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Protein Alignment mAcon1 and ACO2

DIOPT Version :9

Sequence 1:	NP_001097186.2	Gene:	mAcon1 / 44149	FlyBaseID:	FBgn0010100	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_001089.1	Gene:	ACO2 / 50	HGNCID:	118	Length:	780	Species:	Homo sapiens

Alignment Length:	781	Identity:	562/781 - (71%)
Similarity:	646/781 - (82%)	Gaps:	13/781 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VCRLGKHVASEATVVRQFHAS---CYTASKVALSKFDSDVYLPYEKLNKRLEVVRGRLNRPLTLS 73
            |.||.|     |..|||:|.:   |..| |||:|.|:.:.|:.|:.|.|.:.:||.|||||||||
Human     8 VTRLQK-----ALGVRQYHVASVLCQRA-KVAMSHFEPNEYIHYDLLEKNINIVRKRLNRPLTLS 66

  Fly    74 EKVLYSHLDDPANQDIVRGTSYLRLRPDRVAMQDATAQMALLQFISSGLKKVAVPSTVHCDHLIE 138
            ||::|.||||||:|:|.||.||||||||||||||||||||:||||||||.|||||||:|||||||
Human    67 EKIVYGHLDDPASQEIERGKSYLRLRPDRVAMQDATAQMAMLQFISSGLSKVAVPSTIHCDHLIE 131

  Fly   139 AQIGGPKDLARAKDLNKEVYDFLASTCAKYGLGFWKPGSGIIHQIILENYAFPGLLMIGTDSHTP 203
            ||:||.|||.||||:|:|||:|||:..||||:|||||||||||||||||||:||:|:||||||||
Human   132 AQVGGEKDLRRAKDINQEVYNFLATAGAKYGVGFWKPGSGIIHQIILENYAYPGVLLIGTDSHTP 196

  Fly   204 NGGGLGGLCIGVGGADAVDVMADIPWELKCPKVIGVNLTGKISGWTSPKDVILKVADILTVKGGT 268
            |||||||:||||||||||||||.|||||||||||||.|||.:|||:||||||||||.||||||||
Human   197 NGGGLGGICIGVGGADAVDVMAGIPWELKCPKVIGVKLTGSLSGWSSPKDVILKVAGILTVKGGT 261

  Fly   269 GAIIEYHGKGVDSISCTGMATICNMGAEIGATTSLFPFNQRMADYLKSTGRAGIASEAQKYQAKI 333
            |||:||||.|||||||||||||||||||||||||:||:|.||..||..|||..||:.|.:::..:
Human   262 GAIVEYHGPGVDSISCTGMATICNMGAEIGATTSVFPYNHRMKKYLSKTGREDIANLADEFKDHL 326

  Fly   334 LSADKNCEYDELIEINLDTLEPHVNGPFTPDLGHPISKLGENSKKNGYPMDIRVGLIGSCTNSSY 398
            : .|..|.||:||||||..|:||:||||||||.||::::|:.::|.|:|:|||||||||||||||
Human   327 V-PDPGCHYDQLIEINLSELKPHINGPFTPDLAHPVAEVGKVAEKEGWPLDIRVGLIGSCTNSSY 390

  Fly   399 EDMGRCASIAKDAMSHGLKSKIPFNVTPGSEQIRATIERDGISEVFDKFGGTVLANACGPCIGQW 463
            |||||.|::||.|::||||.|..|.:|||||||||||||||.:::....||.|||||||||||||
Human   391 EDMGRSAAVAKQALAHGLKCKSQFTITPGSEQIRATIERDGYAQILRDLGGIVLANACGPCIGQW 455

  Fly   464 DRKDVKKGDKNTIVTSYNRNFTGRNDANPATHCFVTSPELVTALSIAGRLDFNPLTDELTGADGK 528
            ||||:|||:||||||||||||||||||||.||.||||||:||||:|||.|.|||.||.|||.|||
Human   456 DRKDIKKGEKNTIVTSYNRNFTGRNDANPETHAFVTSPEIVTALAIAGTLKFNPETDYLTGTDGK 520

  Fly   529 KFKLKAPFGDELPAKGFDPGQDTYTAPPPSGENVKVAVDPKSTRLQLLEPFDKWNGQDLTDLTVL 593
            ||:|:||..||||...||||||||..||.......|.|.|.|.|||||||||||:|:||.||.:|
Human   521 KFRLEAPDADELPKGEFDPGQDTYQHPPKDSSGQHVDVSPTSQRLQLLEPFDKWDGKDLEDLQIL 585

  Fly   594 IKVKGKCTTDHISAAGPWLKYRGHLDNISNNMFIGATNYENNEMNNIKNQRNGSWGGVPDVARDY 658
            ||||||||||||||||||||:||||||||||:.|||.|.||.:.|:::|.....:|.|||.||.|
Human   586 IKVKGKCTTDHISAAGPWLKFRGHLDNISNNLLIGAINIENGKANSVRNAVTQEFGPVPDTARYY 650

  Fly   659 KANGIKWVAVGDENYGEGSSREHAALEPRHLGGRAIIVKSFARIHETNLKKQGLLPLTFANPADY 723
            |.:||:||.:|||||||||||||||||||||||||||.||||||||||||||||||||||:||||
Human   651 KKHGIRWVVIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPADY 715

  Fly   724 DKIQPTSKISLLNLKSLAPGKPVDAEIK--NGDKVERIKLNHTLNDLQIGWFKAGSALNRMKELA 786
            :||.|..|:::..||...||||:...||  ||.: |.|.||||.|:.||.||:|||||||||||.
Human   716 NKIHPVDKLTIQGLKDFTPGKPLKCIIKHPNGTQ-ETILLNHTFNETQIEWFRAGSALNRMKELQ 779

  Fly   787 Q 787
            |
Human   780 Q 780

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.