DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mkrn1 and CG12477

DIOPT Version :9

Sequence 1:	NP_001246867.1	Gene:	Mkrn1 / 44131	FlyBaseID:	FBgn0029152	Length:	386	Species:	Drosophila melanogaster
Sequence 2:	NP_649055.1	Gene:	CG12477 / 40040	FlyBaseID:	FBgn0036809	Length:	265	Species:	Drosophila melanogaster

Alignment Length:	338	Identity:	138/338 - (40%)
Similarity:	181/338 - (53%)	Gaps:	86/338 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 EEQVATDVLPKPSTSSSSTIGSRSASISSQQRNWANAPVFVPSQKRYTAHEQSEFETTVDPEAVM 115
            ::.|.|.|||.|||:|.|       |...|:.|.|    .||:.|..||.||.
  Fly     8 DQHVDTGVLPVPSTNSPS-------SQIEQKGNEA----IVPNYKAATAGEQG------------ 49

  Fly   116 EAQAGASYDTLA---PGVSW-AEVVGGPSSLNKEDYGEENSSCAWGEFSAYPIHMELCEMCDQYC 176
            ||||||:..|:|   .||:. |::|.|.||::.                    |:
  Fly    50 EAQAGATCTTVAVRPSGVATSADIVKGSSSVSS--------------------HV---------- 84

  Fly   177 LHPTDQVQRRSHNRECLQQHEQAMELSFAIARSKDKTCGICFDTIMEKAGREKRFGILPNCNHIF 241
                 |...||                 :.|||:||.|||||:|||||.|.:|||||||:|||:|
  Fly    85 -----QPSWRS-----------------SFARSQDKKCGICFETIMEKEGGDKRFGILPSCNHVF 127

  Fly   242 CLECIRTWRQAKQFENKITRACPECRVCSDFVCPSAFWMETKEEKDKLLNDYRAALGAKDCKYFK 306
            |.:||.|||.|.|:..::|||||||||.|:||||||||:|.|..||:|:||:.||:.|:||||||
  Fly   128 CFQCICTWRHATQYAYQVTRACPECRVWSNFVCPSAFWVEEKVAKDQLINDHLAAMRARDCKYFK 192

  Fly   307 KGEGKCPFGNKCFYKHALPNGDIVDVGLPKRTRKLQSQNEIIDLLDIYLWDYVDRRDYHWLEMIS 371
            :|:|.|.|||||||||::||.|.||||||.....|...::...|.:..:.       ..:..|..
  Fly   193 QGQGVCLFGNKCFYKHSIPNADYVDVGLPTHALGLPIPSDFSGLGNCLIL-------VPFPNMFF 250

  Fly   372 SDITSSESSDYSD 384
            .|.::|:..|:||
  Fly   251 DDFSNSDDYDFSD 263

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mkrn1	NP_001246867.1	ZnF_C3H1	20..43	CDD:214632
Mkrn1	NP_001246867.1	RING	213..267	CDD:238093	36/53 (68%)
CG12477	NP_649055.1	RING	99..153	CDD:238093	36/53 (68%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45448395
Domainoid	1	1.000	75	1.000	Domainoid score	I3185
eggNOG	1	0.900	-	-		E1_KOG1039
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	171	1.000	Inparanoid score	I1531
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D116581at6656
OrthoFinder	1	1.000	-	-		FOG0000752
OrthoInspector	1	1.000	-	-		mtm1123
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11224
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.900