DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PpD5 and Ppp3ca

DIOPT Version :9

Sequence 1:	NP_524707.1	Gene:	PpD5 / 44148	FlyBaseID:	FBgn0005778	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_032939.1	Gene:	Ppp3ca / 19055	MGIID:	107164	Length:	521	Species:	Mus musculus

Alignment Length:	327	Identity:	123/327 - (37%)
Similarity:	186/327 - (56%)	Gaps:	33/327 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 SSKE--EKNRMSQLDVIIGQLKTMAVGNRRAGNLSEATITYICQASRELFLSQPMLLELSAPVKI 76
            ::||  :.:...::|::...|       .:.|.|.|:....|......:...:..||::.|||.:
Mouse    30 TAKEVFDNDGKPRVDILKAHL-------MKEGRLEESVALRIITEGASILRQEKNLLDIDAPVTV 87

  Fly    77 CGDLHGQFKDLLRIFQQCGVPPLSNYLFLGDYVDRGHCSIETLSLLLTYKLRYPETFFLLRGNHE 141
            |||:||||.||:::|:..|.|..:.|||||||||||:.|||.:..|...|:.||:|.||||||||
Mouse    88 CGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHE 152

  Fly   142 SADLNRVYGFFDECKRRYSIKLWRSFVDCYDCMPVAAIIADRIFCVHGGLSPDLNNLDDIRRLNR 206
            ...|...:.|..|||.:||.:::.:.:|.:||:|:||::..:..||||||||::|.|||||:|:|
Mouse   153 CRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDR 217

  Fly   207 PTDVPSDGLLCDLLWSDPDETTGTWASND-------RGVSFTFGANIVEGFLMQHKFNLIVRAHQ 264
            ..:.|:.|.:||:|||||.|..|...:.:       ||.|:.:....|..||..:....|:|||:
Mouse   218 FKEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNTVRGCSYFYSYPAVCDFLQHNNLLSILRAHE 282

  Fly   265 VVEDGYEFFADRQ------LVTIFSAPNYCDIFDNCGAVLVVDAKLV------CHFVIIRPRPFS 317
            ..:.||..:...|      |:||||||||.|:::|..|||..:..::      |     .|.|:.
Mouse   283 AQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNC-----SPHPYW 342

  Fly   318 RP 319
            .|
Mouse   343 LP 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PpD5	NP_524707.1	PTZ00480	19..339	CDD:185658	121/320 (38%)
PpD5	NP_524707.1	MPP_superfamily	25..313	CDD:301300	118/306 (39%)
Ppp3ca	NP_032939.1	MPP_PP2B	41..345	CDD:277361	121/316 (38%)
		Catalytic. /evidence=ECO:0000305	56..340		116/288 (40%)
		SAPNY motif. /evidence=ECO:0000250\|UniProtKB:Q08209	307..311		3/3 (100%)
		Interaction with PxIxIF motif in substrate. /evidence=ECO:0000250\|UniProtKB:Q08209	327..336		0/8 (0%)
		Calcineurin B binding. /evidence=ECO:0000269\|PubMed:26794871	341..369		1/4 (25%)
		Calmodulin-binding. /evidence=ECO:0000269\|PubMed:26794871	392..406
		Autoinhibitory segment. /evidence=ECO:0000269\|PubMed:26794871	407..414
		Autoinhibitory domain. /evidence=ECO:0000269\|PubMed:26794871	465..487
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	475..521
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831303
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53795
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750