DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hmgs and HMGCS2

DIOPT Version :9

Sequence 1:	NP_001286488.1	Gene:	Hmgs / 44154	FlyBaseID:	FBgn0010611	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_005509.1	Gene:	HMGCS2 / 3158	HGNCID:	5008	Length:	508	Species:	Homo sapiens

Alignment Length:	458	Identity:	276/458 - (60%)
Similarity:	339/458 - (74%)	Gaps:	4/458 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 WPENVGIRAIEILFPSQYVDQTELETFDGASAGKYTIGLGQAKMGFCSDREDVNSLCLTVVSRLL 69
            ||::|||.|:|:.||:||||||:||.::...|||||:||||.:|||||.:||:||||||||.||:
Human    50 WPKDVGILALEVYFPAQYVDQTDLEKYNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLTVVQRLM 114

  Fly    70 ERQHVKHSEIGRLEVGTETIVDKSKSVKSVLMQLFAESGNTDIEGIDTTNACYGGTAALFNAVNW 134
            ||..:....:||||||||||:||||:||:|||:||.:||||||||||||||||||||:||||.||
Human   115 ERIQLPWDSVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYGGTASLFNAANW 179

  Fly   135 VESSSWDGRLALAVCADIAVYAKGAARPTGGAGAVAMLVGPNAPLILDRGLRATHMEHAYDFYKP 199
            :||||||||.|:.||.|||||..|.|||||||||||||:||.|||.|:||||.||||:.||||||
Human   180 MESSSWDGRYAMVVCGDIAVYPSGNARPTGGAGAVAMLIGPKAPLALERGLRGTHMENVYDFYKP 244

  Fly   200 DLSSEYPTVDGKLSIQCYLSALDTCYRLYRKKFDQQQKDT-SKQPASLSTFDAILFHTPFCKLVQ 263
            :|:||||.|||||||||||.|||.||..||||...|.|.. |.:|.:|.....::|||||||:||
Human   245 NLASEYPIVDGKLSIQCYLRALDRCYTSYRKKIQNQWKQAGSDRPFTLDDLQYMIFHTPFCKMVQ 309

  Fly   264 KSVGRLSFNDFLLSSEEERTKQFPDLERFNTATLESTYFDRDVEKAFMTQSANIFASKTKKSLLL 328
            ||:.||.|||||.:|.:.:|..:..||.|....||.||.::|::||.:..|.::|..|||.||.|
Human   310 KSLARLMFNDFLSASSDTQTSLYKGLEAFGGLKLEDTYTNKDLDKALLKASQDMFDKKTKASLYL 374

  Fly   329 ANQVGNMYTPSVYSGLVSLLISGPAQELVGKRIGLFSYGSGLAASMYSISVTQDAA---AFEKFV 390
            :...|||||.|:|..|.|||....||||.|.|||.||||||||||.:|..|:||||   ..:|.|
Human   375 STHNGNMYTSSLYGCLASLLSHHSAQELAGSRIGAFSYGSGLAASFFSFRVSQDAAPGSPLDKLV 439

  Fly   391 SQLDYVQPLLNSREKVAPEQFSALMEVREKNNHAAPYTPTGSISALFPGTYYLKDVDALHRRTYE 455
            |....:...|.||:.|:||:|:.:|..||:..|...::|.|..::|||||:||:.||..|||.|.
Human   440 SSTSDLPKRLASRKCVSPEEFTEIMNQREQFYHKVNFSPPGDTNSLFPGTWYLERVDEQHRRKYA 504

  Fly   456 RTP 458
            |.|
Human   505 RRP 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hmgs	NP_001286488.1	HMG-CoA-S_euk	5..456	CDD:273826	274/454 (60%)
		cond_enzymes	8..178	CDD:299129	122/169 (72%)
		HMG_CoA_synt_C	179..456	CDD:285711	148/280 (53%)
HMGCS2	NP_005509.1	HMG-CoA-S_euk	50..506	CDD:273826	274/455 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147535
Domainoid	1	1.000	304	1.000	Domainoid score	I1380
eggNOG	1	0.900	-	-		E1_COG3425
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	591	1.000	Inparanoid score	I987
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61358
OrthoDB	1	1.010	-	-		D193643at33208
OrthoFinder	1	1.000	-	-		FOG0003410
OrthoInspector	1	1.000	-	-		otm42174
orthoMCL	1	0.900	-	-		OOG6_101064
Panther	1	1.100	-	-	O	PTHR43323
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2149
SonicParanoid	1	1.000	-	-		X2306
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800