DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10939 and Slc9a3r1

DIOPT Version :9

Sequence 1:	NP_524712.1	Gene:	CG10939 / 44155	FlyBaseID:	FBgn0010620	Length:	296	Species:	Drosophila melanogaster
Sequence 2:	NP_067605.1	Gene:	Slc9a3r1 / 59114	RGDID:	708538	Length:	356	Species:	Rattus norvegicus

Alignment Length:	385	Identity:	95/385 - (24%)
Similarity:	147/385 - (38%)	Gaps:	118/385 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSTPTSPKTPTPPTLPPGVTKTCHIVKRPDFDGYGFNLHSEKVKPGQFIGKVDADSPAEAAGLKE 65
            ||...:...|.|        :.|.:.|.|  :||||:||.||.|.||||..|:..||||.:||..
  Rat     1 MSADAAAGEPLP--------RLCCLEKGP--NGYGFHLHGEKGKVGQFIRLVEPGSPAEKSGLLA 55

  Fly    66 GDRILEVNGVSIGSETHKQVVARIKAIANEVRLLLIDVDG----------------KALEVKPAS 114
            |||::||||.::..|||:|||:||:|..|.||||::|.:.                :|.|....:
  Rat    56 GDRLVEVNGENVEKETHQQVVSRIRAALNAVRLLVVDPETDEQLKKLGVPIREELLRAQEKSEHT 120

  Fly   115 PPAAACNGNGSASQNGYEGTKQE---------------------------MPG-----------A 141
            .|.||.:...:..||..|.:..|                           .||           |
  Rat   121 EPPAAADTKKAGDQNEAEKSHLERCELRPRLCTMKKGPNGYGFNLHSDKSKPGQFIRAVDPDSPA 185

  Fly   142 SAN----------ISSISMVSTKRSSNASSIQSGSTMNASDLDVVDRGIPAVAAPVAIT------ 190
            .|:          ::.:.|...:.....|:|::|.  :.:.|.|||:..........:|
  Rat   186 EASGLRAQDRIVEVNGVCMEGKQHGDVVSAIKAGG--DEAKLLVVDKETDEFFKKCRVTPSQEHL 248

  Fly   191 ----PPPVQNGS-----------KPSSPINNNTLMSTPPPPSATKAGINNNGSVYNTNGNGTNGM 240
                |.|..||.           :|:|        .:|.|..|..|..:.:..:        |..
  Rat   249 DGPLPEPFSNGEIQKENSREALVEPAS--------ESPRPALARSASSDTSEEL--------NAQ 297

  Fly   241 TTP----TTPPPPTSGYKAGTLHLPMTAAEMRAKLASKKKYDPKNESVDLKKKFDIIQKL 296
            .:|    :|.|..||......|...::.|..:.: |.:|:...:...:|..||.::...|
  Rat   298 DSPKRHDSTEPSSTSSSSDPILDFNISLAVAKER-AHQKRSSKRAPQMDWSKKNELFSNL 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10939	NP_524712.1	PDZ_signaling	20..101	CDD:238492	44/80 (55%)
Slc9a3r1	NP_067605.1	PDZ_signaling	12..91	CDD:238492	45/88 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	113..142		8/28 (29%)
		PDZ_signaling	149..228	CDD:238492	9/80 (11%)
		EBP50_C	232..356	CDD:286142	24/140 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	265..356		19/107 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351289
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D377274at33208
OrthoFinder	1	1.000	-	-		FOG0002256
OrthoInspector	1	1.000	-	-		otm44813
orthoMCL	1	0.900	-	-		OOG6_106590
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2561
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.700