DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10939 and PDZD2

DIOPT Version :9

Sequence 1:	NP_524712.1	Gene:	CG10939 / 44155	FlyBaseID:	FBgn0010620	Length:	296	Species:	Drosophila melanogaster
Sequence 2:	XP_005248326.1	Gene:	PDZD2 / 23037	HGNCID:	18486	Length:	2873	Species:	Homo sapiens

Alignment Length:	271	Identity:	62/271 - (22%)
Similarity:	94/271 - (34%)	Gaps:	71/271 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 GYGFNLHSE----KVKPGQFIGKVDAD-SPAEAAGLKEGDRILEVNGVSIGSETHKQVVARIKAI 92
            |.||::...    :.:.|.|:..:..: |.||...|||||.||:|||:.|...|.::.:...|.|
Human   596 GLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQI 660

  Fly    93 ANEVRLLLIDVDGKALEVKPASPP-----AAACNGNGSASQNGYEGTKQEMPGASANIS---SIS 149
            .:.:.:|.:.....:..:.|.|.|     :|:.|.|.|.             ||||..|   |.|
Human   661 RSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSG-------------GASAGGSDEGSSS 712

  Fly   150 MVSTKRSSNASSIQSGSTMNASDLDVVDRGIPAVAAPVAITPPPV--------------QNGSKP 200
            .:..|.......|....|:|....  |..||.|....:..:||.:              .|.|:.
Human   713 SLGRKTPGPKDRIVMEVTLNKEPR--VGLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRG 775

  Fly   201 SSPINNNT--------------LMSTPPPPSATKAGINNNGSV---------------YNTNGNG 236
            ...:..|:              |...||.|.....|.:.|..|               .:...|.
Human   776 DQILEVNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESKEANS 840

  Fly   237 TNGMTTPTTPP 247
            :.|:.||...|
Human   841 SPGLGTPLKSP 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10939	NP_524712.1	PDZ_signaling	20..101	CDD:238492	23/72 (32%)
PDZD2	XP_005248326.1	PDZ_signaling	335..416	CDD:238492
		PDZ_signaling	589..670	CDD:238492	23/73 (32%)
		PDZ_signaling	726..810	CDD:238492	15/85 (18%)
		PDZ_signaling	2623..2694	CDD:238492
		PDZ	2785..2867	CDD:214570
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900