DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mkrn1 and mkrn2

DIOPT Version :9

Sequence 1:	NP_001246867.1	Gene:	Mkrn1 / 44131	FlyBaseID:	FBgn0029152	Length:	386	Species:	Drosophila melanogaster
Sequence 2:	NP_001005447.1	Gene:	mkrn2 / 448038	XenbaseID:	XB-GENE-5879487	Length:	418	Species:	Xenopus tropicalis

Alignment Length:	389	Identity:	128/389 - (32%)
Similarity:	192/389 - (49%)	Gaps:	59/389 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 CRYYVRGICRFGELCRFSHDLSRGRPE------------------------CEEQV---ATDVLP 60
            |||::.|:||.|..|.|||||:..:|.                        |...|   ..::.|
Frog     8 CRYFLHGVCREGGRCLFSHDLATSKPSTVCRFYQRGQCAYGARCRYDHVKPCNGSVFYPPQEMAP 72

  Fly    61 KPSTSSSSTIGSRSASI----SSQQRNWANAPVF---------------VPSQKRYTAHEQSEFE 106
            .|..|:...:.::.|:.    |:.||....:.|.               .|:.:...|.:....|
Frog    73 APLESTPPLLPTQEAAAPVTKSAPQRREKKSVVLRDRDLCGASVEKAHPDPALRPGCAADPPVSE 137

  Fly   107 TTVDPEAVMEAQAGASYDTLAPGVSWAEVVGGPSSLNKEDYGEENSSCAWGEFSAYPIHMELCEM 171
            ....|.:.:||......:|..|...       |.:..:.....:...|.:||...| ||..:||:
Frog   138 LEAKPHSYLEAICTGLDETPIPSAY-------PDAPQQLCPFAQAGGCHYGESCPY-IHGNVCEI 194

  Fly   172 CDQYCLHPTDQVQRRSHNRECLQQHEQAMELSFAIARSKDKTCGICFDTIMEK-AGREKRFGILP 235
            |....|||.||.||..|.:.|:...|:.||.:||...|:.|.|.||.:.:.:| :..|:|||||.
Frog   195 CGLQVLHPYDQEQRGHHEKLCMANFERDMERAFAFQASEGKVCSICMERVYDKQSPSERRFGILS 259

  Fly   236 NCNHIFCLECIRTWRQAKQFENKITRACPECRVCSDFVCPSAFWMETKEEKDKLLNDYRAALGAK 300
            ||:|.:||.|||.||.|:||||.:.::||||||.|:||.|||:|:|.:.:|.:|:..::..:|.|
Frog   260 NCHHTYCLACIRQWRCARQFENPVIKSCPECRVISEFVIPSAYWVEDQSKKFELIEAFKQGMGKK 324

  Fly   301 DCKYFKKGEGKCPFGNKCFYKHALPNGDIVDVGLPKRTRK-LQSQNEIIDLLDIYLWDYVDRRD 363
            .||||.:|.|.||||.||.|.||.|:|...:   |::.|| |.|:..:..|..:.|||:::.|:
Frog   325 ACKYFDQGRGTCPFGGKCLYLHAYPDGTRAE---PEKPRKQLGSEGTVRFLNSVRLWDFIEERE 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mkrn1	NP_001246867.1	ZnF_C3H1	20..43	CDD:214632	11/19 (58%)
Mkrn1	NP_001246867.1	RING	213..267	CDD:238093	28/54 (52%)
mkrn2	NP_001005447.1	YTH1	<5..>80	CDD:227416	19/71 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	76..100		5/23 (22%)
		PHA03096	<178..310	CDD:222981	64/132 (48%)
		Makorin-type Cys-His. /evidence=ECO:0000255	192..221		12/28 (43%)
		RING-HC_MKRN2	234..291	CDD:319645	29/56 (52%)
		RING-HC finger (C3HC4-type)	237..290	CDD:319645	27/52 (52%)
		MKRN1_C	360..>412	CDD:374139	9/26 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	91	1.000	Domainoid score	I7557
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	251	1.000	Inparanoid score	I3142
OMA	1	1.010	-	-		QHG58455
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000752
OrthoInspector	1	1.000	-	-		mtm9499
Panther	1	1.100	-	-	O	PTHR11224
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X837
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	10.070