	CG10939 / 44155	FlyBaseID:	FBgn0010620	Length:	296	Species:	Drosophila melanogaster
Sequence 2:	XP_017171686.1	Gene:	Dlg5 / 71228	MGIID:	1918478	Length:	1931	Species:	Mus musculus

Alignment Length:	322	Identity:	74/322 - (22%)
Similarity:	125/322 - (38%)	Gaps:	82/322 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSTPTSPKTPTPPTLP----------------PGVTKTCHIVKRPDFDGYGFNLHSEKVKPGQFI 49
            :|:.:.|:| |..|||                |.|.:..|:..:...:..|.::.|.: |.|.::
Mouse  1322 LSSCSQPQT-TASTLPRIAVNPSSHGERRKDRPFVEEPRHVKVQKGSEPLGISIVSGE-KGGVYV 1384

  Fly    50 GKVDADSPAEAAGLKEGDRILEVNGVSIGSETHKQVVARIKAIANEVRLLLIDVDGKALEVKPAS 114
            .||...|.|..|||:.||::||.||:::.|.|.:|           .||::
Mouse  1385 SKVTLGSIAHQAGLEYGDQLLEFNGINLRSATEQQ-----------ARLII-------------- 1424

  Fly   115 PPAAACNGNGSASQNGYEGTKQEMPGASANISSISMVSTKRSSNASSIQSGSTMNASDLDVV--- 176
              ...|:.....:|  |.....::...|.:.|.:...:|..|:...| .:|:..:.|.:|.:
Mouse  1425 --GQQCDTITILAQ--YNPHIHQLNSHSRSSSHLDPAATPHSTLQGS-SAGTPEHPSVIDPLMEQ 1484

  Fly   177 DRGIPAVAAPVAITPPPVQNGSKPSSPINNNTLMSTPPP------PSATKAGINNNGSVYNTNGN 235
            |.| |.       |||..|:.|...|.  .:|...||.|      .|....|::..|      ||
Mouse  1485 DEG-PG-------TPPAKQSASSTRSV--GDTTKKTPDPRIVFIKKSQLDLGVHLCG------GN 1533

  Fly   236 GTNGM----TTPTTPPPPTSGYKAGTLHLPMTAAEMRAKLASK---KKYDPKNESVDLKKKF 290
             .:|:    ....:|.....|...|.|.|...:.:||::....   :...|| :|:.||.::
Mouse  1534 -LHGVFVAEVEDDSPAKGPDGLVPGDLILEYGSLDMRSRTVEDVYVEMLKPK-DSLRLKVQY 1593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10939	NP_524712.1	PDZ_signaling	20..101	CDD:238492	23/80 (29%)
Dlg5	XP_017171686.1	Takusan	129..213	CDD:368141
		Smc	<141..564	CDD:224117
		PDZ_signaling	625..712	CDD:238492
		PDZ_signaling	<741..800	CDD:238492
		PDZ	1357..1439	CDD:214570	26/111 (23%)
		dbPDZ_assoc	1437..1512	CDD:374667	20/85 (24%)
		PDZ	1513..1594	CDD:214570	19/89 (21%)
		SH3_DLG5	1610..1672	CDD:212794
		GuKc	1744..1920	CDD:214504
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900