Protein Alignment Hmgs and hmgs-1

DIOPT Version :9

• Sequence 1: NP_001286488.1
• Gene: Hmgs / 44154
• FlyBaseID: FBgn0010611
• Length: 465
• Species: Drosophila melanogaster
• Sequence 2: NP_504496.1
• Gene: hmgs-1 / 178956
• WormBaseID: WBGene00017769
• Length: 462
• Species: Caenorhabditis elegans
• Alignment Length: 484
• Identity: 192/484 - (39%)
• Similarity: 281/484 - (58%)
• Gaps: 61/484 - (12%)

  Fly     8 NVGIRAIEILFPSQYVDQTELETFDGASAGKYTIGLGQAKMGFCSDREDVNSLCLTVVSRLLERQ 72
            :|||.|||:.||..:|||.:||.|:..|:|||||||||.:||||||.||:.|:.|||..:|:|..
 Worm    13 DVGIGAIELYFPQNFVDQNDLEKFNNVSSGKYTIGLGQQQMGFCSDNEDIVSISLTVTRKLIETY 77

  Fly    73 HVKHSEIGRLEVGTETIVDKSKSVKSVLMQLFAESGNTDIEGIDTTNACYGGTAALFNAVNWVE- 136
            .:....||.|.|||||::|||||||:.||.||  .||:||||:|..|||:||..||.:|::||.
 Worm    78 KISTDSIGCLVVGTETMIDKSKSVKTALMDLF--PGNSDIEGVDIKNACFGGAQALLHAIDWVTV 140

  Fly   137 SSSWDGRLALAVCADIAVYAKGAARPTGGAGAVAMLVGPNAPLILDRGLRATHMEHAYDFYKP-- 199
            :...|.:.|:.|.||||:|.:|.||.||||||:|.|:.|:|.:.:||...|.||::.:||:||
 Worm   141 NHPLDKKNAIVVVADIAIYEEGPARCTGGAGAIAFLICPDASIPIDRQFSACHMKNTWDFFKPIT 205

  Fly   200 DLSSEYPTVDGKLSIQCYLSALDTCYRLYRKKFDQQQKDTSKQPASLSTFDAILFHTPFCKLVQK 264
            .:.||||.|||.||:..||.|:...|..:..|.::......    .|::||.:..|:||.|:|||
 Worm   206 PIPSEYPVVDGSLSLSSYLEAVRMTYTYFISKVNRHTTGID----GLNSFDGVFLHSPFTKMVQK 266

  Fly   265 SVGRLSFNDFLLSSEEERTKQFPDLERFNTATLESTYFDRDVEK------AFMTQ-SANIFASKT 322
            .:..:::.|..|     |.||           |.....|..:::      |.|.: ||.::..||
 Worm   267 GLAVMNYTDSQL-----RHKQ-----------LNGNGVDHKLDENDRAGLAKMIELSAQVWKEKT 315

  Fly   323 KKSLLLANQVGNMYTPSVYSGLVSLLISGPAQELV--GKRIGLFSYGSGLAASMYSISVTQDAAA 385
            ...|:...::|||||||:::.|::.|   .|.:.|  .|.|..|:||||||::::...|.|
 Worm   316 DPYLVFNRRIGNMYTPSLFAQLLAYL---AADDCVTGEKSILFFAYGSGLASAIFPGRVRQ---- 373

  Fly   386 FEKFVSQLDYVQPL-------LNSREKVAPEQFSALMEVRE--KNNHAAPYTPTGSISALFPGTY 441
                .|.||.::.:       |:.|.:..||:|:..::.||  ..:...|.:|  |.::|||.||
 Worm   374 ----TSNLDKIRQVAIRAIKRLDDRIQFTPEEFTETLQKREVFLRSKEIPKSP--SETSLFPNTY 432

  Fly   442 YLKDVDALHRRTY--ERTPT---ISNGVH 465
            :|.::|.|:||:|  ...|.   ..||:|
 Worm   433 FLDNMDKLYRRSYTLHEEPNGVQNGNGIH 461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hmgs	NP_001286488.1	HMG-CoA-S_euk	5..456	CDD:273826	188/470 (40%)
		cond_enzymes	8..178	CDD:299129	94/170 (55%)
		HMG_CoA_synt_C	179..456	CDD:285711	93/298 (31%)
hmgs-1	NP_504496.1	HMG-CoA-S_euk	13..445	CDD:273826	187/466 (40%)
		cond_enzymes	13..181	CDD:299129	94/169 (56%)
		HMG_CoA_synt_C	183..448	CDD:285711	93/297 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159541
Domainoid	1	1.000	188	1.000	Domainoid score	I1960
eggNOG	1	0.900	-	-		E1_COG3425
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	310	1.000	Inparanoid score	I1555
Isobase	1	0.950	-	0	Normalized mean entropy	S675
OMA	1	1.010	-	-		QHG61358
OrthoDB	1	1.010	-	-		D193643at33208
OrthoFinder	1	1.000	-	-		FOG0003410
OrthoInspector	1	1.000	-	-		oto18257
orthoMCL	1	0.900	-	-		OOG6_101064
Panther	1	1.100	-	-	LDO	PTHR43323
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2149
SonicParanoid	1	1.000	-	-		X2306
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.750