DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mkrn1 and Mkrn1

DIOPT Version :9

Sequence 1:	NP_001246867.1	Gene:	Mkrn1 / 44131	FlyBaseID:	FBgn0029152	Length:	386	Species:	Drosophila melanogaster
Sequence 2:	XP_006236363.1	Gene:	Mkrn1 / 296988	RGDID:	1303251	Length:	481	Species:	Rattus norvegicus

Alignment Length:	425	Identity:	156/425 - (36%)
Similarity:	217/425 - (51%)	Gaps:	106/425 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 QTICRYYVRGICRFGELCRFSHDLS------------RG-------------RPECEEQV-ATDV 58
            |..|||::.|:|:.|:.||:|||||            ||             :|..:|:| |||:
  Rat    58 QVTCRYFMHGVCKEGDNCRYSHDLSDSPYGVVCKYFQRGYCVYGDRCRYEHSKPLKQEEVTATDL 122

  Fly    59 LPKPSTSSSSTIGSRSASIS------SQQRN------------WANAPVFVPSQ----------- 94
            ..|||.::||::.|...|::      ::.||            |.||..|||.|
  Rat   123 SAKPSPAASSSLPSGVGSLAEMNPGEAESRNPNFPTVGAGSEDWVNAIEFVPGQPYCGRTAPSCT 187

  Fly    95 ----KRYTAHEQSEFE-TTVDPEAVMEAQAGASYDTLAPGVSWAEVVGGPSSLNKEDYGEENSSC 154
                :.....|:||.| |||:.|           ..|.|   :|.|            ||    |
  Rat   188 EVPLQGSVTKEESEKEPTTVETE-----------KQLCP---YAAV------------GE----C 222

  Fly   155 AWGEFSAYPIHMELCEMCDQYCLHPTDQVQRRSHNRECLQQHEQAMELSFAIARSKDKTCGICFD 219
            .:||...| :|.:.|:||....|||.|..||..|.:.|::.||:.||||||:.||||..||||.:
  Rat   223 RYGENCVY-LHGDSCDMCGLQVLHPMDAAQRSQHIKSCIEAHEKDMELSFAVQRSKDMVCGICME 286

  Fly   220 TIMEKAG-REKRFGILPNCNHIFCLECIRTWRQAKQFENKITRACPECRVCSDFVCPSAFWMETK 283
            .:.|||. .|:|||||.||||.:||:|||.||.|||||:||.::|||||:.|:||.||.:|:|.|
  Rat   287 VVYEKANPSERRFGILSNCNHTYCLKCIRKWRSAKQFESKIIKSCPECRITSNFVIPSEYWVEEK 351

  Fly   284 EEKDKLLNDYRAALGAKDCKYFKKGEGKCPFGNKCFYKHALPNGDIVD-----VGLPKRTRKLQS 343
            |||.||:..|:.|:..|.|:||.:|.|.||||..||||||.|:|...:     ||...|.|..:.
  Rat   352 EEKQKLIQKYKEAMSNKACRYFDEGRGSCPFGGNCFYKHAYPDGRREEPQRQKVGTSSRYRAQRR 416

  Fly   344 QNEIIDLLDIYLWDYVDRRDYHWLEMISSDITSSE 378
            .         :.|:.::.|:.:..:....::.:.|
  Rat   417 S---------HFWELIEERENNPFDNDEEEVVTFE 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mkrn1	NP_001246867.1	ZnF_C3H1	20..43	CDD:214632	11/22 (50%)
Mkrn1	NP_001246867.1	RING	213..267	CDD:238093	34/54 (63%)
Mkrn1	XP_006236363.1	ZnF_C3H1	55..81	CDD:214632	11/22 (50%)
		ZnF_C3H1	88..110	CDD:214632	10/22 (45%)
		PHA03096	<221..370	CDD:222981	85/154 (55%)
		RING	281..335	CDD:238093	32/53 (60%)
		MKRN1_C	400..479	CDD:292443	2/17 (12%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	86	1.000	Domainoid score	I7889
eggNOG	1	0.900	-	-		E1_KOG1039
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	254	1.000	Inparanoid score	I3107
OMA	1	1.010	-	-		QHG58455
OrthoDB	1	1.010	-	-		D1388677at2759
OrthoFinder	1	1.000	-	-		FOG0000752
OrthoInspector	1	1.000	-	-		mtm9084
orthoMCL	1	0.900	-	-		OOG6_103641
Panther	1	1.100	-	-	LDO	PTHR11224
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X837
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840