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Protein Alignment mAcon1 and ACO1

DIOPT Version :9

Sequence 1:	NP_001097186.2	Gene:	mAcon1 / 44149	FlyBaseID:	FBgn0010100	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_001265281.1	Gene:	ACO1 / 48	HGNCID:	117	Length:	889	Species:	Homo sapiens

Alignment Length:	918	Identity:	239/918 - (26%)
Similarity:	375/918 - (40%)	Gaps:	234/918 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 LSKFDSDVY--LPY--------------EKLNKRLEVVRGRLNRPLTLSEKVLYSHLDDPANQDI 89
            |:|.:...|  ||:              |.|.|:.::            |.:|:.::....|.::
Human    24 LNKLEDSRYGRLPFSIRVLLEAAIRNCDEFLVKKQDI------------ENILHWNVTQHKNIEV 76

  Fly    90 VRGTSYLRLRPDRVAMQDATAQMALLQF--ISSGLKKV---------AVPSTVHCDHLIEAQIGG 143
                   ..:|.||.:||.|...|::.|  :...:||:         ..|:.:..||.|:.....
Human    77 -------PFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGDPEKINPVCPADLVIDHSIQVDFNR 134

  Fly   144 PKD-LARAKDL----NKEVYDFLA-STCAKYGLGFWKPGSGIIHQIILE----------NYAFPG 192
            ..| |.:.:||    |:|.::||. .:.|.:.:....||||||||:.||          .|.:|.
Human   135 RADSLQKNQDLEFERNRERFEFLKWGSQAFHNMRIIPPGSGIIHQVNLEYLARVVFDQDGYYYPD 199

  Fly   193 LLMIGTDSHTPNGGGLGGLCIGVGGADAVDVMADIPWELKCPKVIGVNLTGKISGWTSPKDVILK 257
            .| :||||||....|||.|..||||.:|..||...|..:..|:|||..|.||.....:..|::|.
Human   200 SL-VGTDSHTTMIDGLGILGWGVGGIEAEAVMLGQPISMVLPQVIGYRLMGKPHPLVTSTDIVLT 263

  Fly   258 VADILTVKGGTGAIIEYHGKGVDSISCTGMATICNMGAEIGATTSLFPFNQRMADYLKSTGRAGI 322
            :...|...|..|..:|:.|.||..:|....|||.||..|.|||.:.||.::....||..|||
Human   264 ITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANMCPEYGATAAFFPVDEVSITYLVQTGR--- 325

  Fly   323 ASEAQKYQAKILSA----------DKNCEYDELIEINLDTLEPHVNGPFTPDLGHPISK------ 371
            ..|..||..|.|.|          .::.::.:::|::|.|:.|..:||..|.....:|.
Human   326 DEEKLKYIKKYLQAVGMFRDFNDPSQDPDFTQVVELDLKTVVPCCSGPKRPQDKVAVSDMKKDFE 390

  Fly   372 --LGENSKKNGYPM-----------------------DIRVGLIGSCTNSSYED-MGRCASIAKD 410
              ||......|:.:                       .:.:..|.||||:|... |.....:||.
Human   391 SCLGAKQGFKGFQVAPEHHNDHKTFIYDNTEFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKK 455

  Fly   411 AMSHGLKSKIPF---NVTPGSEQIRATIERDGISEVFDKFGGTVLANACGPCIGQWDR------K 466
            |:..|| :.:|:   :::|||..:...::..|:.....:.|..|:...|..|||....      :
Human   456 AVDAGL-NVMPYIKTSLSPGSGVVTYYLQESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEPVVE 519

  Fly   467 DVKKGDKNTI-VTSYNRNFTGRNDANPATHC-FVTSPELVTALSIAG--RLDF--NPLTDELTGA 525
            .:.:||...: |.|.||||.||  .:|.|.. ::.||.||.|.:|||  |:||  .||.   ..|
Human   520 AITQGDLVAVGVLSGNRNFEGR--VHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLG---VNA 579

  Fly   526 DGKKFKLKA--PFGDELPA---KGFDPG-------------------------------QDTYTA 554
            .|::..||.  |..||:.|   :...||                               :.||..
Human   580 KGQQVFLKDIWPTRDEIQAVERQYVIPGMFKEVYQKIETVNESWNALATPSDKLFFWNSKSTYIK 644

  Fly   555 PPPSGENVKVAVDPKSTRLQLLEPFDKWNGQDLTDLTVLIKVKGKCTTDHISAAGPWLKYRGHLD 619
            .||..||:.:.:.|.               :.:.|..||:.:....||||||.||
Human   645 SPPFFENLTLDLQPP---------------KSIVDAYVLLNLGDSVTTDHISPAG---------- 684

  Fly   620 NISNNMFIGATNYENN------EMNNIKNQR-------NGSWGGVP------------------- 652
            ||:.|.  .|..|..|      |.|:..::|       .|::..:.
Human   685 NIARNS--PAARYLTNRGLTPREFNSYGSRRGNDAVMARGTFANIRLLNRFLNKQAPQTIHLPSG 747

  Fly   653 ------DVARDYKANGIKWVAVGDENYGEGSSREHAALEPRHLGGRAIIVKSFARIHETNLKKQG 711
                  |.|..|:..|:..:.:..:.||.||||:.||..|..||.:|::.:|:.|||.:||...|
Human   748 EILDVFDAAERYQQAGLPLIVLAGKEYGAGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMG 812

  Fly   712 LLPLTFANPADYDKIQPT--SKISLLNLKSLAPGKPVDAEIKNGDKVERIKLNHTLNDLQIGWFK 774
            ::||.:....:.|.:..|  .:.:::..::|.|...|..::..|...:.:....|  |:::.:|.
Human   813 VIPLEYLPGENADALGLTGQERYTIIIPENLKPQMKVQVKLDTGKTFQAVMRFDT--DVELTYFL 875

  Fly   775 AGSALNRM 782
            .|..||.|
Human   876 NGGILNYM 883

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.