DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10939 and GRID2IP

DIOPT Version :9

Sequence 1:	NP_524712.1	Gene:	CG10939 / 44155	FlyBaseID:	FBgn0010620	Length:	296	Species:	Drosophila melanogaster
Sequence 2:	NP_001138590.1	Gene:	GRID2IP / 392862	HGNCID:	18464	Length:	1211	Species:	Homo sapiens

Alignment Length:	371	Identity:	75/371 - (20%)
Similarity:	112/371 - (30%)	Gaps:	153/371 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PTSPKTPTPPTL---------PPGVTKTCHIVKRPDFDGYGFNLHS------EKVKPGQFIGKVD 53
            |..|..|.|...         |.|..:|..:.|  ....:||.|..      |.|.||
Human   252 PRRPDEPPPRRASLLVGGLAGPGGARRTVRVYK--GNKSFGFTLRGHGPVWIESVLPG------- 307

  Fly    54 ADSPAEAAGLKEGDRILEVNGVSIGSETHKQVVARIK------AIANEVRLLLIDVDGKAL---- 108
              |||:.|.||.|||||.:||:.:.:.:|.:||:.::      .:..|..|:....|..:|
Human   308 --SPADNAALKSGDRILFLNGLDMRNCSHDKVVSMLQGSGAMPTLVVEEGLVPFASDSDSLDSPN 370

  Fly   109 ------------EVKPAS-----------------PPA--AACNGNGSASQN------------- 129
                        |:.|:|                 ||.  ..|....|..|:
Human   371 PSSALTSLQWVAEILPSSIRVQGRTFSQQLEHLLTPPERYGVCRALESFFQHRNIDTLIVDVYPV 435

  Fly   130 ---------------------------------GY---------------EGTKQEMPGASANIS 146
                                             ||               |.|.:..|.:|...|
Human   436 LDTPAKQVLWQFIYQLLTYEEQELCQEKIACFLGYTAMTAEPEPELDLESEPTPEPQPRSSLRAS 500

  Fly   147 SISMVSTKRSSNASSIQSGSTMNASDLDVVDRGIPAVAAPVAITPPPVQNGSKPSSPINNNTLMS 211
            |:    .:||..:..:::|.:...|:...:         |:.:.|...|.|...|.|       .
Human   501 SM----CRRSLRSQGLEAGLSCGPSECPEM---------PLPLIPGERQAGDGTSLP-------E 545

  Fly   212 TPPPP--SATKAGINN--NGSVYNTNGNGTNGMTTPTTPPPP-TSG 252
            ||.|.  ||..|.:.:  |.|.....|..:....:|..|.|. |:|
Human   546 TPNPKMMSAVYAELESRLNSSFKGKMGTVSKSRASPPGPSPAVTTG 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10939	NP_524712.1	PDZ_signaling	20..101	CDD:238492	27/92 (29%)
GRID2IP	NP_001138590.1	PDZ_signaling	14..74	CDD:238492
		HN_L-delphilin-R1_like	133..212	CDD:259820
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	226..269		4/16 (25%)
		PDZ_signaling	278..353	CDD:238492	25/85 (29%)
		HN_L-delphilin-R2_like	389..468	CDD:259821	5/78 (6%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	478..502		5/23 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	525..549		8/39 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	568..600		6/24 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	618..672
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	718..783
		FH2	820..1188	CDD:280362
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900