DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10939 and Slc9a3r2

DIOPT Version :9

Sequence 1:	NP_524712.1	Gene:	CG10939 / 44155	FlyBaseID:	FBgn0010620	Length:	296	Species:	Drosophila melanogaster
Sequence 2:	NP_446263.2	Gene:	Slc9a3r2 / 116501	RGDID:	620380	Length:	337	Species:	Rattus norvegicus

Alignment Length:	359	Identity:	97/359 - (27%)
Similarity:	146/359 - (40%)	Gaps:	107/359 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PPTLPPGVTKTCHIVKRPDFDGYGFNLHSEKVKPGQFIGKVDADSPAEAAGLKEGDRILEVNGVS 76
            |.:|.|   :.|.:|:..  .||||:||.||.:.||||.:|:..||||||.|:.|||::|||||:
  Rat     4 PESLRP---RLCRLVRGE--QGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVN 63

  Fly    77 IGSETHKQVVARIKAIANEVRLLLIDVD-------------------GKALEVKPASP-PAAACN 121
            :..|||.|||.||||:..:.:||::|.:                   |......|..| |..||:
  Rat    64 VEGETHHQVVQRIKAVEGQTQLLVVDKETDEELCRRQLTCTEEMAHRGLPPAHNPWEPKPDWACS 128

  Fly   122 GN-GS-ASQNGYEGTKQEM---------------------------------PGASANISSISMV 151
            |: || ..|....|..:|:                                 ||:.|::|.:...
  Rat   129 GSLGSDTGQKDVNGPPRELRPRLCHLRRGPQGYGFNLHSDKSRPGQYIRSVDPGSPASLSGLRAQ 193

  Fly   152 STKRSSNASSIQS----------GSTMNASDLDVVD----------RGIPA---VAAPVAITPPP 193
            ......|..:::.          .:..:.:.|.|||          |.:|.   |..|:   |.|
  Rat   194 DRLIEVNGQNVEGLRHAEVVARIKAQEDEARLLVVDPETDEHFKRLRVVPTEDHVEGPL---PSP 255

  Fly   194 VQNGSKPSSPINNNTLMSTPPPPSATKAGINNNGSVYNTNGNGTNGMTTPTTPPPPTSGYKAGTL 258
            |.||:..:.....:...|....|.:.|.  |.:||.:..:             |...||     |
  Rat   256 VTNGTSLAQLNGGSVCSSRSDLPGSEKD--NEDGSAWKRD-------------PFQESG-----L 300

  Fly   259 HLPMTAAEMRAKLASKKKYDPKNESVDLKKKFDI 292
            ||..||||.:.| |...:.:.:...:|..:|.:|
  Rat   301 HLSPTAAEAKEK-ARATRVNKRAPQMDWNRKREI 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10939	NP_524712.1	PDZ_signaling	20..101	CDD:238492	42/80 (53%)
Slc9a3r2	NP_446263.2	PDZ_signaling	9..88	CDD:238492	43/83 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	127..146		6/18 (33%)
		PDZ_signaling	149..228	CDD:238492	6/78 (8%)
		EBP50_C	232..337	CDD:401087	30/126 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	246..337		28/112 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351290
Domainoid	1	1.000	86	1.000	Domainoid score	I7917
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D377274at33208
OrthoFinder	1	1.000	-	-		FOG0002256
OrthoInspector	1	1.000	-	-		otm44813
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2561
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.710