DRSC/TRiP Functional Genomics Resources

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Protein Alignment PpD5 and PPEF2

DIOPT Version :9

Sequence 1:NP_524707.1 Gene:PpD5 / 44148 FlyBaseID:FBgn0005778 Length:346 Species:Drosophila melanogaster
Sequence 2:NP_006230.2 Gene:PPEF2 / 5470 HGNCID:9244 Length:753 Species:Homo sapiens


Alignment Length:364 Identity:98/364 - (26%)
Similarity:147/364 - (40%) Gaps:125/364 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    71 SAPVKICGDLHGQFKDLLRIFQQCGVP-PLSNYLFLGDYVDRGHCSIETLSLLLTYKLRYPETFF 134
            |..:.:|||||||..||:.||.:.|:| |..:|:|.||:||||..|:|.|.:|..:.|.||:.|.
Human   171 SEEITVCGDLHGQLDDLIFIFYKNGLPSPERSYVFNGDFVDRGKDSVEILMILFAFMLVYPKEFH 235

  Fly   135 LLRGNHESADLNRVYGFFDECKRRYSI---KLWRSFVDCYDCMPVAAIIADRIFCVHGGLS--PD 194
            |.|||||...:|..|||..|...:|.:   ::.|:..|.:..:|:|.:|.:::..:|||:|  .|
Human   236 LNRGNHEDHMVNLRYGFTKEVMNKYKVHGKEILRTLQDVFCWLPLATLIDEKVLILHGGVSDITD 300

  Fly   195 LNNLDDI------------------------RRLN------------------------------ 205
            |..||.|                        ||.|                              
Human   301 LELLDKIERSKIVSTMRCKTRQKSEKQMEEKRRANQKSSAQGPIPWFLPESRSLPSSPLRLGSYK 365

  Fly   206 -----RPTDVPSDGLL-------------------C----------------------------- 217
                 |.:.:|..|.|                   |                             
Human   366 AQKTSRSSSIPCSGSLDGRELSRQVRSSVELELERCRQQAGLLVTGEKEEPSRSASEADSEAGEL 430

  Fly   218 ------------DLLWSDPDETTGTWASNDRGVSFTFGANIVEGFLMQHKFNLIVRAHQVVEDGY 270
                        |:|||||....|..|:..||....||.::.:..|.::....::|:|:...:||
Human   431 RKPTQEEWRQVVDILWSDPMAQEGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGY 495

  Fly   271 EFFADRQLVTIFSAPNYCDIFDNCGAVLVVDAKLVCHFV 309
            ||..:|:::|||||.||.::..|.||.:.:...|..|.|
Human   496 EFCHNRKVLTIFSASNYYEVGSNRGAYVKLGPALTPHIV 534

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpD5NP_524707.1 PTZ00480 19..339 CDD:185658 98/364 (27%)
MPP_superfamily 25..313 CDD:301300 98/364 (27%)
PPEF2NP_006230.2 MPP_RdgC 122..537 CDD:277364 98/364 (27%)
Catalytic 128..540 98/364 (27%)
PP2Ac 141..540 CDD:197547 98/364 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 318..382 6/63 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 409..435 0/25 (0%)
EFh 657..722 CDD:238008
EF-hand_7 657..721 CDD:290234
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 732..753
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165141363
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0639
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000018
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.740

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