DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10939 and Pdzd2

DIOPT Version :9

Sequence 1:	NP_524712.1	Gene:	CG10939 / 44155	FlyBaseID:	FBgn0010620	Length:	296	Species:	Drosophila melanogaster
Sequence 2:	NP_001074533.1	Gene:	Pdzd2 / 68070	MGIID:	1922394	Length:	2796	Species:	Mus musculus

Alignment Length:	439	Identity:	85/439 - (19%)
Similarity:	137/439 - (31%)	Gaps:	177/439 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 GVTKTCHIVK------------------RPDF-----------DGYGFNL----HSEKVKPGQFI 49
            |.::..||||                  ||..           .|.||::    ...:.:.|.|:
Mouse   554 GTSQEYHIVKKSTRSLSTTHVESPWRLIRPSVISIIGLYKEKGKGLGFSIAGGRDCVRGQMGIFV 618

  Fly    50 GKVDAD-SPAEAAGLKEGDRILEVNGVSIGSETHKQVVARIKAIANEVRLLLIDVDGKALEVKPA 113
            ..:..: |.||...|||||.||:|||:.|...|.::.:...|.|.:.:.:|.:.....:..:.|.
Mouse   619 KTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTKLLSPSLTPC 683

  Fly   114 SPP-------AAACNGNGSASQNG----------------------YEGTKQEMPGASANISSIS 149
            |.|       :.:.|.:|.|...|                      .|.|..:.|.....|.:..
Mouse   684 STPTHMSRSSSPSFNSSGGAPAGGGQDEGGSASLGRKAPGPKDRIVMEVTLNKEPRVGLGIGACC 748

  Fly   150 MV-----------------STKRSSNASSIQSGSTMNASDLDVVDRGIPAVAAPVAITPP-PVQ- 195
            :.                 ..|..||.|  :....:..:.::|....:..|.|.::..|| ||:
Mouse   749 LALENSPPGIYIHSLAPGSVAKMESNLS--RGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRL 811

  Fly   196 -NGSKP--------------------SSPINNNTLMSTP-PPPSATK------------------ 220
             .|..|                    |...|::..:.|| ..||..|
Mouse   812 VIGRHPNPKVSEQEMDEVIARSTYQESKEANSSPSLGTPLKSPSLAKKDSLLSESELSQYFVHDG 876

  Fly   221 ---------AGINNN---GSVYNTNGNGTNGMTTPTTPPPPTSGYK------------------A 255
                     ||..:.   ||.|.|:.:|:. :|.|       |.|:                  :
Mouse   877 QGSLSDFVVAGSEDEDHPGSGYETSEDGSL-LTVP-------SAYRETGKARANSLVTLGSQRGS 933

  Fly   256 GTLHLPMTAAE----------MRAKLASKKK---YDPKNESVDLKKKFD 291
            |.||..:|.|.          :|..|..:::   ||..:.|.|  :.||
Mouse   934 GLLHKQVTVARQASLPGSPQVLRNPLLRQRRVRCYDSNDGSDD--EDFD 980

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10939	NP_524712.1	PDZ_signaling	20..101	CDD:238492	29/114 (25%)
Pdzd2	NP_001074533.1	PDZ_signaling	335..416	CDD:238492
		PDZ_signaling	591..672	CDD:238492	23/80 (29%)
		PDZ_signaling	729..813	CDD:238492	15/85 (18%)
		PHA03307	1050..>1355	CDD:223039
		PHA03247	<1197..1562	CDD:223021
		PDZ_signaling	2581..2663	CDD:238492
		PDZ	2709..2791	CDD:214570
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900