Protein Alignment mAcon1 and Aco2

DIOPT Version :10

• Sequence 1: NP_524708.1
• Gene: mAcon1 / 44149
• FlyBaseID: FBgn0010100
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: NP_077374.2
• Gene: Aco2 / 79250
• RGDID: 621360
• Length: 780
• Species: Rattus norvegicus
• Alignment Length: 781
• Identity: 564/781 - (72%)
• Similarity: 650/781 - (83%)
• Gaps: 13/781 - (1%)

  Fly    12 VCRLGKHVASEATVVRQFH---ASCYTASKVALSKFDSDVYLPYEKLNKRLEVVRGRLNRPLTLS 73
            |.||.|     |..|||:|   |.|..| |||:|.|:...|:.|:.|.|.:.:||.|||||||||
  Rat     8 VTRLQK-----ALGVRQYHVASALCQRA-KVAMSHFEPSEYIRYDLLEKNINIVRKRLNRPLTLS 66

  Fly    74 EKVLYSHLDDPANQDIVRGTSYLRLRPDRVAMQDATAQMALLQFISSGLKKVAVPSTVHCDHLIE 138
            ||::|.||||||||:|.||.:|||||||||||||||||||:||||||||.|||||||:|||||||
  Rat    67 EKIVYGHLDDPANQEIERGKTYLRLRPDRVAMQDATAQMAMLQFISSGLPKVAVPSTIHCDHLIE 131

  Fly   139 AQIGGPKDLARAKDLNKEVYDFLASTCAKYGLGFWKPGSGIIHQIILENYAFPGLLMIGTDSHTP 203
            ||:||.|||.||||:|:|||:|||:..||||:|||:|||||||||||||||:||:|:||||||||
  Rat   132 AQLGGEKDLRRAKDINQEVYNFLATAGAKYGVGFWRPGSGIIHQIILENYAYPGVLLIGTDSHTP 196

  Fly   204 NGGGLGGLCIGVGGADAVDVMADIPWELKCPKVIGVNLTGKISGWTSPKDVILKVADILTVKGGT 268
            |||||||:||||||||||||||.|||||||||||||.|||.:||||||||||||||.||||||||
  Rat   197 NGGGLGGICIGVGGADAVDVMAGIPWELKCPKVIGVKLTGTLSGWTSPKDVILKVAGILTVKGGT 261

  Fly   269 GAIIEYHGKGVDSISCTGMATICNMGAEIGATTSLFPFNQRMADYLKSTGRAGIASEAQKYQAKI 333
            |||:||||.|||||||||||||||||||||||||:||:|.||..||..||||.||:.|::::..:
  Rat   262 GAIVEYHGPGVDSISCTGMATICNMGAEIGATTSVFPYNHRMKKYLSKTGRADIANLAEEFKDHL 326

  Fly   334 LSADKNCEYDELIEINLDTLEPHVNGPFTPDLGHPISKLGENSKKNGYPMDIRVGLIGSCTNSSY 398
            : .|..|:||::|||||:.|:||:||||||||.||::.:|..::|.|:|:|||||||||||||||
  Rat   327 V-PDPGCQYDQVIEINLNELKPHINGPFTPDLAHPVADVGTVAEKEGWPLDIRVGLIGSCTNSSY 390

  Fly   399 EDMGRCASIAKDAMSHGLKSKIPFNVTPGSEQIRATIERDGISEVFDKFGGTVLANACGPCIGQW 463
            |||||.|::||.|::||||.|..|.:|||||||||||||||.:::....||.|||||||||||||
  Rat   391 EDMGRSAAVAKQALAHGLKCKSQFTITPGSEQIRATIERDGYAQILRDVGGIVLANACGPCIGQW 455

  Fly   464 DRKDVKKGDKNTIVTSYNRNFTGRNDANPATHCFVTSPELVTALSIAGRLDFNPLTDELTGADGK 528
            ||||:|||:||||||||||||||||||||.||.||||||:||||:|||.|.|||.||.|||.|||
  Rat   456 DRKDIKKGEKNTIVTSYNRNFTGRNDANPETHAFVTSPEIVTALAIAGTLKFNPETDFLTGKDGK 520

  Fly   529 KFKLKAPFGDELPAKGFDPGQDTYTAPPPSGENVKVAVDPKSTRLQLLEPFDKWNGQDLTDLTVL 593
            ||||:||..||||...||||||||..||......:|.|.|.|.|||||||||||:|:||.||.:|
  Rat   521 KFKLEAPDADELPRSDFDPGQDTYQHPPKDSSGQRVDVSPTSQRLQLLEPFDKWDGKDLEDLQIL 585

  Fly   594 IKVKGKCTTDHISAAGPWLKYRGHLDNISNNMFIGATNYENNEMNNIKNQRNGSWGGVPDVARDY 658
            ||||||||||||||||||||:||||||||||:.|||.|.||.:.|:::|.....:|.|||.||.|
  Rat   586 IKVKGKCTTDHISAAGPWLKFRGHLDNISNNLLIGAINIENGKANSVRNAVTQEFGPVPDTARYY 650

  Fly   659 KANGIKWVAVGDENYGEGSSREHAALEPRHLGGRAIIVKSFARIHETNLKKQGLLPLTFANPADY 723
            |.:||:||.:|||||||||||||||||||||||||||.||||||||||||||||||||||:|:||
  Rat   651 KKHGIRWVVIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPSDY 715

  Fly   724 DKIQPTSKISLLNLKSLAPGKPVDAEIK--NGDKVERIKLNHTLNDLQIGWFKAGSALNRMKELA 786
            :||.|..|:::..||..|||||::..||  ||.: |.|.||||.|:.||.||:|||||||||||.
  Rat   716 NKIHPVDKLTIQGLKDFAPGKPLNCIIKHPNGTQ-ETILLNHTFNETQIEWFRAGSALNRMKELQ 779

  Fly   787 Q 787
            |
  Rat   780 Q 780

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mAcon1	NP_524708.1	aconitase_mito	52..782	CDD:273561	540/731 (74%)
Aco2	NP_077374.2	aconitase_mito	45..775	CDD:273561	540/731 (74%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	524..560		19/35 (54%)