Protein Alignment mAcon1 and aco1

DIOPT Version :10

• Sequence 1: NP_524708.1
• Gene: mAcon1 / 44149
• FlyBaseID: FBgn0010100
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: NP_001030155.1
• Gene: aco1 / 568448
• ZFINID: ZDB-GENE-031118-76
• Length: 890
• Species: Danio rerio
• Alignment Length: 881
• Identity: 240/881 - (27%)
• Similarity: 365/881 - (41%)
• Gaps: 230/881 - (26%)

  Fly    74 EKVLYSHLDDPANQDIVRG-TSYLRLRPDRVAMQDATAQMALLQF--ISSGLKKV---------A 126
            ||:|        |..:.:. |..:..||.||.:||.|...|::.|  :...:||:         .
Zfish    61 EKIL--------NWKVTQSQTVEVPFRPARVILQDFTGVPAVVDFAAMRDAVKKLQGDPEKINPV 117

  Fly   127 VPSTVHCDHLIEAQIGGPKD-LARAKDL----NKEVYDFLASTCAKYGLGFWK------PGSGII 180
            .|:.:..||.|:.......| |.:.:||    |:|.::||     |:|...::      |||||:
Zfish   118 CPADLVIDHSIQVDFNRKSDSLQKNQDLEFERNRERFEFL-----KWGSKAFRNMRIIPPGSGIV 177

  Fly   181 HQIILE----------NYAFPGLLMIGTDSHTPNGGGLGGLCIGVGGADAVDVMADIPWELKCPK 235
            ||:.||          .:.:|..| :||||||....|||.|..||||.:|..||...|..:..|:
Zfish   178 HQVNLEYLARVVFDQDGFYYPDSL-VGTDSHTTMIDGLGVLGWGVGGIEAEAVMLGQPISMVLPE 241

  Fly   236 VIGVNLTGKISGWTSPKDVILKVADILTVKGGTGAIIEYHGKGVDSISCTGMATICNMGAEIGAT 300
            |||..|.|....:.:..|::|.|...|...|..|..:|:.|.||..:|....|||.||..|.|||
Zfish   242 VIGYRLLGTPDKYITSTDIVLTVTKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANMCPEYGAT 306

  Fly   301 TSLFPFNQRMADYLKSTGRAGIASEAQKYQAKILSA----------DKNCEYDELIEINLDTLEP 355
            .:.||.:|....|||.|||   ..|...|..|.|.|          .::.::.:::|::|.|:||
Zfish   307 AAFFPVDQISIQYLKQTGR---DMEKLSYIEKYLKAVGMFRDYSNTAQDPQFTQVVELDLTTVEP 368

  Fly   356 HVNGPFTPDLGHPISKLGENSK--------KNGYP--------MDIRV----------------- 387
            ..:||..|   |....:.|..|        |.|:.        .|::|
Zfish   369 CCSGPKRP---HDRVSVAEMKKDFETCLVAKQGFKGFQVSPDRCDVQVPFQFNGAEYSLAHGSVV 430

  Fly   388 -GLIGSCTNSSYED-MGRCASIAKDAMSHGL--KSKIPFNVTPGSEQIRATIERDGISEVFDKFG 448
             ..|.||||:|... |.....:|:.|:..||  |..|..:::|||..:...::..|:.:...:.|
Zfish   431 IAAITSCTNTSNPSVMLGAGLLAQKAVQAGLTVKPYIKTSLSPGSGVVTYYLKESGVMDFLSQLG 495

  Fly   449 GTVLANACGPCIGQWDR------KDVKKGDKNTI-VTSYNRNFTGRNDANPATHC-FVTSPELVT 505
            ..|:...|..|||....      :.:.:||.... |.|.||||.||  .:|.|.. ::.||.||.
Zfish   496 FEVVGYGCMTCIGNSGPLPEPVVEAITQGDLVAAGVLSGNRNFEGR--VHPNTRANYLASPPLVI 558

  Fly   506 ALSIAG--RLDF--NPLTDELTGADGKK-------------------------FK---------- 531
            |.:|||  |:||  .||.   ..::||:                         ||
Zfish   559 AYAIAGTVRIDFEKQPLA---VNSEGKEVYLRDIWPTREEIQAVERQFVIPAMFKEVYEKVEKVN 620

  Fly   532 -----LKAPFGDELPAKGFDPGQDTYTAPPPSGENVKVAVDPKSTRLQLLEPFDKWNGQDLTDLT 591
                 |||| .|:|..  :|| ..||...||       ..|..:..||..:|        :||..
Zfish   621 ERWNSLKAP-SDKLYT--WDP-NSTYIKSPP-------FFDGLTRELQTPKP--------ITDAY 666

  Fly   592 VLIKVKGKCTTDHISAAGPWLKYRGHLDNISNN----MFIGATNYENNEMNNIKNQR-------N 645
            ||:.:....||||||.||          ||:.|    .::.:......|.|:..::|       .
Zfish   667 VLLNLGDSVTTDHISPAG----------NIARNSSAARYLTSRGLTAREFNSYGSRRGNDAVMAR 721

  Fly   646 GSWGGVP-------------------------DVARDYKANGIKWVAVGDENYGEGSSREHAALE 685
            |::..:.                         |.|..|:..|...:.:..:.||.||||:.||..
Zfish   722 GTFANIRLFNKFINKQSPTTIYLPTGETLDVFDAAEKYQQAGHPLLILAGKEYGSGSSRDWAAKG 786

  Fly   686 PRHLGGRAIIVKSFARIHETNLKKQGLLPLTFANPADYDK---IQPTSKISLLNLKSLAPGKPVD 747
            |..||.:|::.:|:.|||.:||...|::||.:. |.|..:   :....:.:::....|.|...||
Zfish   787 PFLLGIKAVLAESYERIHRSNLVGMGVIPLEYL-PGDSAESLGLSGRERYTVMIPPLLKPRMTVD 850

  Fly   748 AEIKNGDKVE-RIKLNHTLNDLQIGWFKAGSALNRM 782
            .::..|...: |::.:   .|:::.:|..|..||.|
Zfish   851 IKLDTGKTFQARMRFD---TDVELTYFHHGGILNYM 883

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mAcon1	NP_524708.1	aconitase_mito	52..782	CDD:273561	239/879 (27%)
aco1	NP_001030155.1	PTZ00092	3..886	CDD:240263	240/881 (27%)