DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10939 and FRMPD2

DIOPT Version :9

Sequence 1:	NP_524712.1	Gene:	CG10939 / 44155	FlyBaseID:	FBgn0010620	Length:	296	Species:	Drosophila melanogaster
Sequence 2:	NP_001018081.4	Gene:	FRMPD2 / 143162	HGNCID:	28572	Length:	1309	Species:	Homo sapiens

Alignment Length:	185	Identity:	41/185 - (22%)
Similarity:	73/185 - (39%)	Gaps:	29/185 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 VKRPDFDGYGFNL----HSEKVKPGQFIGKVDADSPAE-AAGLKEGDRILEVNGVSIGSETHKQV 85
            :||....|:||.:    :|.:..||.||..:....||| |..:|.|.:||.:|.:|:...|....
Human   778 LKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMA 842

  Fly    86 VARIKAIANEVRLLLIDVDGKALEVKPASPPAAACNGNGSASQNGYEGTKQEMPGASANISSISM 150
            |..|:...:.:.|::                      :.|....|....:::...|::.:||..:
Human   843 VRMIQNSPDNIELII----------------------SQSKGVGGNNPDEEKNSTANSGVSSTDI 885

  Fly   151 VSTKRSSNASSIQSGSTMNASDLDV--VDRGIPAVAAPVAITPPPVQNGSKPSSP 203
            :|.....:..|.......|..:||:  |...:|.:...::..|......|.|.||
Human   886 LSFGYQGSLLSHTQDQDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSP 940

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10939	NP_524712.1	PDZ_signaling	20..101	CDD:238492	24/79 (30%)
FRMPD2	NP_001018081.4	KIND	15..197	CDD:214801
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	214..249
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	266..302
		B41	346..550	CDD:214604
		FERM_C_PTPH13	546..647	CDD:270008
		PDZ_signaling	773..857	CDD:238492	24/78 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	859..880		3/20 (15%)
		PDZ	947..1034	CDD:214570
		PDZ	1078..1167	CDD:214570
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1204..1228
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810