DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mAcon1 and ACO3

DIOPT Version :9

Sequence 1:	NP_001097186.2	Gene:	mAcon1 / 44149	FlyBaseID:	FBgn0010100	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_178634.2	Gene:	ACO3 / 815120	AraportID:	AT2G05710	Length:	990	Species:	Arabidopsis thaliana

Alignment Length:	878	Identity:	242/878 - (27%)
Similarity:	359/878 - (40%)	Gaps:	196/878 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 LPYEKLNKRLE-VVRGRLNRPLTLS--EKVLYSHLDDPANQDIVRGTSYLRLRPDRVAMQDATAQ 111
            ||| .:...|| .:|...|..:|..  ||::......|...:|       ..:|.||.:||.|..
plant   131 LPY-SIRILLESAIRNCDNFQVTKEDVEKIIDWEKTSPKQVEI-------PFKPARVLLQDFTGV 187

  Fly   112 MALLQF---------ISSGLKKV--AVPSTVHCDHLIEAQIGGPKDLARAK-----DLNKEVYDF 160
            .|::..         :.|...|:  .||..:..||.::..:...::..:|.     ..|||.:.|
plant   188 PAVVDLACMRDAMNKLGSDSNKINPLVPVDLVIDHSVQVDVARSENAVQANMELEFQRNKERFAF 252

  Fly   161 LASTCAKYGLGFWK------PGSGIIHQIILEN-----YAFPGLL----MIGTDSHTPNGGGLGG 210
            |     |:|...::      |||||:||:.||.     :...|||    ::||||||....|||.
plant   253 L-----KWGSTAFQNMLVVPPGSGIVHQVNLEYLGRVVFNTKGLLYPDSVVGTDSHTTMIDGLGV 312

  Fly   211 LCIGVGGADAVDVMADIPWELKCPKVIGVNLTGKISGWTSPKDVILKVADILTVKGGTGAIIEYH 275
            ...||||.:|...|...|..:..|.|:|..|.||:....:..|::|.|..:|...|..|..:|::
plant   313 AGWGVGGIEAEATMLGQPMSMVLPGVVGFKLAGKMRNGVTATDLVLTVTQMLRKHGVVGKFVEFY 377

  Fly   276 GKGVDSISCTGMATICNMGAEIGATTSLFPFNQRMADYLKSTGRAG--IASEAQKYQAKILSADK 338
            |.|:..:|....|||.||..|.|||...||.:.....|||.|||:.  :|......:|..:..|.
plant   378 GNGMSGLSLADRATIANMSPEYGATMGFFPVDHVTLQYLKLTGRSDETVAMIEAYLRANNMFVDY 442

  Fly   339 N-----CEYDELIEINLDTLEPHVNGPFTPD----------------------LGHPISKLGE-- 374
            |     ..|...:|:|||.:||.::||..|.                      .|..|.|..:
plant   443 NEPQQDRVYSSYLELNLDDVEPCISGPKRPHDRVTLKEMKADWHSCLDSKVGFKGFAIPKEAQEK 507

  Fly   375 --NSKKNGYPMDIR-----VGLIGSCTNSSYED-MGRCASIAKDAMSHGLKSK--IPFNVTPGSE 429
              |...:|.|.:::     :..|.||||:|... |.....:||.|...||:.|  |..::.|||.
plant   508 VVNFSFDGQPAELKHGSVVIAAITSCTNTSNPSVMLGAGLVAKKACDLGLQVKPWIKTSLAPGSG 572

  Fly   430 QIRATIERDGISEVFDKFGGTVLANACGPCIGQWDRKDVKKG---DKNTIVT----SYNRNFTGR 487
            .:...:.:.|:.|..::.|..::...|..|||.....:...|   .:|.||.    |.||||.||
plant   573 VVTKYLLKSGLQEYLNEQGFNIVGYGCTTCIGNSGEINESVGAAITENDIVAAAVLSGNRNFEGR 637

  Fly   488 NDANPATHC-FVTSPELVTALSIAGRLDFNPLTDEL-TGADGKKFKLKA--PFGDE--------- 539
              .:|.|.. ::.||.||.|.::||.::.:..|:.: .|.:||...|:.  |..:|
plant   638 --VHPLTRANYLASPPLVVAYALAGTVNIDFETEPIGKGKNGKDVFLRDIWPTTEEIAEVVQSSV 700

  Fly   540 LP----------AKGFDPGQDTYTAPPPSGENVKVAVDPKSTRLQLLEP-------FDKWNGQDL 587
            ||          .|| :|..:..:.|    ||...:.||.||.:.  ||       .|.....::
plant   701 LPDMFRATYESITKG-NPMWNKLSVP----ENTLYSWDPNSTYIH--EPPYFKDMTMDPPGPHNV 758

  Fly   588 TDLTVLIKVKGKCTTDHISAAGPWLKYRGHLDNISNN----MFIGATNYENNEMNNIKNQR---- 644
            .|...|:......||||||.||          ||..:    .|:.....:..:.|:..::|
plant   759 KDAYCLLNFGDSITTDHISPAG----------NIQKDSPAAKFLMERGVDRKDFNSYGSRRGNDE 813

  Fly   645 -----------------NGSWG------------GVPDVARDYKANGIKWVAVGDENYGEGSSRE 680
                             ||..|            .|.|.|..||::|...:.:....||.||||:
plant   814 IMARGTFANIRIVNKLMNGEVGPKTVHIPSGEKLSVFDAAMRYKSSGEDTIILAGAEYGSGSSRD 878

  Fly   681 HAALEPRHLGGRAIIVKSFARIHETNLKKQGLLPLTFANPADYDKIQPTS----KISL-LNLKSL 740
            .||..|...|.:|:|.|||.|||.:||...|::||.|.:..|.|.:..|.    .|.| .::..:
plant   879 WAAKGPMLQGVKAVIAKSFERIHRSNLVGMGIIPLCFKSGEDADTLGLTGHERYTIHLPTDISEI 943

  Fly   741 APGKPVDAEIKNG----------DKVERIKLNH 763
            .||:.|.....||          .:||....||
plant   944 RPGQDVTVTTDNGKSFTCTVRFDTEVELAYFNH 976

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAcon1	NP_001097186.2	aconitase_mito	52..782	CDD:273561	240/876 (27%)
		AcnA_Mitochondrial	102..513	CDD:153134	145/490 (30%)
		AcnA_Mitochon_Swivel	595..743	CDD:238810	51/189 (27%)
ACO3	NP_178634.2	PLN00070	59..990	CDD:215047	242/878 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1048
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D190960at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820