DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mAcon1 and SPBP4H10.15

DIOPT Version :9

Sequence 1:	NP_001097186.2	Gene:	mAcon1 / 44149	FlyBaseID:	FBgn0010100	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_596189.3	Gene:	SPBP4H10.15 / 2541348	PomBaseID:	SPBP4H10.15	Length:	918	Species:	Schizosaccharomyces pombe

Alignment Length:	801	Identity:	430/801 - (53%)
Similarity:	549/801 - (68%)	Gaps:	35/801 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 AQAQVCRLGKHVA----SEATVVRQFHASCYTASKVALSKFDSDVYLPYEKLNKRLEVVRGRL-N 67
            |:.::|..|...|    ..:.|..:|.:   |||:.      |.|..|||||..:|:.||..| .
pombe     5 ARMKLCLSGSSQAIPSKGISLVAARFQS---TASRA------SYVTPPYEKLMGKLQQVRKFLPG 60

  Fly    68 RPLTLSEKVLYSHLDDP------ANQDIVRGTSYLRLRPDRVAMQDATAQMALLQFISSGLKKVA 126
            :.|||:||||||||.:|      .:...:||:.||:|.|||||||||:||||||||::.||:|..
pombe    61 QKLTLAEKVLYSHLVNPEESFSGVSPSDIRGSLYLKLNPDRVAMQDASAQMALLQFMTCGLEKTM 125

  Fly   127 VPSTVHCDHLIEAQIGGPKDLARAKDLNKEVYDFLASTCAKYGLGFWKPGSGIIHQIILENYAFP 191
            :|:::||||||....|...|:..:...|||::|||.|...|||:.||.|||||||||:|||||.|
pombe   126 IPASIHCDHLIVGHRGANSDIPDSIANNKEIFDFLQSAAKKYGIQFWGPGSGIIHQIVLENYAAP 190

  Fly   192 GLLMIGTDSHTPNGGGLGGLCIGVGGADAVDVMADIPWELKCPKVIGVNLTGKISGWTSPKDVIL 256
            |.:|:||||||||.||||.:.||||||||||.|.:.|||||.||:|||||||.:||||:|||:||
pombe   191 GGMMLGTDSHTPNAGGLGMIAIGVGGADAVDAMTNTPWELKAPKIIGVNLTGAMSGWTTPKDLIL 255

  Fly   257 KVADILTVKGGTGAIIEYHGKGVDSISCTGMATICNMGAEIGATTSLFPFNQRMADYLKSTGRAG 321
            .:|..|||:||||.||||.|.||.|:|||||||:||||||:|||||:||:...|..||.:|.||.
pombe   256 HLAGKLTVRGGTGHIIEYFGPGVASLSCTGMATVCNMGAEVGATTSIFPYTDSMRRYLIATHRAE 320

  Fly   322 IASEAQKYQAK--ILSADKNCEYDELIEINLDTLEPHVNGPFTPDLGHPISKLGENSKKNGYPMD 384
            :|..|.:..::  .|:||...:||::|:|||..|.|.:||||||||..|:||.||..:||.:|..
pombe   321 VADAASEVHSEYNYLAADTGAKYDQIIDINLSELTPSLNGPFTPDLSTPVSKFGEAIEKNKWPKK 385

  Fly   385 IRVGLIGSCTNSSYEDMGRCASIAKDAMSHGLKSKIPFNVTPGSEQIRATIERDGISEVFDKFGG 449
            :..|||||||||||:||.....:.:.|:|.|||.|:||.|||||||||||||||||:|..::.|.
pombe   386 LSAGLIGSCTNSSYQDMTCVVDVVEQAISAGLKPKVPFLVTPGSEQIRATIERDGITERLEEAGA 450

  Fly   450 TVLANACGPCIGQWDR-KDVKKGDKNTIVTSYNRNFTGRNDANPATHCFVTSPELVTALSIAGRL 513
            ||||||||||||.|.| .|:..|:.|.|:||:||||..|||.||:|..|:|||.:|.|...:..|
pombe   451 TVLANACGPCIGMWKRTDDIASGEPNAILTSFNRNFRSRNDGNPSTMNFLTSPVIVAAKIFSSDL 515

  Fly   514 DFNPLTDELTGADGKKFKLKAPFGDELPAKGFDPGQDTYTAPPPSGENV---KVAVDPKSTRLQL 575
            .|:|..|.|...|||.||.:.|.|.|||:.||..|..:| .|.|:.:.|   :|.:||||.||:.
pombe   516 AFDPTHDTLQTPDGKAFKFRPPQGVELPSAGFIAGDSSY-IPEPNPQPVPETEVTIDPKSDRLEA 579

  Fly   576 LEPFDKWNGQDLTDLTVLIKVKGKCTTDHISAAGPWLKYRGHLDNISNNMFIGATNYENNEMNNI 640
            ||||:.:.|.::.:|.|.:|||||||||||||||.||||:|||.||.||..|||.|....|:|..
pombe   580 LEPFEPYQGGEMENLKVAVKVKGKCTTDHISAAGKWLKYKGHLSNICNNTLIGAMNAATGEVNRA 644

  Fly   641 KNQRNGSWGGVPDVARDYKANGIKWVAVGDENYGEGSSREHAALEPRHLGGRAIIVKSFARIHET 705
            .:  ||....:|::...:|.:|..|:.|.:.||||||:||||||:||.:.||.|:.|||||||||
pombe   645 YD--NGKGMTIPELMWKWKKDGQPWLVVAEHNYGEGSAREHAALQPRAMNGRIILTKSFARIHET 707

  Fly   706 NLKKQGLLPLTFANPADYDKIQPTSKISLLNLKSLAPG---KPVDAEI--KNGDKVERIKLNHTL 765
            ||||||:|||||.|.|||:||....|:|...::.|..|   :|:...:  |:|..|| |...||:
pombe   708 NLKKQGVLPLTFVNEADYEKIDAEDKVSTRGIEQLLEGVLDQPITLVVTKKDGSVVE-IPCKHTM 771

  Fly   766 NDLQIGWFKAGSALNRMKELA 786
            :..||.:||||||||.::|.|
pombe   772 SKDQIEFFKAGSALNLIREKA 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAcon1	NP_001097186.2	aconitase_mito	52..782	CDD:273561	416/747 (56%)
		AcnA_Mitochondrial	102..513	CDD:153134	249/413 (60%)
		AcnA_Mitochon_Swivel	595..743	CDD:238810	85/147 (58%)
SPBP4H10.15	NP_596189.3	aconitase_mito	44..788	CDD:273561	416/747 (56%)
		Aconitase	101..515	CDD:294203	249/413 (60%)
		Aconitase_swivel	599..745	CDD:294147	85/147 (58%)
		Ribosomal_L21p	820..908	CDD:279202
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1048
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003236
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101426
Panther	1	1.100	-	-	O	PTHR43160
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.770