DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mAcon1 and ACO1

DIOPT Version :9

Sequence 1:	NP_001097186.2	Gene:	mAcon1 / 44149	FlyBaseID:	FBgn0010100	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_195308.1	Gene:	ACO1 / 829737	AraportID:	AT4G35830	Length:	898	Species:	Arabidopsis thaliana

Alignment Length:	859	Identity:	243/859 - (28%)
Similarity:	359/859 - (41%)	Gaps:	188/859 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 EKVLYSHLDDPANQDIVRGTSYLRLRPDRVAMQDATAQMALLQF---------ISSGLKKV--AV 127
            ||:|......|...:|       ..:|.||.:||.|...|::..         :.....|:  .|
plant    65 EKILDWENTSPKQVEI-------PFKPARVLLQDFTGVPAVVDLACMRDAMNNLGGDSNKINPLV 122

  Fly   128 PSTVHCDHLIEAQIGGPKDLARAK-----DLNKEVYDFLASTCAKYGLGFW------KPGSGIIH 181
            |..:..||.::..:...::..:|.     ..|||.:.||     |:|...:      .|||||:|
plant   123 PVDLVIDHSVQVDVARSENAVQANMELEFQRNKERFAFL-----KWGSNAFHNMLVVPPGSGIVH 182

  Fly   182 QIILENYA-----FPGLL----MIGTDSHTPNGGGLGGLCIGVGGADAVDVMADIPWELKCPKVI 237
            |:.||..|     ..|||    ::||||||....|||....||||.:|...|...|..:..|.|:
plant   183 QVNLEYLARVVFNTNGLLYPDSVVGTDSHTTMIDGLGVAGWGVGGIEAEATMLGQPMSMVLPGVV 247

  Fly   238 GVNLTGKISGWTSPKDVILKVADILTVKGGTGAIIEYHGKGVDSISCTGMATICNMGAEIGATTS 302
            |..||||:....:..|::|.|..:|...|..|..:|:||:|:..:|....|||.||..|.|||..
plant   248 GFKLTGKLRDGMTATDLVLTVTQMLRKHGVVGKFVEFHGEGMRELSLADRATIANMSPEYGATMG 312

  Fly   303 LFPFNQRMADYLKSTGRA-GIASEAQKYQAKILSADK----------NCEYDELIEINLDTLEPH 356
            .||.:.....||:.|||: ...|..:.|    |.|:|          ...|...:|:||:.:||.
plant   313 FFPVDHVTLQYLRLTGRSDDTVSMIEAY----LRANKMFVDYSEPESKTVYSSCLELNLEDVEPC 373

  Fly   357 VNGPFTPDLGHPISKLGEN---------------------SKK-----NGYPMDIR-----VGLI 390
            |:||..|....|:.::..:                     ||.     ||....:|     :..|
plant   374 VSGPKRPHDRVPLKEMKADWHSCLDNRVGFKGFAVPKEAQSKAVEFNFNGTTAQLRHGDVVIAAI 438

  Fly   391 GSCTNSSYED-MGRCASIAKDAMSHGLKSK--IPFNVTPGSEQIRATIERDGISEVFDKFGGTVL 452
            .||||:|... |...|.:||.|...||:.|  |..::.|||..:...:.:.|:.:..::.|.:::
plant   439 TSCTNTSNPSVMLGAALVAKKACDLGLEVKPWIKTSLAPGSGVVTKYLAKSGLQKYLNQLGFSIV 503

  Fly   453 ANACGPCIGQWDRKDVKKGDKNTI---------VTSYNRNFTGRNDANPATHC-FVTSPELVTAL 507
            ...|..|||  :..|:.:...:.|         |.|.||||.||  .:|.|.. ::.||.||.|.
plant   504 GYGCTTCIG--NSGDIHEAVASAIVDNDLVASAVLSGNRNFEGR--VHPLTRANYLASPPLVVAY 564

  Fly   508 SIAGRLDFNPLTDEL-TGADGKK--FKLKAPFGDE---------LPAKGFDPGQDTYTAPPPSG- 559
            ::||.:|.:..|..: ||.|||:  |:...|...|         ||    |..:.||.|.....
plant   565 ALAGTVDIDFETQPIGTGKDGKQIFFRDIWPSNKEVAEVVQSSVLP----DMFKATYEAITKGNS 625

  Fly   560 --ENVKVAV------DPKSTRLQLLEPFDKWNGQDLT--------DLTVLIKVKGKCTTDHISAA 608
              ..:.||.      |||||.:.  || ..:.|..::        |...|:......||||||.|
plant   626 MWNQLSVASGTLYEWDPKSTYIH--EP-PYFKGMTMSPPGPHGVKDAYCLLNFGDSITTDHISPA 687

  Fly   609 G------PWLKY---RGHLDNISNNMFIGATNYENNEM-------------NNIKNQRNGSWGGV 651
            |      |..||   || :|....|.:  .:...|:|:             .::|.:.......:
plant   688 GSIHKDSPAAKYLMERG-VDRRDFNSY--GSRRGNDEIMARGTFANIRIVNKHLKGEVGPKTVHI 749

  Fly   652 P--------DVARDYKANGIKWVAVGDENYGEGSSREHAALEPRHLGGRAIIVKSFARIHETNLK 708
            |        |.|..|:..|...:.:....||.||||:.||..|..||.:|:|.|||.|||.:||.
plant   750 PTGEKLSVFDAAMKYRNEGRDTIILAGAEYGSGSSRDWAAKGPMLLGVKAVISKSFERIHRSNLV 814

  Fly   709 KQGLLPLTFANPADYDKIQPTSK----ISL-LNLKSLAPGKPVDAEIKNGDKVERIKLNHTL--- 765
            ..|::||.|....|.:.:..|.:    |.| .|:..:.||:.|.....||.     ....||
plant   815 GMGIIPLCFKAGEDAETLGLTGQELYTIELPNNVSEIKPGQDVTVVTNNGK-----SFTCTLRFD 874

  Fly   766 NDLQIGWFKAGSAL 779
            .::::.:|..|..|
plant   875 TEVELAYFDHGGIL 888

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAcon1	NP_001097186.2	aconitase_mito	52..782	CDD:273561	243/859 (28%)
		AcnA_Mitochondrial	102..513	CDD:153134	146/496 (29%)
		AcnA_Mitochon_Swivel	595..743	CDD:238810	53/182 (29%)
ACO1	NP_195308.1	PLN00070	1..898	CDD:215047	243/859 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1048
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D190960at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820