Protein Alignment Hmgs and hmgcs1

DIOPT Version :10

• Sequence 1: NP_524711.1
• Gene: Hmgs / 44154
• FlyBaseID: FBgn0010611
• Length: 465
• Species: Drosophila melanogaster
• Sequence 2: NP_957379.2
• Gene: hmgcs1 / 394060
• ZFINID: ZDB-GENE-040426-1042
• Length: 526
• Species: Danio rerio
• Alignment Length: 459
• Identity: 294/459 - (64%)
• Similarity: 351/459 - (76%)
• Gaps: 5/459 - (1%)

  Fly     3 SHWPENVGIRAIEILFPSQYVDQTELETFDGASAGKYTIGLGQAKMGFCSDREDVNSLCLTVVSR 67
            |.||::|||.|:|:..|||||||.|||.:||..|||||:|||||:|||||||||:||||||||.|
Zfish    18 SMWPKDVGIIAMEVYVPSQYVDQAELEEYDGVGAGKYTVGLGQARMGFCSDREDINSLCLTVVQR 82

  Fly    68 LLERQHVKHSEIGRLEVGTETIVDKSKSVKSVLMQLFAESGNTDIEGIDTTNACYGGTAALFNAV 132
            |:||..:.:..:||||||||||:|||||.|:||||||.||||||:||:|||||||||||||||||
Zfish    83 LMERNGLSYESVGRLEVGTETIIDKSKSTKTVLMQLFEESGNTDVEGVDTTNACYGGTAALFNAV 147

  Fly   133 NWVESSSWDGRLALAVCADIAVYAKGAARPTGGAGAVAMLVGPNAPLILDRGLRATHMEHAYDFY 197
            |||||||||||.||.|..||||||.|:||||||||||||||||||||..:||||.|||:||||||
Zfish   148 NWVESSSWDGRYALVVAGDIAVYATGSARPTGGAGAVAMLVGPNAPLAFERGLRGTHMQHAYDFY 212

  Fly   198 KPDLSSEYPTVDGKLSIQCYLSALDTCYRLYRKKFDQQ-QKDTSKQPASLSTFDAILFHTPFCKL 261
            |||:.||||.|||||||||||||||.||.:|:.|...: |::.::...||..|..::||:|:|||
Zfish   213 KPDMVSEYPVVDGKLSIQCYLSALDQCYSVYKNKIHARWQREGTEGRCSLEDFGFMVFHSPYCKL 277

  Fly   262 VQKSVGRLSFNDFLL-SSEEERTKQFPDLERFNTATLESTYFDRDVEKAFMTQSANIFASKTKKS 325
            ||||:.||..||||. .|....:..|..||.|....:|.||||||||||||..|:.:|..|||.|
Zfish   278 VQKSLARLMLNDFLCHPSPNMESGPFSGLEAFRDVKIEDTYFDRDVEKAFMKASSELFDDKTKAS 342

  Fly   326 LLLANQVGNMYTPSVYSGLVSLLISGPAQELVGKRIGLFSYGSGLAASMYSISVTQD---AAAFE 387
            ||::||.|||||||||..|.|:|.....|:|.|:|||:||||||.||::|||.||||   .:|.:
Zfish   343 LLISNQNGNMYTPSVYGCLASVLAQHTPQQLAGQRIGVFSYGSGFAATLYSIKVTQDGTPGSALD 407

  Fly   388 KFVSQLDYVQPLLNSREKVAPEQFSALMEVREKNNHAAPYTPTGSISALFPGTYYLKDVDALHRR 452
            |.||.|..:...|:||:||:|..|:..|::||:.:|.|.|.|.||:..|||||:||..||..|||
Zfish   408 KLVSSLCDLPARLDSRQKVSPGVFAETMKLREETHHLANYIPQGSVDELFPGTWYLTRVDEKHRR 472

  Fly   453 TYER 456
            .|.|
Zfish   473 QYAR 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hmgs	NP_524711.1	HMG-CoA-S_euk	5..456	CDD:273826	292/455 (64%)
hmgcs1	NP_957379.2	HMG-CoA-S_euk	20..477	CDD:273826	293/457 (64%)