DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mAcon1 and leu2

DIOPT Version :9

Sequence 1:	NP_001097186.2	Gene:	mAcon1 / 44149	FlyBaseID:	FBgn0010100	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_594576.1	Gene:	leu2 / 2543296	PomBaseID:	SPAC9E9.03	Length:	758	Species:	Schizosaccharomyces pombe

Alignment Length:	788	Identity:	207/788 - (26%)
Similarity:	318/788 - (40%)	Gaps:	176/788 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 PLTLSEKVLYSHLDDPANQDIVRGTSYLRLRPDRVAMQDATAQMALLQFISSGLKKVAVP----S 129
            |.||.:||..||:.| ..:|   ||..|.:  ||..:.:.|:..|.....::| :||..|    :
pombe     8 PKTLYDKVWDSHVVD-LQED---GTCLLYI--DRHLIHEVTSPQAFEGLRTAG-RKVRHPELALA 65

  Fly   130 TVHCDHLIEAQIGGPKDLARAKDLNKEVYDF------------LASTCAKYGLGFWKPG---SGI 179
            ||  ||.|      |.|  ..||: |::..|            |.:...::||.::...   .||
pombe    66 TV--DHNI------PTD--PRKDM-KDIASFIHQPDSRTQVLALENNIKEFGLTYYGMNDRRQGI 119

  Fly   180 IHQIILE-NYAFPGLLMIGTDSHTPNGGGLGGLCIGVGGADAVDVMADIPWELKCPKVIGVNLTG 243
            :|.|..| .:..||..::..||||...|..|.|..|:|.::...|:|......:..|.:.:.:.|
pombe   120 VHVIGPEQGFTLPGTTLVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTILQRKSKNMRIRVNG 184

  Fly   244 KISGWTSPKDVILKVADILTVKGGTGAIIEYHGKGVDSISCTGMATICNMGAEIGATTSLFPFNQ 308
            |:....:.||:||.:..::...||||::||:.|:.::.:|.....::|||..|.||...:...:.
pombe   185 KLPEGIASKDLILHIIGVIGTAGGTGSVIEFCGEAIEGLSMEARMSMCNMSIEAGARAGMIAPDA 249

  Fly   309 RMADYLKSTGRAGIASEAQKYQA--KILSADKNCEYDELIEINLDTLEPHV------------NG 359
            ...:|:|:...|....:.::..|  |.|.:|:|.:||..:|||...:.|.|            ||
pombe   250 TTFEYVKNRPLAPKGDDWEQAVAYWKTLRSDENAKYDIEVEINAADVLPTVTWGTSPQDVIPING 314

  Fly   360 PFTPDLGH--------PISK------LGENSKKNGYPMDIRVGLIGSCTNSSYEDMGRCASI--- 407
            .. ||..|        .|.:      |..|:....||:| :| .|||||||..||:...|::
pombe   315 NI-PDPAHVKDNVRAASIQRSLEYMGLKPNTSIVSYPID-KV-FIGSCTNSRIEDLRLAAAVVKG 376

  Fly   408 ------AKDAMSHGLKSKIPFNVTPGSEQIRATIERDGISEVFDKFGGTVLANACGPCIGQWDRK 466
                  .||||           :.|||..::...|.:|:.::|.:.|.......|..|:|.  ..
pombe   377 RKVAANVKDAM-----------IVPGSGLVKKMAEAEGLDQIFIEAGFDWREAGCSMCLGM--NP 428

  Fly   467 DVKKGDKNTIVTSYNRNFTGRNDANPATHCFVTSPELVTALSIAGRLDFNPLTDELTGADGKKFK 531
            |..|..:....|| ||||.||..|...||  :.||.:..|.:|.|.|           .:.::|
pombe   429 DQLKPYERCASTS-NRNFEGRQGAKGRTH--LVSPAMAAAAAIKGHL-----------CNVREF- 478

  Fly   532 LKAPFGDE-------LPAKGFDPGQDTYTAPPPSGENVKVAVDPKSTRLQLLEPFDKWNGQDLTD 589
                |||.       :..|.:||..|.      .|: :.::||                  |.||
pombe   479 ----FGDVSNGSPSIITNKNYDPSHDV------EGD-IGLSVD------------------DATD 514

  Fly   590 LT-----VLIKVKGKCTT-----------DHISAAGPWLKYRGHLDNISNNMF---IGATNYENN 635
            ..     :...|.|..::           :.|:|..|....  ..|.|....|   |..|.....
pombe   515 AVTDADGIATNVAGSVSSGSAGIPKFTVVEGIAAPLPMANV--DTDKIIPKQFLKTIKRTGLGQF 577

  Fly   636 EMNNIKNQRNGSWGGVPDVARDYKANGIKWVAVGDENYGEGSSREHAALEPRHLGGRAIIVKSFA 700
            ....|:...:|.  .:||...:.:......|.|..:|:|.|||||||.......|.|.||..|||
pombe   578 AFYEIRYDADGK--EIPDFVLNREPYRHATVLVAHDNFGCGSSREHAPWALNDFGIRVIIAPSFA 640

  Fly   701 RIHETNLKKQGLLPLTFANPADYDKIQPTSKISLLNLKSLAPGKPVDAEIKNGDK-----VERIK 760
            .|...|..|.|:||:    |...:::....|.:...:|...  ..|:..|..|||     ||..:
pombe   641 DIFFNNCFKNGMLPI----PTPIEQVNDMMKAAENQVKFSV--DLVNQTITYGDKQVKFDVEPFR 699

  Fly   761 LNHTLNDL 768
            .:..:|.|
pombe   700 KHCLVNGL 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAcon1	NP_001097186.2	aconitase_mito	52..782	CDD:273561	207/788 (26%)
		AcnA_Mitochondrial	102..513	CDD:153134	129/467 (28%)
		AcnA_Mitochon_Swivel	595..743	CDD:238810	41/161 (25%)
leu2	NP_594576.1	PRK05478	7..478	CDD:235490	143/517 (28%)
		aconitase_mito	8..681	CDD:273561	198/760 (26%)
		leuD	539..734	CDD:179314	48/179 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.870