DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PpD5 and Ppp3cc

DIOPT Version :9

Sequence 1:	NP_524707.1	Gene:	PpD5 / 44148	FlyBaseID:	FBgn0005778	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_001291920.1	Gene:	Ppp3cc / 19057	MGIID:	107162	Length:	522	Species:	Mus musculus

Alignment Length:	337	Identity:	123/337 - (36%)
Similarity:	187/337 - (55%)	Gaps:	38/337 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SRRSTVLSTGKESSKEEKNRMSQLDVIIGQLKTMAVGNRRAGNLSEATITYICQASRELFLSQPM 66
            :||.|:    ||..:..|.:|.       .||...|   :.|.:.|.....|......:...:..
Mouse    23 TRRLTL----KEVFENGKPKMD-------LLKNHLV---KEGRVEEEVALKIINDGAAILKQEKT 73

  Fly    67 LLELSAPVKICGDLHGQFKDLLRIFQQCGVPPLSNYLFLGDYVDRGHCSIETLSLLLTYKLRYPE 131
            ::|:.||:.:|||:||||.||:::|:..|.|..:.|||||||||||:.|||.:..|.:.|:.:|:
Mouse    74 MIEVEAPITVCGDVHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLWSLKINHPK 138

  Fly   132 TFFLLRGNHESADLNRVYGFFDECKRRYSIKLWRSFVDCYDCMPVAAIIADRIFCVHGGLSPDLN 196
            |.||||||||...|...:.|..||:.:||..::.:.:..:||:|:||::..:..|||||:||::.
Mouse   139 TLFLLRGNHECRHLTEYFTFKQECRIKYSEMVYDACMHTFDCLPLAALLNQQFLCVHGGMSPEIT 203

  Fly   197 NLDDIRRLNRPTDVPSDGLLCDLLWSDPDETTGT------WASND-RGVSFTFGANIVEGFLMQH 254
            .|:|||:|:|.::.|:.|.:||||||||.|..|:      :..|. ||.|:.|....|..||..:
Mouse   204 CLEDIRKLDRFSEPPAFGPVCDLLWSDPLEDYGSEKTLEHYTHNTVRGCSYFFSYPAVCEFLQNN 268

  Fly   255 KFNLIVRAHQVVEDGYEFFADRQ------LVTIFSAPNYCDIFDNCGAVLVVDAKLV------CH 307
            ....|:|||:..:.||..:...|      |:||||||||.|:::|..|||..:..::      |
Mouse   269 SLLSIIRAHEAQDAGYRMYRKNQATGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNC- 332

  Fly   308 FVIIRPRPFSRP 319
                .|.|:..|
Mouse   333 ----SPHPYWLP 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PpD5	NP_524707.1	PTZ00480	19..339	CDD:185658	118/320 (37%)
PpD5	NP_524707.1	MPP_superfamily	25..313	CDD:301300	113/306 (37%)
Ppp3cc	NP_001291920.1	MPP_PP2B	37..341	CDD:277361	117/319 (37%)
		Catalytic. /evidence=ECO:0000305	52..343		112/294 (38%)
		PP2Ac	54..325	CDD:197547	108/270 (40%)
		SAPNY motif. /evidence=ECO:0000250\|UniProtKB:Q08209	303..307		3/3 (100%)
		Calcineurin B binding. /evidence=ECO:0000250\|UniProtKB:P16298	344..366
		Calmodulin-binding. /evidence=ECO:0000250\|UniProtKB:P16298	394..408
		Autoinhibitory segment. /evidence=ECO:0000250\|UniProtKB:P16298	409..416
		Autoinhibitory domain. /evidence=ECO:0000250\|UniProtKB:P16298	467..489
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	481..522
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53795
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820