DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10939 and Tamalin

DIOPT Version :9

Sequence 1:	NP_524712.1	Gene:	CG10939 / 44155	FlyBaseID:	FBgn0010620	Length:	296	Species:	Drosophila melanogaster
Sequence 2:	NP_062391.3	Gene:	Tamalin / 56149	MGIID:	1860303	Length:	392	Species:	Mus musculus

Alignment Length:	237	Identity:	53/237 - (22%)
Similarity:	94/237 - (39%)	Gaps:	51/237 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 VKRPDFDGYGFNLHS--------EKVKPGQFIGKVDADSPAEAAGLKEGDRILEVNGVSIGSETH 82
            :::.|...:||.:.:        ::|:...|:.:|...|||:.|||..||.|..|||:::....|
Mouse   103 LEKGDNQTFGFEIQTYGLHHREEQRVEMVTFVCRVHESSPAQLAGLTPGDTIASVNGLNVEGIRH 167

  Fly    83 KQVVARIKAIANEVRLLLI---DVDGKALEVKPASPPAAACNGNGSASQNGYEGTKQEMPGASAN 144
            :::|..|||..|.:||..:   .:....||.:                   .:..||.:......
Mouse   168 REIVDIIKASGNVLRLETLYGTSIRKAELEAR-------------------LQYLKQTLYEKWGE 213

  Fly   145 ISSISMVSTKRSSNASSIQSGSTMNASDLDVVDRGIPAVAAPVAITPPPVQNGSKPSSPINNNTL 209
            ..|: ||..:|..:...::..|..:..:      .:.:......:.|     ||.|..|     |
Mouse   214 YRSL-MVQEQRLVHGLVVKDPSIYDTLE------SVRSCLYGAGLLP-----GSLPFGP-----L 261

  Fly   210 MSTPPPP--SATKAGINNNGSVYNTNGNGTNGMTTPTTPPPP 249
            ::.|...  .|.:|..:.:.:||:|...|  |......||||
Mouse   262 LAAPGSARGGARRAKGDTDDAVYHTCFFG--GAEPQALPPPP 301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10939	NP_524712.1	PDZ_signaling	20..101	CDD:238492	26/82 (32%)
Tamalin	NP_062391.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..50
		PDZ_signaling	99..184	CDD:238492	25/80 (31%)
		Interaction with PSCD3. /evidence=ECO:0000269\|PubMed:10828067	180..257		14/107 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	294..315		4/8 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810