DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mkrn1 and MKRN3

DIOPT Version :9

Sequence 1:	NP_001246867.1	Gene:	Mkrn1 / 44131	FlyBaseID:	FBgn0029152	Length:	386	Species:	Drosophila melanogaster
Sequence 2:	NP_005655.1	Gene:	MKRN3 / 7681	HGNCID:	7114	Length:	507	Species:	Homo sapiens

Alignment Length:	352	Identity:	136/352 - (38%)
Similarity:	180/352 - (51%)	Gaps:	68/352 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 QTICRYYVRGICRFGELCRFSHDLSRGRPECEE------------------------QVATDVLP 60
            |.|||||:.|.|:.||.||:||||| ||....|                        |...:..|
Human    98 QIICRYYIHGQCKEGENCRYSHDLS-GRKMATEGGVSPPGASAGGGPSTAAHIEPPTQEVAEAPP 161

  Fly    61 KPSTSSSSTIGS---------------RSASISSQQRNWANAPVFVPSQK---RYTAHEQSEFET 107
            ..|:.|...|||               |.|:..:...:||:|..|||.|.   |:.|..
Human   162 AASSLSLPVIGSAAERGFFEAERDNADRGAAGGAGVESWADAIEFVPGQPYRGRWVASA------ 220

  Fly   108 TVDPEAVME-AQAGASYDTLAPGVSWAEVVGGPSSLNKEDYGEENSSCAWGEFSAYPIHMELCEM 171
               |||.:: ::.......:..|:.:.             |......|..||...| :|.::|:|
Human   221 ---PEAPLQSSETERKQMAVGSGLRFC-------------YYASRGVCFRGESCMY-LHGDICDM 268

  Fly   172 CDQYCLHPTDQVQRRSHNRECLQQHEQAMELSFAIARSKDKTCGICFDTIMEKAG-REKRFGILP 235
            |....|||.|..||..|.|.|::.||:.||||||:.|..||.||||.:.:.|||. .::|||||.
Human   269 CGLQTLHPMDAAQREEHMRACIEAHEKDMELSFAVQRGMDKVCGICMEVVYEKANPNDRRFGILS 333

  Fly   236 NCNHIFCLECIRTWRQAKQFENKITRACPECRVCSDFVCPSAFWMETKEEKDKLLNDYRAALGAK 300
            ||||.||:.|||.||.|:||||:|.::||:|||.|:.|.||.||:|.:|||.||:..|:.|:..|
Human   334 NCNHSFCIRCIRRWRSARQFENRIVKSCPQCRVTSELVIPSEFWVEEEEEKQKLIQQYKEAMSNK 398

  Fly   301 DCKYFKKGEGKCPFGNKCFYKHALPNG 327
            .|:||.:|.|.||||:.|||||..|.|
Human   399 ACRYFAEGRGNCPFGDTCFYKHEYPEG 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mkrn1	NP_001246867.1	ZnF_C3H1	20..43	CDD:214632	14/22 (64%)
Mkrn1	NP_001246867.1	RING	213..267	CDD:238093	31/54 (57%)
MKRN3	NP_005655.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..48
		DNA_pol3_gamma3	<33..232	CDD:331207	41/143 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	69..89
		ZnF_C3H1	95..121	CDD:214632	14/22 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	126..149		1/22 (5%)
		PHA02929	<252..400	CDD:331986	77/148 (52%)
		Makorin-type Cys-His	266..293		12/26 (46%)
		RING-HC_MKRN1_3	308..368	CDD:319644	36/59 (61%)
		RING-HC finger (C3HC4-type)	311..364	CDD:319644	31/52 (60%)
		MKRN1_C	439..505	CDD:318109
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	85	0.172	Domainoid score	I8156
eggNOG	1	0.900	-	-		E1_KOG1039
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3221
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58455
OrthoDB	1	1.010	-	-		D1388677at2759
OrthoFinder	1	1.000	-	-		FOG0000752
OrthoInspector	1	1.000	-	-		mtm8603
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11224
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X837
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.940