DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10939 and PARD3B

DIOPT Version :9

Sequence 1:	NP_524712.1	Gene:	CG10939 / 44155	FlyBaseID:	FBgn0010620	Length:	296	Species:	Drosophila melanogaster
Sequence 2:	XP_011508854.1	Gene:	PARD3B / 117583	HGNCID:	14446	Length:	1213	Species:	Homo sapiens

Alignment Length:	393	Identity:	76/393 - (19%)
Similarity:	130/393 - (33%)	Gaps:	132/393 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TPTSPK---TPTPPTLPPGVTKTCHIVKRPDFDGYGFNLHSEKVK-------PGQFIGKVDADSP 57
            :|..|:   .|:.|:|.|             ..|:|.|.:::|:|       .|.....|..||.
Human   360 SPRVPRLGGKPSSPSLSP-------------LMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSS 411

  Fly    58 AEAAG------------------LKEGDRILEVNGVSIGSETHKQVVARIKAI--ANEVRLLLID 102
            ....|                  |:.|||||||||..:...|.:::||.:::.  .....|::..
Human   412 IHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIAR 476

  Fly   103 VDGKAL--EVKPASPPAAA--------------CNGNGSASQN-GYEGTKQEMPGASANISSISM 150
            .:|..|  |:| ..|...|              .|.:|||... ..:|.|....|....|...|:
Human   477 QEGHFLPRELK-GEPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSI 540

  Fly   151 V---------STKRSSNASSIQSGSTMNASDLDVVD------------RG---IPAVAAPVAITP 191
            :         ..:.:....::...|.:..|:.:.::            ||   :..:..|.....
Human   541 IHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPME 605

  Fly   192 PPVQNG--SKP----------SSPINNNTL---MSTPPPPSATKAGINNNGSVYNTNGNGTNGMT 241
            .|.:.|  |||          :|..|:|::   :.|..|....|..:..|           :|..
Human   606 DPAECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPN-----------DGWA 659

  Fly   242 TPTTPPPPTSGYKAG--------------TLHLPMTAAEMRAKLASKKKYDPKNESVDLK--KKF 290
            ....||.||.....|              .::.|......|:...:::.     ||::||  |..
Human   660 ESEVPPSPTPHSALGLGLEDYSHSSGVDSAVYFPDQHINFRSVTPARQP-----ESINLKASKSM 719

  Fly   291 DII 293
            |::
Human   720 DLV 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10939	NP_524712.1	PDZ_signaling	20..101	CDD:238492	24/107 (22%)
PARD3B	XP_011508854.1	DUF3534	<44..151	CDD:288873
		PDZ_signaling	209..296	CDD:238492
		PDZ_signaling	395..475	CDD:238492	19/79 (24%)
		PDZ_signaling	509..597	CDD:238492	13/87 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900