DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10939 and Grid2ip

DIOPT Version :9

Sequence 1:	NP_524712.1	Gene:	CG10939 / 44155	FlyBaseID:	FBgn0010620	Length:	296	Species:	Drosophila melanogaster
Sequence 2:	NP_001152793.1	Gene:	Grid2ip / 170935	MGIID:	2176213	Length:	1203	Species:	Mus musculus

Alignment Length:	424	Identity:	77/424 - (18%)
Similarity:	120/424 - (28%)	Gaps:	203/424 - (47%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 STPTSPKTPTP---------PTLPPGVTKTCHIVKRPDFDGYGFNLHS------EKVKPGQFIGK 51
            :.|..|..|.|         .|.|.|..:|..:.|  ....:||.|..      |.|.||
Mouse   239 AAPRRPDEPPPRKATSLLGGRTGPGGPRRTVRVYK--GNKSFGFTLRGHGPVWIESVLPG----- 296

  Fly    52 VDADSPAEAAGLKEGDRILEVNGVSIGSETHKQVVARIKA------------------------- 91
                ||||.|.||.|||||.:||:.:.:.:|.:||:.::.
Mouse   297 ----SPAENASLKSGDRILFLNGLDMRNCSHDKVVSMLQGSGAMPTLVVEEGPVPFASDSDSLDS 357

  Fly    92 ----------------IANEVRL------------------------------------LLIDV- 103
                            :.:.:|:                                    |::||
Mouse   358 PTRASALTSLQWVADILPSSIRVQGRTFSQQLDHLLTPPERYGVCRALERFFQHRNIDTLIVDVY 422

  Fly   104 ------------------------------------------DGKALEVKPASPPAAACNGNGSA 126
                                                      ...:|:::|.|.|
Mouse   423 PVLDTPAKQVLWQFLYQLLTYEEQELCQEKIACFLGYTAMTEPESSLDLEPESTP---------- 477

  Fly   127 SQNGYEGTKQEMPGASANISSISMVSTKRSSNASSIQSGSTMNASDLDVVDRGIPAVAAPVAITP 191
                 |.|.:..|.:|...||:    .:||..:..:::..:....|...:         |:.:.|
Mouse   478 -----EPTPEPQPRSSLRASSM----CRRSLRSQGLETSLSCGPGDCPEM---------PLPLIP 524

  Fly   192 PPVQNGSKPSSPINNNTLMSTPPPP--SATKAGINNNGSVYNTNGNGTNGMTTPTTPPPP----- 249
            ...|.|...|.|       .||.|.  ||..|.:.   |..|::..|..|..:.:...||
Mouse   525 GERQAGDGTSLP-------ETPNPKMMSAVYAELE---SRLNSSFKGKIGTMSKSRASPPVPSLV 579

  Fly   250 -TSGYKAGTLHLPMTAAEM---RAKLASKKKYDP 279
             |||        |.|.:.:   ..:|.....|||
Mouse   580 GTSG--------PRTLSGVSWPSDRLLPSPCYDP 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10939	NP_524712.1	PDZ_signaling	20..101	CDD:238492	28/163 (17%)
Grid2ip	NP_001152793.1	PDZ_signaling	9..69	CDD:238492
		HN_L-delphilin-R1_like	122..201	CDD:259820
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	215..270		8/30 (27%)
		PDZ_signaling	269..342	CDD:238492	25/83 (30%)
		HN_L-delphilin-R2_like	378..457	CDD:259821	4/78 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	466..541		21/109 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	563..586		7/30 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	611..656
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	710..821
		FH2	812..1180	CDD:280362
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900