DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mkrn1 and Mkrn2

DIOPT Version :9

Sequence 1:	NP_001246867.1	Gene:	Mkrn1 / 44131	FlyBaseID:	FBgn0029152	Length:	386	Species:	Drosophila melanogaster
Sequence 2:	NP_001008315.1	Gene:	Mkrn2 / 297525	RGDID:	1310618	Length:	417	Species:	Rattus norvegicus

Alignment Length:	419	Identity:	142/419 - (33%)
Similarity:	216/419 - (51%)	Gaps:	68/419 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LGRSQTICRYYVRGICRFGELCRFSHDLSRGRPE--CE---------------------EQVATD 57
            :...|..|||::.|:||.|..|.|||||:..:|.  |:                     ......
  Rat     1 MSTKQVTCRYFMHGVCREGSQCLFSHDLANSKPSTICKYYQKGYCAYGARCRYDHTKPPAAAGGA 65

  Fly    58 VLPKPSTSSSSTIGSRSAS---ISSQQRNWANAP------VFVPSQKRYT--AHEQSEFETTV-- 109
            |.|.|..|.||.:.|...|   .:|..|..:|.|      ..|...:..|  |.:::...:||
  Rat    66 VGPAPHPSPSSGLHSPHPSSDIATSVMRTHSNEPRKREKKTLVLRDRNLTGLAEDKTPPPSTVNN 130

  Fly   110 -----DPEAVMEAQAGASYDTLAPGVSWAEVVGGPSSLNKEDY-------GEENSSCAWGEFSAY 162
                 ||:...|.:..:..|.:..|:...|   ..||.:.|..       ||    |.:|:...|
  Rat   131 PGGCNDPQTSPEMKPHSYLDAIRTGLDDLE---ASSSYSNEQQLCPYAAAGE----CRFGDACVY 188

  Fly   163 PIHMELCEMCDQYCLHPTDQVQRRSHNRECLQQHEQAMELSFAIARSKDKTCGICFDTIMEKA-G 226
             :|.::||:|....|||.|..||::|.:.|:...|..||.:||...|:||.|.||.:.|:||| .
  Rat   189 -LHGDMCEICRLQVLHPFDPEQRKAHEKMCMSTFEHEMEKAFAFQASQDKVCSICMEVILEKASA 252

  Fly   227 REKRFGILPNCNHIFCLECIRTWRQAKQFENKITRACPECRVCSDFVCPSAFWMETKEEKDKLLN 291
            .|:|||||.||:|.:||.|||.||.||||||.|.::||||||.|:||.||.:|:|.:.:|::|:.
  Rat   253 SERRFGILSNCSHTYCLSCIRQWRCAKQFENPIIKSCPECRVISEFVIPSVYWVEDQNKKNELIE 317

  Fly   292 DYRAALGAKDCKYFKKGEGKCPFGNKCFYKHALPNGDIVDVGLPKRTRK-LQSQNEIIDLLDIYL 355
            .::..:|.|.||||::|:|.||||:||.|:||.|:|.:.:   |::.|| |.|:..:.....:.|
  Rat   318 AFKQGMGKKACKYFEQGKGTCPFGSKCLYRHAYPDGRLAE---PEKPRKQLSSEGTVRFFNSVRL 379

  Fly   356 WDYVDRRDYHWLEMISSDITSSESSDYSD 384
            ||:::.|:       :..:.|::..|.::
  Rat   380 WDFIENRE-------TRQVPSTDDVDVTE 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mkrn1	NP_001246867.1	ZnF_C3H1	20..43	CDD:214632	12/22 (55%)
Mkrn1	NP_001246867.1	RING	213..267	CDD:238093	33/54 (61%)
Mkrn2	NP_001008315.1	zf-CCCH_4	6..27	CDD:407881	10/20 (50%)
		zf_CCCH_4	37..55	CDD:408151	1/17 (6%)
		PHA03096	<179..328	CDD:222981	71/153 (46%)
		RING-HC_MKRN2	236..293	CDD:319645	35/56 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	85	1.000	Domainoid score	I7980
eggNOG	1	0.900	-	-		E1_KOG1039
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	254	1.000	Inparanoid score	I3107
OMA	1	1.010	-	-		QHG58455
OrthoDB	1	1.010	-	-		D1388677at2759
OrthoFinder	1	1.000	-	-		FOG0000752
OrthoInspector	1	1.000	-	-		mtm9084
orthoMCL	1	0.900	-	-		OOG6_103641
Panther	1	1.100	-	-	O	PTHR11224
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X837
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840