DRSC/TRiP Functional Genomics Resources

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Protein Alignment PpD5 and PPP3CA

DIOPT Version :10

Sequence 1:NP_524707.1 Gene:PpD5 / 44148 FlyBaseID:FBgn0005778 Length:346 Species:Drosophila melanogaster
Sequence 2:NP_000935.1 Gene:PPP3CA / 5530 HGNCID:9314 Length:521 Species:Homo sapiens


Alignment Length:327 Identity:123/327 - (37%)
Similarity:186/327 - (56%) Gaps:33/327 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 SSKE--EKNRMSQLDVIIGQLKTMAVGNRRAGNLSEATITYICQASRELFLSQPMLLELSAPVKI 76
            ::||  :.:...::|::...|       .:.|.|.|:....|......:...:..||::.|||.:
Human    30 TAKEVFDNDGKPRVDILKAHL-------MKEGRLEESVALRIITEGASILRQEKNLLDIDAPVTV 87

  Fly    77 CGDLHGQFKDLLRIFQQCGVPPLSNYLFLGDYVDRGHCSIETLSLLLTYKLRYPETFFLLRGNHE 141
            |||:||||.||:::|:..|.|..:.|||||||||||:.|||.:..|...|:.||:|.||||||||
Human    88 CGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHE 152

  Fly   142 SADLNRVYGFFDECKRRYSIKLWRSFVDCYDCMPVAAIIADRIFCVHGGLSPDLNNLDDIRRLNR 206
            ...|...:.|..|||.:||.:::.:.:|.:||:|:||::..:..||||||||::|.|||||:|:|
Human   153 CRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDR 217

  Fly   207 PTDVPSDGLLCDLLWSDPDETTGTWASND-------RGVSFTFGANIVEGFLMQHKFNLIVRAHQ 264
            ..:.|:.|.:||:|||||.|..|...:.:       ||.|:.:....|..||..:....|:|||:
Human   218 FKEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHE 282

  Fly   265 VVEDGYEFFADRQ------LVTIFSAPNYCDIFDNCGAVLVVDAKLV------CHFVIIRPRPFS 317
            ..:.||..:...|      |:||||||||.|:::|..|||..:..::      |     .|.|:.
Human   283 AQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNC-----SPHPYW 342

  Fly   318 RP 319
            .|
Human   343 LP 344

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpD5NP_524707.1 MPP_superfamily 25..313 CDD:472684 118/306 (39%)
PPP3CANP_000935.1 MPP_PP2B 41..345 CDD:277361 121/316 (38%)
Catalytic. /evidence=ECO:0000305 56..340 116/288 (40%)
SAPNY motif. /evidence=ECO:0000305|PubMed:26248042 307..311 3/3 (100%)
Interaction with PxIxIF motif in substrate. /evidence=ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:17502104, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26248042 327..336 0/8 (0%)
Calcineurin B binding. /evidence=ECO:0000269|PubMed:12218175, ECO:0000269|PubMed:12357034, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:8524402 341..369 1/4 (25%)
Calmodulin-binding. /evidence=ECO:0000269|PubMed:18384083, ECO:0000269|PubMed:19404396, ECO:0000269|PubMed:25144868, ECO:0000269|Ref.34 392..406
Autoinhibitory segment. /evidence=ECO:0000250|UniProtKB:P16298 407..414
Autoinhibitory domain. /evidence=ECO:0000269|PubMed:8524402 465..487
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 475..521
Blue background indicates that the domain is not in the aligned region.

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