DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10939 and GRIP1

DIOPT Version :9

Sequence 1:	NP_524712.1	Gene:	CG10939 / 44155	FlyBaseID:	FBgn0010620	Length:	296	Species:	Drosophila melanogaster
Sequence 2:	XP_016874587.1	Gene:	GRIP1 / 23426	HGNCID:	18708	Length:	1188	Species:	Homo sapiens

Alignment Length:	356	Identity:	76/356 - (21%)
Similarity:	128/356 - (35%)	Gaps:	128/356 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PPTLPPG---VTKTCHIVKRPDFDGYGF----NLHSEK----------VKPGQFIGKVDADSPAE 59
            ||....|   :.:|..:....:.:.:||    ..|.::          |:||         .||:
Human   212 PPVSVQGSSVIFRTVEVTLHKEGNTFGFVIRGGAHDDRNKSRPVVITCVRPG---------GPAD 267

  Fly    60 AAG-LKEGDRILEVNGVSIGSETHKQVVARIKAIANEVRLLLIDVDGKALE-VKPASPPAAACNG 122
            ..| :|.|||:|.|:|:.:...||.:.::.:|....|. .|||:.|...:: |..||.|...
Human   268 REGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEA-ALLIEYDVSVMDSVATASGPLLV--- 328

  Fly   123 NGSASQNGYEGTKQEMPGASANIS-SISMVSTKRSSNASSIQS--------------------GS 166
                     |..|  .||||..:: :.||...|:......|:|                    |:
Human   329 ---------EVAK--TPGASLGVALTTSMCCNKQVIVIDKIKSASIADRCGALHVGDHILSIDGT 382

  Fly   167 TM-------------NASD---LDVVDRGIPAVAAPVAITPP---PVQNGSKP---SSPINNNTL 209
            :|             |.:|   |::    :|.....:|:..|   .:|...:.   .|..:|::.
Human   383 SMEYCTLAEATQFLANTTDQVKLEI----LPHHQTRLALKGPDHVKIQRSDRQLTWDSWASNHSS 443

  Fly   210 MSTPPPPSATKAGINNNGSVYNTNGNGTNGMTTPTTPPP------------PT--SGYKAGTLH- 259
            :.|           |::.:.|:.:......:|.|..|||            ||  |.|...:|:
Human   444 LHT-----------NHHYNTYHPDHCRVPALTFPKAPPPNSPPALVSSSFSPTSMSAYSLSSLNM 497

  Fly   260 --LPMT-------AAEMRAKLASKKKYDPKN 281
              ||.:       ...||.:|   ||.|.|:
Human   498 GTLPRSLYSTSPRGTMMRRRL---KKKDFKS 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10939	NP_524712.1	PDZ_signaling	20..101	CDD:238492	22/95 (23%)
GRIP1	XP_016874587.1	PDZ_signaling	128..208	CDD:238492
		PDZ_signaling	227..310	CDD:238492	22/92 (24%)
		PDZ_signaling	325..408	CDD:238492	17/100 (17%)
		PDZ_signaling	545..633	CDD:238492
		PDZ_signaling	646..730	CDD:238492
		PDZ_signaling	746..827	CDD:238492
		PDZ_signaling	1062..1142	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900