DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PpD5 and PPP3CB

DIOPT Version :9

Sequence 1:NP_524707.1 Gene:PpD5 / 44148 FlyBaseID:FBgn0005778 Length:346 Species:Drosophila melanogaster
Sequence 2:NP_001135825.1 Gene:PPP3CB / 5532 HGNCID:9315 Length:525 Species:Homo sapiens


Alignment Length:331 Identity:122/331 - (36%)
Similarity:186/331 - (56%) Gaps:33/331 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 TGKESSKE--EKNRMSQLDVIIGQLKTMAVGNRRAGNLSEATITYICQASRELFLSQPMLLELSA 72
            |.:.:|:|  :.:.:.::||:...|.       :.|.:.|.....|......:...:..::|:.|
Human    35 THRLTSEEVFDLDGIPRVDVLKNHLV-------KEGRVDEEIALRIINEGAAILRREKTMIEVEA 92

  Fly    73 PVKICGDLHGQFKDLLRIFQQCGVPPLSNYLFLGDYVDRGHCSIETLSLLLTYKLRYPETFFLLR 137
            |:.:|||:||||.||:::|:..|.|..:.|||||||||||:.|||.:..|...|:.||.|.||||
Human    93 PITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLR 157

  Fly   138 GNHESADLNRVYGFFDECKRRYSIKLWRSFVDCYDCMPVAAIIADRIFCVHGGLSPDLNNLDDIR 202
            ||||...|...:.|..|||.:||.:::.:.::.:|.:|:||::..:..||||||||:::.|||||
Human   158 GNHECRHLTEYFTFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIR 222

  Fly   203 RLNRPTDVPSDGLLCDLLWSDPDETTGTWASND-------RGVSFTFGANIVEGFLMQHKFNLIV 260
            ||:|..:.|:.|.:||||||||.|..|...|.:       ||.|:.:....|..||..:....|:
Human   223 RLDRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYNYPAVCEFLQNNNLLSII 287

  Fly   261 RAHQVVEDGYEFFADRQ------LVTIFSAPNYCDIFDNCGAVLVVDAKLV------CHFVIIRP 313
            |||:..:.||..:...|      |:||||||||.|:::|..|||..:..::      |     .|
Human   288 RAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNC-----SP 347

  Fly   314 RPFSRP 319
            .|:..|
Human   348 HPYWLP 353

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpD5NP_524707.1 PTZ00480 19..339 CDD:185658 119/320 (37%)
MPP_superfamily 25..313 CDD:301300 116/306 (38%)
PPP3CBNP_001135825.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..25
MPP_PP2B 50..354 CDD:277361 119/316 (38%)
Catalytic. /evidence=ECO:0000305 65..356 115/294 (39%)
SAPNY motif. /evidence=ECO:0000250|UniProtKB:Q08209 316..320 3/3 (100%)
Calcineurin B binding. /evidence=ECO:0000269|PubMed:26794871 357..379
Calmodulin-binding. /evidence=ECO:0000269|PubMed:26794871 402..416
Autoinhibitory segment. /evidence=ECO:0000269|PubMed:26794871 417..424
Autoinhibitory domain. /evidence=ECO:0000269|PubMed:26794871 475..497
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0639
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53795
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

Return to query results.
Submit another query.