Protein Alignment mAcon1 and lys2

DIOPT Version :9

• Sequence 1: NP_001097186.2
• Gene: mAcon1 / 44149
• FlyBaseID: FBgn0010100
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: NP_593437.1
• Gene: lys2 / 2542867
• PomBaseID: SPAC343.16
• Length: 721
• Species: Schizosaccharomyces pombe
• Alignment Length: 688
• Identity: 177/688 - (25%)
• Similarity: 284/688 - (41%)
• Gaps: 127/688 - (18%)

  Fly    69 PLTLSEKVLYSHLDDPANQDIVRGTSYLRLRPDRVAMQDATAQMALLQFISSGLKKVAVPSTVHC 133
            |.|::||::.....:......||...|:.::|......|.:..:| |:|:..|.|||.....:.|
pombe    60 PQTITEKIVQKFAQNIPENKYVRSGDYVTIKPKHCMSHDNSWPVA-LKFMGIGAKKVFDNRQIVC 123

  Fly   134 --DHLIEAQIGGPKDLARAKDLNKEVYDFLASTCAKYGLGFWKPGSGIIHQIILE-NYAFPGLLM 195
              ||          |:....:.|...|..:.|.....|:.|:..|.||.|||::| .||.||.:.
pombe   124 TLDH----------DVQNKSEANLRKYKNIESFAKGQGIDFYPAGRGIGHQIMVEQGYAMPGSMA 178

  Fly   196 IGTDSHTPNGGGLGGLCIG--VGGADAVDVMA--DIPWELKCPKVIGVNLTGKISGWTSPKDVIL 256
            :.:|||:...||:|  |:|  :...||..:.|  ...|::  |.:..|||.|::....|.||:|:
pombe   179 VASDSHSNTYGGVG--CLGTPIVRTDAAAIWATGQTWWQI--PPIARVNLVGQLPKGLSGKDIIV 239

  Fly   257 KVADILTVKGGTGAIIEYHGKGVDSISCTGMATICNMGAEIGATTSLFPFNQRM----ADYLKST 317
            .:.............||::|:|::|:|.....||.||..|.||.:.|||.::::    .|.||..
pombe   240 SLCGAFNHDEVLNHAIEFYGEGLNSLSIESRLTIANMTTEWGALSGLFPTDEKLLAWYEDRLKFL 304

  Fly   318 G--RAGIASEA-QKYQAKILSADKNCEYDELIEINLDTLEPHVNGPFTPDLGHPISKLGENSKKN 379
            |  ...:..|. ...:|..:.||:...|.:.:.::|.||.|.|:||.:..:.:..:.|   .||:
pombe   305 GPNHPRVNRETLDAIKASPILADEGAFYAKHLILDLSTLSPAVSGPNSVKVYNSAATL---EKKD 366

  Fly   380 GYPMDIRVGLIGSCTNSSYEDMGRCASIAKDAMSHGLK--SKIPFNVTPGSEQIRATIERDGISE 442
               :.|:...:.||||....|:...|...|     |.|  ..:.|.|...|.::.|..:::|..:
pombe   367 ---ILIKKAYLVSCTNGRLSDIHDAAETVK-----GKKVADGVEFYVGAASSEVEAAAQKNGDWQ 423

  Fly   443 VFDKFGGTVLANACGPCIGQWD--RKDVKKGDKNTIVTSYNRNFTGRNDANPATHCFVTSPELVT 505
            .....|...|...||||||...  .||.:.|     :::.||||.||..:..|. .::.||.:|.
pombe   424 TLIDSGARTLPAGCGPCIGLGTGLLKDGEVG-----ISATNRNFKGRMGSREAL-AYLASPAVVA 482

  Fly   506 ALSIAGRLDFNPLTDELTGADGKKFKLKAPFGDE-----LPAKGFDPGQDTYTAPPPSGENVKVA 565
            |.:|||                   |:.||.|.:     :.|.......:..||...|.|    |
pombe   483 ASAIAG-------------------KIVAPEGFKNAVSLVSAVDITDKVNKQTASKSSTE----A 524

  Fly   566 VDPKSTRLQLLEPFDKWNGQDLTDLTVLIKVKGK---CTTDHISAAGPWLKYRGHLDNISNNMFI 627
            ||.::.   :::.|..             .|.|:   |..|:::..|.:.....:.|:|:
pombe   525 VDSETA---IIDGFPS-------------IVAGEIVFCDADNLNTDGIYPGRYTYRDDIT----- 568

  Fly   628 GATNYENNEMNNIKNQRNGSWGGVPDVARDYKANGIKWVAVGDENYGEGSSREHAALEPRHLGGR 692
                  ..||..:..:...|..|......|...:|.        |:|.|||||.||......|..
pombe   569 ------KEEMAKVCMENYDSEFGKKTKKDDILVSGF--------NFGTGSSREQAATAILSRGIP 619

  Fly   693 AIIVKSFARIHETNLKKQGLLPL-----------TFAN 719
            .::..||:.|.:.|.....||.:           .|||
pombe   620 LVVGGSFSDIFKRNSINNALLAIQLPDLVQKLRTAFAN 657

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mAcon1	NP_001097186.2	aconitase_mito	52..782	CDD:273561	177/688 (26%)
		AcnA_Mitochondrial	102..513	CDD:153134	124/428 (29%)
		AcnA_Mitochon_Swivel	595..743	CDD:238810	32/139 (23%)
lys2	NP_593437.1	h_aconitase	60..717	CDD:129245	177/688 (26%)
		Homoaconitase	93..490	CDD:153132	124/447 (28%)
		Homoaconitase_Swivel	546..674	CDD:238837	30/131 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1048
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.770