DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mAcon1 and aco2

DIOPT Version :9

Sequence 1:	NP_001097186.2	Gene:	mAcon1 / 44149	FlyBaseID:	FBgn0010100	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_001011445.1	Gene:	aco2 / 496933	XenbaseID:	XB-GENE-1000785	Length:	781	Species:	Xenopus tropicalis

Alignment Length:	790	Identity:	570/790 - (72%)
Similarity:	662/790 - (83%)	Gaps:	21/790 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAARLMNAQAQVCRLGKHVASEATVVRQFHAS---CYTASKVALSKFDSDVYLPYEKLNKRLEVV 62
            :|:||..|      || |.|      |::|.|   |..| |||:|.|:::.|:.||:|:|.:.:|
Frog     7 LASRLQQA------LG-HGA------RRYHVSSVLCQRA-KVAMSHFEANEYINYERLDKNINIV 57

  Fly    63 RGRLNRPLTLSEKVLYSHLDDPANQDIVRGTSYLRLRPDRVAMQDATAQMALLQFISSGLKKVAV 127
            |.||:||||||||::|.|:|||..|::|||.:|||||||||||||||||||:||||||||.:|||
Frog    58 RKRLDRPLTLSEKIVYGHIDDPVTQEVVRGKTYLRLRPDRVAMQDATAQMAMLQFISSGLPRVAV 122

  Fly   128 PSTVHCDHLIEAQIGGPKDLARAKDLNKEVYDFLASTCAKYGLGFWKPGSGIIHQIILENYAFPG 192
            |||:|||||||||:||.|||.||||:|:|||:|||:..||||:||||||||||||||||||||||
Frog   123 PSTIHCDHLIEAQLGGEKDLKRAKDINQEVYNFLATAAAKYGVGFWKPGSGIIHQIILENYAFPG 187

  Fly   193 LLMIGTDSHTPNGGGLGGLCIGVGGADAVDVMADIPWELKCPKVIGVNLTGKISGWTSPKDVILK 257
            :|:|||||||||||||||:||||||||||||||.||||||||.||||.|||::||||||||||||
Frog   188 VLLIGTDSHTPNGGGLGGICIGVGGADAVDVMAGIPWELKCPNVIGVKLTGQLSGWTSPKDVILK 252

  Fly   258 VADILTVKGGTGAIIEYHGKGVDSISCTGMATICNMGAEIGATTSLFPFNQRMADYLKSTGRAGI 322
            ||.|||||||||||:||||.|||||||||||||||||||||||||:||:|.||..||..|||:.|
Frog   253 VAGILTVKGGTGAIVEYHGPGVDSISCTGMATICNMGAEIGATTSVFPYNHRMKKYLDKTGRSAI 317

  Fly   323 ASEAQKYQAKILSADKNCEYDELIEINLDTLEPHVNGPFTPDLGHPISKLGENSKKNGYPMDIRV 387
            ||.|.::::.:: .|:.||||:|||||||.|:||:||||||||.:|:|::|..:::.|:|:||||
Frog   318 ASLADEFKSHLV-PDEGCEYDQLIEINLDELKPHINGPFTPDLANPVSEVGAVAEQKGWPLDIRV 381

  Fly   388 GLIGSCTNSSYEDMGRCASIAKDAMSHGLKSKIPFNVTPGSEQIRATIERDGISEVFDKFGGTVL 452
            ||||||||||||||||.|::||.|::||||.|..|.:|||||||||||||||.:.|....||.||
Frog   382 GLIGSCTNSSYEDMGRAAAVAKQALAHGLKCKSQFTITPGSEQIRATIERDGYAAVLRDVGGVVL 446

  Fly   453 ANACGPCIGQWDRKDVKKGDKNTIVTSYNRNFTGRNDANPATHCFVTSPELVTALSIAGRLDFNP 517
            |||||||||||||||:|||:||||||||||||||||||||.||.||||||:||||||||.|.|:|
Frog   447 ANACGPCIGQWDRKDIKKGEKNTIVTSYNRNFTGRNDANPETHAFVTSPEIVTALSIAGTLKFDP 511

  Fly   518 LTDELTGADGKKFKLKAPFGDELPAKGFDPGQDTYTAPPPSGENVKVAVDPKSTRLQLLEPFDKW 582
            ..|.|||||||||||:.|..||||...||||||||..||..|.::||.|.|.|.|||||||||||
Frog   512 EKDFLTGADGKKFKLQPPDADELPKSSFDPGQDTYQHPPKEGSSLKVDVSPTSQRLQLLEPFDKW 576

  Fly   583 NGQDLTDLTVLIKVKGKCTTDHISAAGPWLKYRGHLDNISNNMFIGATNYENNEMNNIKNQRNGS 647
            :|:||.::.:|:|||||||||||||||||||:||||||||||:.|||.|.|||:.|::||..|..
Frog   577 DGKDLENMQILVKVKGKCTTDHISAAGPWLKFRGHLDNISNNLLIGAINLENNKANSVKNCVNQE 641

  Fly   648 WGGVPDVARDYKANGIKWVAVGDENYGEGSSREHAALEPRHLGGRAIIVKSFARIHETNLKKQGL 712
            :|.|||.||.|||:|||||.:|||||||||||||||||||||||||||.||||||||||||||||
Frog   642 YGAVPDTARYYKAHGIKWVVIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGL 706

  Fly   713 LPLTFANPADYDKIQPTSKISLLNLKSLAPGKPVDAEI--KNGDKVERIKLNHTLNDLQIGWFKA 775
            |||||::|||||||.|..||::..||.|||||||...|  :||.: |.|.||||.|:.||.||:|
Frog   707 LPLTFSDPADYDKIHPEDKITIAELKHLAPGKPVKCIITHQNGSQ-ETILLNHTFNETQIEWFQA 770

  Fly   776 GSALNRMKEL 785
            ||||||||||
Frog   771 GSALNRMKEL 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAcon1	NP_001097186.2	aconitase_mito	52..782	CDD:273561	546/731 (75%)
		AcnA_Mitochondrial	102..513	CDD:153134	322/410 (79%)
		AcnA_Mitochon_Swivel	595..743	CDD:238810	116/147 (79%)
aco2	NP_001011445.1	aconitase_mito	47..777	CDD:273561	546/731 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	723	1.000	Domainoid score	I114
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H856
Inparanoid	1	1.050	1161	1.000	Inparanoid score	I204
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101024at33208
OrthoFinder	1	1.000	-	-		FOG0003236
OrthoInspector	1	1.000	-	-		otm47716
Panther	1	1.100	-	-	LDO	PTHR43160
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3169
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160