DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mAcon1 and ACO2

DIOPT Version :9

Sequence 1:	NP_001097186.2	Gene:	mAcon1 / 44149	FlyBaseID:	FBgn0010100	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_567763.2	Gene:	ACO2 / 828805	AraportID:	AT4G26970	Length:	995	Species:	Arabidopsis thaliana

Alignment Length:	802	Identity:	233/802 - (29%)
Similarity:	338/802 - (42%)	Gaps:	161/802 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 LRLRPDRVAMQDATAQMALLQFIS---------SGLKKV--AVPSTVHCDHLIEAQIGGPKDLAR 149
            :..:|.||.:||.|....|:...|         |...|:  .||..:..||.|:......:|.|:
plant   177 IAFKPARVILQDFTGVPVLVDLASMRDAVKNLGSDPSKINPLVPVDLVVDHSIQVDFARSEDAAQ 241

  Fly   150 AKDL------NKEVYDFLASTCAKYGLGFWK------PGSGIIHQIILE----------NYAFPG 192
             |:|      |||.:.||     |:|...::      |||||:||:.||          .:.:|.
plant   242 -KNLELEFKRNKERFTFL-----KWGSTAFQNMLVVPPGSGIVHQVNLEYLGRVVFNSKGFLYPD 300

  Fly   193 LLMIGTDSHTPNGGGLGGLCIGVGGADAVDVMADIPWELKCPKVIGVNLTGKISGWTSPKDVILK 257
             .::||||||....|||....||||.:|...|...|..:..|.|:|..|.||:....:..|::|.
plant   301 -SVVGTDSHTTMIDGLGVAGWGVGGIEAEAAMLGQPMSMVLPGVVGFKLDGKLKEGVTATDLVLT 364

  Fly   258 VADILTVKGGTGAIIEYHGKGVDSISCTGMATICNMGAEIGATTSLFPFNQRMADYLKSTGRAG- 321
            |..||...|..|..:|::|:|:..:|....|||.||..|.|||...||.:....:|||.|||:.
plant   365 VTQILRKHGVVGKFVEFYGEGMSELSLADRATIANMSPEYGATMGFFPVDHVTLEYLKLTGRSDE 429

  Fly   322 IASEAQKY-QAKILSADKN-----CEYDELIEINLDTLEPHVNGPFTPD---------------L 365
            ..|..:.| :|..:..|.|     ..|...::::|..:||.::||..|.               |
plant   430 TVSMIESYLRANNMFVDYNEPQQERAYTSYLQLDLGHVEPCISGPKRPHDRVPLKDMKADWHACL 494

  Fly   366 GHPISKLG-----ENSKK------NGYPMDIR-----VGLIGSCTNSSYED-MGRCASIAKDAMS 413
            .:|:...|     |..::      ||.|.:|:     :..|.||||:|... |...|.:||.|..
plant   495 DNPVGFKGFAVPKEKQEEVVKFSYNGQPAEIKHGSVVIAAITSCTNTSNPSVMIGAALVAKKASD 559

  Fly   414 HGLKSK--IPFNVTPGSEQIRATIERDGISEVFDKFGGTVLANACGPCIGQWDRKD--VKKGDKN 474
            .|||.|  :..::.|||..:...::|.|:.|...|.|..::...|..|||.....|  |....:.
plant   560 LGLKVKPWVKTSLAPGSRVVEKYLDRSGLRESLTKQGFEIVGYGCTTCIGNSGNLDPEVASAIEG 624

  Fly   475 T-----IVTSYNRNFTGRNDANPATHC-FVTSPELVTALSIAGRLDFNPLTDEL-TGADGKKFKL 532
            |     .|.|.||||.||  .:|.|.. ::.||.||.|.::||.:|.:...:.: |.:|||...|
plant   625 TDIIPAAVLSGNRNFEGR--VHPQTRANYLASPPLVVAYALAGTVDIDFEKEPIGTRSDGKSVYL 687

  Fly   533 KA--PFGDE---------LPAKGFDPGQDTYTAPPP------SGENVKVAVDPKSTRLQLLEP-- 578
            :.  |..:|         ||:. |....:|.|...|      :..:...:.||.||.:.  ||
plant   688 RDVWPSNEEVAQVVQYSVLPSM-FKSSYETITEGNPLWNELSAPSSTLYSWDPNSTYIH--EPPY 749

  Fly   579 FDKWNG-----QDLTDLTVLIKVKGKCTTDHISAAG------PWLKY---RGHLDNISNNMFIGA 629
            |.....     :::.|...|:......||||||.||      |..|:   ||.:....|:.....
plant   750 FKNMTANPPGPREVKDAYCLLNFGDSVTTDHISPAGNIQKTSPAAKFLMDRGVISEDFNSYGSRR 814

  Fly   630 TNYENNEMNNIKNQR------NGSWG------------GVPDVARDYKANGIKWVAVGDENYGEG 676
            .|.|........|.|      .|..|            .|.|.|..||......:.:....||.|
plant   815 GNDEVMARGTFANIRIVNKLLKGEVGPNTVHIPTGEKLSVFDAASKYKTAEQDTIILAGAEYGSG 879

  Fly   677 SSREHAALEPRHLGGRAIIVKSFARIHETNLKKQGLLPLTFANPADYDKIQPT----------SK 731
            |||:.||..|..||.:|:|.|||.|||.:||...|::||.|....|.:.:..|          :|
plant   880 SSRDWAAKGPLLLGVKAVIAKSFERIHRSNLAGMGIIPLCFKAGEDAETLGLTGHERYTVHLPTK 944

  Fly   732 ISLLNLKSLAPGKPVDAEIKNG 753
            :|     .:.||:.|.....:|
plant   945 VS-----DIRPGQDVTVTTDSG 961

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAcon1	NP_001097186.2	aconitase_mito	52..782	CDD:273561	233/802 (29%)
		AcnA_Mitochondrial	102..513	CDD:153134	152/492 (31%)
		AcnA_Mitochon_Swivel	595..743	CDD:238810	53/184 (29%)
ACO2	NP_567763.2	PLN00070	70..995	CDD:215047	233/802 (29%)
		AcnA_IRP	183..667	CDD:153136	152/492 (31%)
		AcnA_IRP_Swivel	771..939	CDD:238812	51/167 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1048
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D190960at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820