DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mkrn1 and Mkrn2

DIOPT Version :9

Sequence 1:	NP_001246867.1	Gene:	Mkrn1 / 44131	FlyBaseID:	FBgn0029152	Length:	386	Species:	Drosophila melanogaster
Sequence 2:	NP_075779.2	Gene:	Mkrn2 / 67027	MGIID:	1914277	Length:	416	Species:	Mus musculus

Alignment Length:	418	Identity:	139/418 - (33%)
Similarity:	213/418 - (50%)	Gaps:	67/418 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LGRSQTICRYYVRGICRFGELCRFSHDLSRGRPE--CE---------------------EQVATD 57
            :...|..|||::.|:||.|..|.|||||:..:|.  |:                     ......
Mouse     1 MSTKQVTCRYFMHGVCREGSQCLFSHDLANSKPSTICKYYQKGYCAYGARCRYDHTKPPAAAGGA 65

  Fly    58 VLPKPSTSSSSTIGSRSAS---ISSQQRNWANAP------VFVPSQKRYTAHEQSEFETT----- 108
            |.|.|:.|.||.:.|...|   .:|..|..:|.|      ..|...:..|...:.:...:
Mouse    66 VGPAPNPSPSSGLHSPHPSPDIATSVMRTHSNEPGKREKKTLVLRDRNLTGLAEDKTPPSKVNNP 130

  Fly   109 ---VDPEAVMEAQAGASYDTLAPGVSWAEVVGGPSSLNKEDY-------GEENSSCAWGEFSAYP 163
               .||:...|.:..:..|.:..|:...|   ..||.:.|..       ||    |.:|:...|
Mouse   131 GGCSDPQTSPEMKPHSYLDAIRTGLDDLE---ASSSYSNEPQLCPYAAAGE----CRFGDACVY- 187

  Fly   164 IHMELCEMCDQYCLHPTDQVQRRSHNRECLQQHEQAMELSFAIARSKDKTCGICFDTIMEKA-GR 227
            :|.::||:|....|||.|..||::|.:.|:...|..||.:||...|:||.|.||.:.|:||| ..
Mouse   188 LHGDMCEICRLQVLHPFDPEQRKAHEKMCMSTFEHEMEKAFAFQASQDKVCSICMEVILEKASAS 252

  Fly   228 EKRFGILPNCNHIFCLECIRTWRQAKQFENKITRACPECRVCSDFVCPSAFWMETKEEKDKLLND 292
            |:|||||.||:|.:||.|||.||.||||||.|.::||||||.|:||.||.:|:|.:.:|::|:..
Mouse   253 ERRFGILSNCSHTYCLSCIRQWRCAKQFENPIIKSCPECRVISEFVIPSVYWVEDQNKKNELIEA 317

  Fly   293 YRAALGAKDCKYFKKGEGKCPFGNKCFYKHALPNGDIVDVGLPKRTRK-LQSQNEIIDLLDIYLW 356
            ::..:|.|.||||::|:|.||||:||.|:||.|:|.:.:   |::.|| |.|:..:.....:.||
Mouse   318 FKQGMGKKACKYFEQGKGTCPFGSKCLYRHAYPDGRLAE---PEKPRKQLSSEGTVRFFNSVRLW 379

  Fly   357 DYVDRRDYHWLEMISSDITSSESSDYSD 384
            |:::.|:       :..:.|::..|.::
Mouse   380 DFIENRE-------TRQVPSTDDVDVTE 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mkrn1	NP_001246867.1	ZnF_C3H1	20..43	CDD:214632	12/22 (55%)
Mkrn1	NP_001246867.1	RING	213..267	CDD:238093	33/54 (61%)
Mkrn2	NP_075779.2	ZnF_C3H1	2..28	CDD:214632	12/25 (48%)
		ZnF_C3H1	35..55	CDD:214632	1/19 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	61..144		17/82 (21%)
		PHA03096	<178..327	CDD:222981	71/153 (46%)
		Makorin-type Cys-His	193..222		11/28 (39%)
		RING	238..292	CDD:238093	33/53 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	85	1.000	Domainoid score	I8159
eggNOG	1	0.900	-	-		E1_KOG1039
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	254	1.000	Inparanoid score	I3177
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58455
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000752
OrthoInspector	1	1.000	-	-		mtm8837
orthoMCL	1	0.900	-	-		OOG6_103641
Panther	1	1.100	-	-	O	PTHR11224
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X837
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.830