DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hmgs and hcs1

DIOPT Version :9

Sequence 1:	NP_001286488.1	Gene:	Hmgs / 44154	FlyBaseID:	FBgn0010611	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_001342835.1	Gene:	hcs1 / 2543141	PomBaseID:	SPAC4F8.14c	Length:	447	Species:	Schizosaccharomyces pombe

Alignment Length:	459	Identity:	220/459 - (47%)
Similarity:	289/459 - (62%)	Gaps:	24/459 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ENVGIRAIEILFPSQYVDQTELETFDGASAGKYTIGLGQAKMGFCSDREDVNSLCLTVVSRLLER 71
            :::||:.:.:..|:|||:|..||..||.|.||||||||..||.|..||||:.|..||.:|:|::|
pombe     6 KDIGIKGLVLYTPNQYVEQAALEAHDGVSTGKYTIGLGLTKMAFVDDREDIYSFGLTALSQLIKR 70

  Fly    72 QHVKHSEIGRLEVGTETIVDKSKSVKSVLMQLFAESGNTDIEGIDTTNACYGGTAALFNAVNWVE 136
            ..:..|:|||||||||||:||||||||||||||.:  |.::||||..||||||..||||.::|:|
pombe    71 YQIDISKIGRLEVGTETIIDKSKSVKSVLMQLFGD--NHNVEGIDCVNACYGGVNALFNTIDWIE 133

  Fly   137 SSSWDGRLALAVCADIAVYAKGAARPTGGAGAVAMLVGPNAPLILDRGLRATHMEHAYDFYKPDL 201
            ||:||||..:.|..|||:||||.||||||||.||:|||||||::.:.|||.|:|:||||||||||
pombe   134 SSAWDGRDGIVVAGDIALYAKGNARPTGGAGCVALLVGPNAPIVFEPGLRGTYMQHAYDFYKPDL 198

  Fly   202 SSEYPTVDGKLSIQCYLSALDTCYRLYRKKFDQQQKDTSKQPASLSTFDAILFHTPFCKLVQKSV 266
            :||||.|||..|::||:.|||..|..|..:  ...|:...|...|..||..:||.|.||.|||:.
pombe   199 TSEYPYVDGHFSLECYVKALDGAYANYNVR--DVAKNGKSQGLGLDRFDYCIFHAPTCKQVQKAY 261

  Fly   267 GRLSFNDFLLSSEEERTKQFPDL----ERFNTATLESTYFDRDVEKAFMTQSANIFASKTKKSLL 327
            .||.:.|   |:.|...   |:|    |..:|...:.:..|:.:||..|..:...|..:...|:.
pombe   262 ARLLYTD---SAAEPSN---PELEGVRELLSTLDAKKSLTDKALEKGLMAITKERFNKRVSPSVY 320

  Fly   328 LANQVGNMYTPSVYSGLVSLLISGPAQELVGKRIGLFSYGSGLAASMYSISVTQDAAAFEK---F 389
            .....|||||.|::|.|.:||...||.||.|||:|.:|||||||||.:|..|..|.:...|   .
pombe   321 APTNCGNMYTASIFSCLTALLSRVPADELKGKRVGAYSYGSGLAASFFSFVVKGDVSEIAKKTNL 385

  Fly   390 VSQLDYVQPLLNSREKVAPEQFSALMEVREKNNHAAPYTPTGSISALFPGTYYLKDVDALHRRTY 454
            |:.||       :|..:.|.|:...:|:|.:.:....:||.|||..|..|||||..:|.:.||:|
pombe   386 VNDLD-------NRHCLTPTQYEEAIELRHQAHLKKNFTPKGSIERLRSGTYYLTGIDDMFRRSY 443

  Fly   455 ERTP 458
            ...|
pombe   444 SVKP 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hmgs	NP_001286488.1	HMG-CoA-S_euk	5..456	CDD:273826	219/455 (48%)
		cond_enzymes	8..178	CDD:299129	105/169 (62%)
		HMG_CoA_synt_C	179..456	CDD:285711	112/283 (40%)
hcs1	NP_001342835.1	HMG-CoA-S_euk	4..446	CDD:273826	219/456 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	221	1.000	Domainoid score	I547
eggNOG	1	0.900	-	-		E1_COG3425
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1609
Inparanoid	1	1.050	409	1.000	Inparanoid score	I364
OMA	1	1.010	-	-		QHG61358
OrthoFinder	1	1.000	-	-		FOG0003410
OrthoInspector	1	1.000	-	-		oto102048
orthoMCL	1	0.900	-	-		OOG6_101064
Panther	1	1.100	-	-	LDO	PTHR43323
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2149
SonicParanoid	1	1.000	-	-		X2306
TreeFam	1	0.960	-	-
	13	12.950