DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mAcon1 and ACO1

DIOPT Version :9

Sequence 1:	NP_001097186.2	Gene:	mAcon1 / 44149	FlyBaseID:	FBgn0010100	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_013407.1	Gene:	ACO1 / 851013	SGDID:	S000004295	Length:	778	Species:	Saccharomyces cerevisiae

Alignment Length:	782	Identity:	517/782 - (66%)
Similarity:	610/782 - (78%)	Gaps:	12/782 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LMNAQAQVCR-LGKHVASEATVVRQFHASCYTASKVALSKFDSDVYLPYEKLNKRLEVVRGRLNR 68
            :::|::.:.| :.:.:|:.:.:.|.        |||..:..:...::.|::..:.|::||.||||
Yeast     1 MLSARSAIKRPIVRGLATVSNLTRD--------SKVNQNLLEDHSFINYKQNVETLDIVRKRLNR 57

  Fly    69 PLTLSEKVLYSHLDDPANQDIVRGTSYLRLRPDRVAMQDATAQMALLQFISSGLKKVAVPSTVHC 133
            |.|.:||:||.|||||..|||.||.|||:|||||||.||||||||:|||:|:||.:||.|.||||
Yeast    58 PFTYAEKILYGHLDDPHGQDIQRGVSYLKLRPDRVACQDATAQMAILQFMSAGLPQVAKPVTVHC 122

  Fly   134 DHLIEAQIGGPKDLARAKDLNKEVYDFLASTCAKYGLGFWKPGSGIIHQIILENYAFPGLLMIGT 198
            ||||:||:||.|||.||.||||||||||||..|||.:|||||||||||||:||||||||.|:|||
Yeast   123 DHLIQAQVGGEKDLKRAIDLNKEVYDFLASATAKYNMGFWKPGSGIIHQIVLENYAFPGALIIGT 187

  Fly   199 DSHTPNGGGLGGLCIGVGGADAVDVMADIPWELKCPKVIGVNLTGKISGWTSPKDVILKVADILT 263
            ||||||.||||.|.|||||||||||||..|||||.||::||.||||::|||||||:|||:|.|.|
Yeast   188 DSHTPNAGGLGQLAIGVGGADAVDVMAGRPWELKAPKILGVKLTGKMNGWTSPKDIILKLAGITT 252

  Fly   264 VKGGTGAIIEYHGKGVDSISCTGMATICNMGAEIGATTSLFPFNQRMADYLKSTGRAGIASEAQK 328
            ||||||.|:||.|.|||:.|.|||.||||||||||||||:||||:.|.:||::|||..||..|:.
Yeast   253 VKGGTGKIVEYFGDGVDTFSATGMGTICNMGAEIGATTSVFPFNKSMIEYLEATGRGKIADFAKL 317

  Fly   329 YQAKILSADKNCEYDELIEINLDTLEPHVNGPFTPDLGHPISKLGENSKKNGYPMDIRVGLIGSC 393
            |...:|||||:.||||::||:|:||||::||||||||..|:||:.|.:..|.:|:|:||||||||
Yeast   318 YHKDLLSADKDAEYDEVVEIDLNTLEPYINGPFTPDLATPVSKMKEVAVANNWPLDVRVGLIGSC 382

  Fly   394 TNSSYEDMGRCASIAKDAMSHGLKSKIPFNVTPGSEQIRATIERDGISEVFDKFGGTVLANACGP 458
            ||||||||.|.|||.|||.:||||||..|.||||||||||||||||..|.|.:|||.||||||||
Yeast   383 TNSSYEDMSRSASIVKDAAAHGLKSKTIFTVTPGSEQIRATIERDGQLETFKEFGGIVLANACGP 447

  Fly   459 CIGQWDRKDVKKGDKNTIVTSYNRNFTGRNDANPATHCFVTSPELVTALSIAGRLDFNPLTDELT 523
            |||||||:|:|||||||||:|||||||.|||.||.||.||.|||||||.:|||.|.||||||:|.
Yeast   448 CIGQWDRRDIKKGDKNTIVSSYNRNFTSRNDGNPQTHAFVASPELVTAFAIAGDLRFNPLTDKLK 512

  Fly   524 GADGKKFKLKAPFGDELPAKGFDPGQDTYTAPPPSGENVKVAVDPKSTRLQLLEPFDKWNGQDLT 588
            ..||.:|.||.|.||.||.:|:|.|::||.|||.....|:|.|.|.|.|||||:||..|:|:|..
Yeast   513 DKDGNEFMLKPPHGDGLPQRGYDAGENTYQAPPADRSTVEVKVSPTSDRLQLLKPFKPWDGKDAK 577

  Fly   589 DLTVLIKVKGKCTTDHISAAGPWLKYRGHLDNISNNMFIGATNYENNEMNNIKNQRNGSWGGVPD 653
            |:.:|||..||.||||||.|||||||||||:|||||..|||.|.||.:.|.:||...|.:.||||
Yeast   578 DMPILIKAVGKTTTDHISMAGPWLKYRGHLENISNNYMIGAINAENKKANCVKNVYTGEYKGVPD 642

  Fly   654 VARDYKANGIKWVAVGDENYGEGSSREHAALEPRHLGGRAIIVKSFARIHETNLKKQGLLPLTFA 718
            .||||:..|||||.:||||:||||||||||||||.|||.|||.|||||||||||||||||||.|.
Yeast   643 TARDYRDQGIKWVVIGDENFGEGSSREHAALEPRFLGGFAIITKSFARIHETNLKKQGLLPLNFK 707

  Fly   719 NPADYDKIQPTSKISLLNLKSLAPGKPVDAEI--KNGDKVERIKLNHTLNDLQIGWFKAGSALNR 781
            ||||||||.|..:|.:|.|..|||||||...:  |||...:.: |.||.||.||.|||.|||||:
Yeast   708 NPADYDKINPDDRIDILGLAELAPGKPVTMRVHPKNGKPWDAV-LTHTFNDEQIEWFKYGSALNK 771

  Fly   782 MK 783
            :|
Yeast   772 IK 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAcon1	NP_001097186.2	aconitase_mito	52..782	CDD:273561	509/731 (70%)
		AcnA_Mitochondrial	102..513	CDD:153134	305/410 (74%)
		AcnA_Mitochon_Swivel	595..743	CDD:238810	106/147 (72%)
ACO1	NP_013407.1	aconitase_mito	41..772	CDD:273561	509/731 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343431
Domainoid	1	1.000	678	1.000	Domainoid score	I13
eggNOG	1	0.900	-	-		E1_COG1048
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H856
Inparanoid	1	1.050	1050	1.000	Inparanoid score	I23
Isobase	1	0.950	-	0.8533	Normalized mean entropy	S129
OMA	1	1.010	-	-		QHG61250
OrthoFinder	1	1.000	-	-		FOG0003236
OrthoInspector	1	1.000	-	-		otm46570
orthoMCL	1	0.900	-	-		OOG6_101426
Panther	1	1.100	-	-	LDO	PTHR43160
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3169
TreeFam	1	0.960	-	-
	15	14.710