DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mAcon1 and mAcon2

DIOPT Version :9

Sequence 1:	NP_001097186.2	Gene:	mAcon1 / 44149	FlyBaseID:	FBgn0010100	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_650042.2	Gene:	mAcon2 / 41326	FlyBaseID:	FBgn0037862	Length:	783	Species:	Drosophila melanogaster

Alignment Length:	774	Identity:	614/774 - (79%)
Similarity:	684/774 - (88%)	Gaps:	2/774 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 RLGKHVASEATVVRQFHASCY-TASKVALSKFDSDVYLPYEKLNKRLEVVRGRLNRPLTLSEKVL 77
            |..:::....::||.||.:.: ...|||:|.||:.:.|||:||.:.|:.::|||..|||||||||
  Fly     4 RTHRYICLAGSMVRNFHTARFPRCDKVAMSNFDTGIPLPYKKLRENLDCIKGRLGGPLTLSEKVL 68

  Fly    78 YSHLDDPANQDIVRGTSYLRLRPDRVAMQDATAQMALLQFISSGLKKVAVPSTVHCDHLIEAQIG 142
            |||||.|.:|:|.||.|||||||||||:|||||||.||||||||||||||||||||||||||||.
  Fly    69 YSHLDQPDSQEIERGKSYLRLRPDRVALQDATAQMTLLQFISSGLKKVAVPSTVHCDHLIEAQIS 133

  Fly   143 GPKDLARAKDLNKEVYDFLASTCAKYGLGFWKPGSGIIHQIILENYAFPGLLMIGTDSHTPNGGG 207
            |.|||||||||||||||||:|.||||.||||||||||||||||||||||||||||||||||||||
  Fly   134 GDKDLARAKDLNKEVYDFLSSACAKYNLGFWKPGSGIIHQIILENYAFPGLLMIGTDSHTPNGGG 198

  Fly   208 LGGLCIGVGGADAVDVMADIPWELKCPKVIGVNLTGKISGWTSPKDVILKVADILTVKGGTGAII 272
            ||.||:||||||||||||:||||||||.|||.:|||||||||||||||||||:|||||||||||:
  Fly   199 LGCLCVGVGGADAVDVMANIPWELKCPTVIGCHLTGKISGWTSPKDVILKVAEILTVKGGTGAIV 263

  Fly   273 EYHGKGVDSISCTGMATICNMGAEIGATTSLFPFNQRMADYLKSTGRAGIASEAQKYQAKILSAD 337
            ||||.||:||||||||||.|||||||||||:||||:||..||::|||..||.||.| ...:|..|
  Fly   264 EYHGPGVESISCTGMATITNMGAEIGATTSIFPFNERMVTYLRATGRGAIADEATK-NKDLLVPD 327

  Fly   338 KNCEYDELIEINLDTLEPHVNGPFTPDLGHPISKLGENSKKNGYPMDIRVGLIGSCTNSSYEDMG 402
            :.|:||::||||||||||.|||||||||.|||||||:||:||||||:|:|.||||||||||||||
  Fly   328 EGCKYDKVIEINLDTLEPLVNGPFTPDLAHPISKLGQNSEKNGYPMEIKVSLIGSCTNSSYEDMG 392

  Fly   403 RCASIAKDAMSHGLKSKIPFNVTPGSEQIRATIERDGISEVFDKFGGTVLANACGPCIGQWDRKD 467
            ||||||.||:.|||||.:||||||||||:||||.||||.:|.:||||||||||||||||||||||
  Fly   393 RCASIANDALGHGLKSCVPFNVTPGSEQVRATIARDGIIDVLEKFGGTVLANACGPCIGQWDRKD 457

  Fly   468 VKKGDKNTIVTSYNRNFTGRNDANPATHCFVTSPELVTALSIAGRLDFNPLTDELTGADGKKFKL 532
            ||.|:||||||||||||||||||||||||||||||:.|||:|||||||||:||||||.|||.|||
  Fly   458 VKMGEKNTIVTSYNRNFTGRNDANPATHCFVTSPEMATALAIAGRLDFNPMTDELTGTDGKTFKL 522

  Fly   533 KAPFGDELPAKGFDPGQDTYTAPPPSGENVKVAVDPKSTRLQLLEPFDKWNGQDLTDLTVLIKVK 597
            |.|.|:|||:||||||:|||.|||...:::||.|||||.||||||||:||:|:|..||.||||:|
  Fly   523 KEPHGEELPSKGFDPGEDTYQAPPAKADDIKVNVDPKSDRLQLLEPFEKWDGKDYIDLMVLIKIK 587

  Fly   598 GKCTTDHISAAGPWLKYRGHLDNISNNMFIGATNYENNEMNNIKNQRNGSWGGVPDVARDYKANG 662
            ||||||||||||||||||||||||||||||||||.||||||.:|||:.||:..||.||||||||.
  Fly   588 GKCTTDHISAAGPWLKYRGHLDNISNNMFIGATNAENNEMNKVKNQKTGSFDAVPAVARDYKANK 652

  Fly   663 IKWVAVGDENYGEGSSREHAALEPRHLGGRAIIVKSFARIHETNLKKQGLLPLTFANPADYDKIQ 727
            |||.|||:|||||||||||||||||||||.|||||||||||||||||||:|.||||||.||||:|
  Fly   653 IKWCAVGEENYGEGSSREHAALEPRHLGGVAIIVKSFARIHETNLKKQGMLALTFANPGDYDKVQ 717

  Fly   728 PTSKISLLNLKSLAPGKPVDAEIKNGDKVERIKLNHTLNDLQIGWFKAGSALNRMKELA 786
            |:||||:||||.|||||||||||||....::|:||||||:|||.||:||||||.|||||
  Fly   718 PSSKISILNLKDLAPGKPVDAEIKNNGSSDKIQLNHTLNELQIQWFQAGSALNLMKELA 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAcon1	NP_001097186.2	aconitase_mito	52..782	CDD:273561	596/729 (82%)
		AcnA_Mitochondrial	102..513	CDD:153134	347/410 (85%)
		AcnA_Mitochon_Swivel	595..743	CDD:238810	126/147 (86%)
mAcon2	NP_650042.2	aconitase_mito	43..772	CDD:273561	596/729 (82%)
		AcnA_Mitochondrial	93..503	CDD:153134	347/410 (85%)
		Aconitase_swivel	585..733	CDD:294147	126/147 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447162
Domainoid	1	1.000	705	1.000	Domainoid score	I121
eggNOG	1	0.900	-	-		E1_COG1048
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1156	1.000	Inparanoid score	I198
Isobase	1	0.950	-	0.8533	Normalized mean entropy	S129
OMA	1	1.010	-	-		QHG61250
OrthoDB	1	1.010	-	-		D101024at33208
OrthoFinder	1	1.000	-	-		FOG0003236
OrthoInspector	1	1.000	-	-		otm25940
orthoMCL	1	0.900	-	-		OOG6_101426
Panther	1	1.100	-	-	P	PTHR43160
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3169
	13	12.760