DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mAcon1 and aco2

DIOPT Version :9

Sequence 1:	NP_001097186.2	Gene:	mAcon1 / 44149	FlyBaseID:	FBgn0010100	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_944590.1	Gene:	aco2 / 322670	ZFINID:	ZDB-GENE-030131-1390	Length:	782	Species:	Danio rerio

Alignment Length:	762	Identity:	562/762 - (73%)
Similarity:	642/762 - (84%)	Gaps:	4/762 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 RQFH--ASCYTASKVALSKFDSDVYLPYEKLNKRLEVVRGRLNRPLTLSEKVLYSHLDDPANQDI 89
            |:||  |:....:|||:|:|:...|:.|:||...:::||.|||||||||||::|.||||||.|:|
Zfish    20 RRFHVAAALNAKAKVAMSRFEPSSYINYDKLRSNIDIVRKRLNRPLTLSEKIVYGHLDDPAGQEI 84

  Fly    90 VRGTSYLRLRPDRVAMQDATAQMALLQFISSGLKKVAVPSTVHCDHLIEAQIGGPKDLARAKDLN 154
            .||.:|||||||||||||||||||:||||||||.|||||||:|||||||||.||.:||.:||::|
Zfish    85 ARGRTYLRLRPDRVAMQDATAQMAMLQFISSGLPKVAVPSTIHCDHLIEAQTGGAQDLQKAKEVN 149

  Fly   155 KEVYDFLASTCAKYGLGFWKPGSGIIHQIILENYAFPGLLMIGTDSHTPNGGGLGGLCIGVGGAD 219
            :|||.||||..||||:|||||||||||||||||||:||:::||||||||||||||.:||||||||
Zfish   150 QEVYSFLASAGAKYGVGFWKPGSGIIHQIILENYAYPGVMLIGTDSHTPNGGGLGCICIGVGGAD 214

  Fly   220 AVDVMADIPWELKCPKVIGVNLTGKISGWTSPKDVILKVADILTVKGGTGAIIEYHGKGVDSISC 284
            ||||||.||||||||.||||.|||.:|||:||||||||||.|||||.|||||:||||.|||||||
Zfish   215 AVDVMAGIPWELKCPNVIGVKLTGSLSGWSSPKDVILKVAGILTVKRGTGAIVEYHGPGVDSISC 279

  Fly   285 TGMATICNMGAEIGATTSLFPFNQRMADYLKSTGRAGIASEAQKYQAKILSADKNCEYDELIEIN 349
            ||||||||||||||||||:||||.||..||..|||..||:.|.: ...:|..|..|.||:|||||
Zfish   280 TGMATICNMGAEIGATTSVFPFNHRMKTYLDKTGRGEIATLADE-NKDLLVPDSGCHYDQLIEIN 343

  Fly   350 LDTLEPHVNGPFTPDLGHPISKLGENSKKNGYPMDIRVGLIGSCTNSSYEDMGRCASIAKDAMSH 414
            ||.|:||:||||||||.||:|.:|..::|||:|:|::|||||||||||||||||.||:||.|:..
Zfish   344 LDELKPHINGPFTPDLAHPVSDIGSVAEKNGWPLDVKVGLIGSCTNSSYEDMGRAASLAKQALDK 408

  Fly   415 GLKSKIPFNVTPGSEQIRATIERDGISEVFDKFGGTVLANACGPCIGQWDRKDVKKGDKNTIVTS 479
            |||.|..|.||||||||||||||||.::|....||.|||||||||||||||:|||||:|||||||
Zfish   409 GLKCKAQFTVTPGSEQIRATIERDGYAKVLRDVGGIVLANACGPCIGQWDRRDVKKGEKNTIVTS 473

  Fly   480 YNRNFTGRNDANPATHCFVTSPELVTALSIAGRLDFNPLTDELTGADGKKFKLKAPFGDELPAKG 544
            :|||||.|||||||||.||||||:||||:|||.|.|||.||.||..:|:||||:.|.||||||:.
Zfish   474 FNRNFTARNDANPATHAFVTSPEIVTALAIAGTLKFNPETDYLTAPNGEKFKLEPPTGDELPARD 538

  Fly   545 FDPGQDTYTAPPPSGENVKVAVDPKSTRLQLLEPFDKWNGQDLTDLTVLIKVKGKCTTDHISAAG 609
            ||||||||..||..|..:||.|:|:|.|||||||||||||:||.||.||||||||||||||||||
Zfish   539 FDPGQDTYQHPPADGSALKVDVNPQSNRLQLLEPFDKWNGKDLEDLQVLIKVKGKCTTDHISAAG 603

  Fly   610 PWLKYRGHLDNISNNMFIGATNYENNEMNNIKNQRNGSWGGVPDVARDYKANGIKWVAVGDENYG 674
            ||||:||||||||||:.|||.|.||:.:|.::|...|.:.|||||||.||.|.|.||.|||||||
Zfish   604 PWLKFRGHLDNISNNLLIGAVNIENDGVNKLRNLLTGEYSGVPDVARHYKKNNISWVVVGDENYG 668

  Fly   675 EGSSREHAALEPRHLGGRAIIVKSFARIHETNLKKQGLLPLTFANPADYDKIQPTSKISLLNLKS 739
            |||||||||||||||||||||||||||||||||||||||||||:||||||||:|..|||::.|||
Zfish   669 EGSSREHAALEPRHLGGRAIIVKSFARIHETNLKKQGLLPLTFSNPADYDKIRPDDKISIIGLKS 733

  Fly   740 LAPGKPVDAEIKNGD-KVERIKLNHTLNDLQIGWFKAGSALNRMKEL 785
            .|||||:.|.||:.| ..|.|:||||.|:.||.||:||||||||||:
Zfish   734 FAPGKPLKAVIKHTDGSSETIELNHTFNETQIEWFQAGSALNRMKEM 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAcon1	NP_001097186.2	aconitase_mito	52..782	CDD:273561	548/730 (75%)
		AcnA_Mitochondrial	102..513	CDD:153134	316/410 (77%)
		AcnA_Mitochon_Swivel	595..743	CDD:238810	117/147 (80%)
aco2	NP_944590.1	aconitase_mito	47..777	CDD:273561	548/730 (75%)
		AcnA_Mitochondrial	97..507	CDD:153134	316/410 (77%)
		AcnA_Mitochon_Swivel	589..737	CDD:238810	117/147 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579497
Domainoid	1	1.000	705	1.000	Domainoid score	I121
eggNOG	1	0.900	-	-		E1_COG1048
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H856
Inparanoid	1	1.050	1156	1.000	Inparanoid score	I198
OMA	1	1.010	-	-		QHG61250
OrthoDB	1	1.010	-	-		D101024at33208
OrthoFinder	1	1.000	-	-		FOG0003236
OrthoInspector	1	1.000	-	-		otm25940
orthoMCL	1	0.900	-	-		OOG6_101426
Panther	1	1.100	-	-	LDO	PTHR43160
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3169
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770