DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mAcon1 and ireb2

DIOPT Version :9

Sequence 1:	NP_001097186.2	Gene:	mAcon1 / 44149	FlyBaseID:	FBgn0010100	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	XP_005163029.1	Gene:	ireb2 / 652982	ZFINID:	ZDB-GENE-051205-1	Length:	974	Species:	Danio rerio

Alignment Length:	771	Identity:	205/771 - (26%)
Similarity:	307/771 - (39%)	Gaps:	155/771 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 IGGPKDLARAKDL----NKEVYDFLASTCAK--YGLGFWKPGSGIIHQIIL----------ENYA 189
            :..|:.:.|.:::    |||...|. ..|:|  ..:....|....:||:.|          |.:.
Zfish   218 VSEPETMVRNQEMELIRNKERLQFF-KWCSKSFNNVNVVPPDISTVHQLNLEYLCKVVQEEEGFI 281

  Fly   190 FPGLLMIGTDSHTPNGGGLGGLCIGVGGADAVDVMADIPWELKCPKVIGVNLTGKISGWTSPKDV 254
            :|. .::||||||....|||.|..||||.::..||...|..|..|:|:|..|.|.|:...:..|:
Zfish   282 YPD-SVVGTDSHTTMINGLGILGWGVGGIESEAVMLGQPVSLTLPQVVGCKLVGTINPLATSIDI 345

  Fly   255 ILKVADILTVKGGTGAIIEYHGKGVDSISCTGMATICNMGAEIGATTSLFPFNQRMADYLKSTGR 319
            :|.:...|...|..|..:|:.|.||..:|.....||.||..|..||.|.||.:.....:.|.|
Zfish   346 VLGITKHLRQAGIGGKFVEFFGPGVPQLSAPDRTTIANMCPEYNATVSFFPVDDITLQHFKHT-- 408

  Fly   320 AGIASEAQ--------KYQAKILSADKNCE---YDELIEINLDTLEPHVNGPFTPDLGHPISKLG 373
              |.||.:        |......|.|...|   |.|:||:||.::.|||:||..|.....|:.:.
Zfish   409 --ICSEEKLLVLEDYLKAVKLFRSYDDQSEEPQYSEVIEMNLSSIVPHVSGPKRPQDRVAITGMK 471

  Fly   374 EN-----SKKNGY--------------PM------------DIRVGLIGSCTNSSYEDMGRCAS- 406
            |:     ::|.|:              |.            .:.:..:.||||:....:...|.
Zfish   472 EDFISCLNEKVGFKGFHISKEKQSTLVPFRHDGAEYNLAHGSVVIAAVISCTNNCNPSVMLAAGL 536

  Fly   407 IAKDAMSHGL--KSKIPFNVTPGSEQIRATIERDGISEVFDKFGGTVLANACGPCIGQW------ 463
            :||.|:..||  |..|..::.|||..:...:...|:.....|.|..|:...|..|:|..
Zfish   537 LAKKAVEAGLTVKPYIRTSLVPGSGTVTHYLNTSGVLPFLKKLGFEVVGYGCATCVGNTAPLPES 601

  Fly   464 --DRKDVKKGDKNTI-VTSYNRNFTGRNDANPATHC----FVTSPELVTALSIAGRLDFNPLTDE 521
              |.  ||:||.... |.|.||:..||     ...|    ::.||.||.|.:|||.:..|..|:.
Zfish   602 VVDA--VKQGDLVACGVLSGNRHLEGR-----LCDCVRANYLASPPLVVAYAIAGTVSINLETEP 659

  Fly   522 L-TGADGKKFKL------------------KAPFGDELPAKGFDPGQDTYTAPPPSGENVKVAVD 567
            | ..||||...|                  .|....||.:: .:.| .::.....|.|:.....|
Zfish   660 LGVNADGKDVFLCDIWPTKEEVNHIEENIVIASMFTELRSR-MEKG-SSFWNNLESAESALFPWD 722

  Fly   568 PKSTRLQLLEPFDKW-----NGQDLTDLTVLIKVKGKCTTDHISAAG------PWLKY------- 614
            ||||.::....|.|.     :.|.:.....|:.:..|.||||||.||      ...||
Zfish   723 PKSTYIRCPSFFSKMSKEVCSPQSIDGAYPLLFLGDKVTTDHISPAGSIARVSAAAKYLQSKRLT 787

  Fly   615 ------------------RGHLDNIS-NNMFIGATNYENNEMNNIKNQRNGSWGGVPDVARDYKA 660
                              ||...:|. .|..||.|..:...:      ..|....|.:.|..|:.
Zfish   788 PREFNSYGARRGNDAVMTRGTFASIKLQNRLIGKTGPKTLHI------PTGQTLDVFEAAERYQR 846

  Fly   661 NGIKWVAVGDENYGEGSSREHAALEPRHLGGRAIIVKSFARIHETNLKKQGLLPLTFANPADYDK 725
            :|:..:.:..:.||.||||:.||..|..||.||:|.:||.:||..:|...|:.||.|....:.|.
Zfish   847 DGVPLIILAGKEYGSGSSRDWAAKGPYLLGVRAVIAESFEKIHRNHLVGMGIAPLQFLPGQNADS 911

  Fly   726 IQPTSK--ISLLNLKSLAPGKPVDAEIKNGDKVERIKLNHTLNDLQIGWFKAGSAL 779
            ::...|  .::...:.|...:.:..:...|.......|..  ||:.:.:|:.|..|
Zfish   912 LELCGKERFTIDIPEELTARQQITVQTSTGKSFMVTALFE--NDMDVEFFRHGGIL 965

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAcon1	NP_001097186.2	aconitase_mito	52..782	CDD:273561	205/771 (27%)
		AcnA_Mitochondrial	102..513	CDD:153134	126/445 (28%)
		AcnA_Mitochon_Swivel	595..743	CDD:238810	49/181 (27%)
ireb2	XP_005163029.1	PTZ00092	10..973	CDD:240263	205/771 (27%)
		Aconitase	89..651	CDD:294203	126/445 (28%)
		AcnA_IRP_Swivel	755..924	CDD:238812	48/174 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1048
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D190960at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820