DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10939 and Grip2

DIOPT Version :9

Sequence 1:	NP_524712.1	Gene:	CG10939 / 44155	FlyBaseID:	FBgn0010620	Length:	296	Species:	Drosophila melanogaster
Sequence 2:	NP_612544.2	Gene:	Grip2 / 171571	RGDID:	621668	Length:	1043	Species:	Rattus norvegicus

Alignment Length:	310	Identity:	62/310 - (20%)
Similarity:	108/310 - (34%)	Gaps:	90/310 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PTPPTLPPGVTKTCHIVKRPDFDGYGF--------NLHSEK------VKPGQFIGKVDADSPAEA 60
            |.|...|..::||..:....:.:.:||        :||..:      |:||         .||:.
  Rat   139 PAPENNPRIISKTVDVSLYKEGNSFGFVLRGGAHEDLHKSRPLVLTYVRPG---------GPADR 194

  Fly    61 AG-LKEGDRILEVNGVSIGSETHKQVVARIKAIANEVRLLLIDVDGKALEVKPASPPAAACNGNG 124
            .| ||.|||:|.::|:.:...:|...:|.::..::|. |..::.|        .:.|....|.:|
  Rat   195 EGSLKVGDRLLSIDGIPLHGASHATAIATLQQCSHEA-LFQVEYD--------VATPDTVANASG 250

  Fly   125 SASQNGYEGTKQEMPGASANISSIS-------MVSTKRSSNASSIQSGSTMNASD---------- 172
            ...   .|..|  .||::..||..:       .::..|...||.:.....::|.|
  Rat   251 PLV---VEIAK--TPGSALGISLTTGSHRNKPAITIDRIKPASVVDRSGALHAGDHILAIDGTST 310

  Fly   173 ----LDVVDRGIPAVAAPVAITPPPVQNGSKPSSPINNNTLMST--------------PPPPSAT 219
                |....:.:.:|...|.:...|.....:|..|.....:..:              .|.||..
  Rat   311 EHCSLVEATKLLASVTEKVRLEILPAPQSRRPLKPPEAVRIQRSEQLHHWDPCVPSCHSPRPSHC 375

  Fly   220 KA------GINNNGSVYNTNGNG---------TNGMTTPTTP--PPPTSG 252
            :|      |.:.:.||.:|..:.         .|..|.|..|  |..|:|
  Rat   376 RAPTWAPGGQDQSRSVSSTPFSSPTMNPAFPCANASTLPRGPMSPRTTAG 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10939	NP_524712.1	PDZ_signaling	20..101	CDD:238492	23/95 (24%)
Grip2	NP_612544.2	PDZ_signaling	51..133	CDD:238492
		PDZ_signaling	153..236	CDD:238492	21/92 (23%)
		PDZ_signaling	251..334	CDD:238492	14/87 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	371..450		14/55 (25%)
		PDZ_signaling	456..544	CDD:238492
		PDZ_signaling	557..640	CDD:238492
		PDZ_signaling	657..737	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	745..769
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	786..863
		PDZ_signaling	941..1020	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900