DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mkrn1 and MKRN2

DIOPT Version :9

Sequence 1:	NP_001246867.1	Gene:	Mkrn1 / 44131	FlyBaseID:	FBgn0029152	Length:	386	Species:	Drosophila melanogaster
Sequence 2:	NP_054879.3	Gene:	MKRN2 / 23609	HGNCID:	7113	Length:	416	Species:	Homo sapiens

Alignment Length:	422	Identity:	141/422 - (33%)
Similarity:	216/422 - (51%)	Gaps:	75/422 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LGRSQTICRYYVRGICRFGELCRFSHDLSRGRP----------------ECEEQVATDVLPKPST 64
            :...|..|||::.|:||.|..|.|||||:..:|                .|.....     :||.
Human     1 MSTKQITCRYFMHGVCREGSQCLFSHDLANSKPSTICKYYQKGYCAYGTRCRYDHT-----RPSA 60

  Fly    65 SSSSTIGSRSASISSQQRNWANAPVFV-PSQKRYTAHE--QSEFETTV----------------- 109
            ::...:|:.:.|:.|...:..:.|..| .|..:..:||  :.|..|.|
Human    61 AAGGAVGTMAHSVPSPAFHSPHPPSEVTASIVKTNSHEPGKREKRTLVLRDRNLSGMAERKTQPS 125

  Fly   110 ---------DPEAVMEAQAGASYDTLAPGVSWAEVVGGPSSLNKEDY------GEENSSCAWGEF 159
                     ||:...|.:..:..|.:..|:.  :|....|..|::..      ||    |.:|:.
Human   126 MVSNPGSCSDPQPSPEMKPHSYLDAIRSGLD--DVEASSSYSNEQQLCPYAAAGE----CRFGDA 184

  Fly   160 SAYPIHMELCEMCDQYCLHPTDQVQRRSHNRECLQQHEQAMELSFAIARSKDKTCGICFDTIMEK 224
            ..| :|.|:||:|....|||.|..||::|.:.|:...|..||.:||...|:||.|.||.:.|:||
Human   185 CVY-LHGEVCEICRLQVLHPFDPEQRKAHEKICMLTFEHEMEKAFAFQASQDKVCSICMEVILEK 248

  Fly   225 A-GREKRFGILPNCNHIFCLECIRTWRQAKQFENKITRACPECRVCSDFVCPSAFWMETKEEKDK 288
            | ..|:|||||.||||.:||.|||.||.||||||.|.::||||||.|:||.||.:|:|.:.:|::
Human   249 ASASERRFGILSNCNHTYCLSCIRQWRCAKQFENPIIKSCPECRVISEFVIPSVYWVEDQNKKNE 313

  Fly   289 LLNDYRAALGAKDCKYFKKGEGKCPFGNKCFYKHALPNGDIVDVGLPKRTRK-LQSQNEIIDLLD 352
            |:..::..:|.|.||||::|:|.||||:||.|:||.|:|.:.:   |::.|| |.||..:.....
Human   314 LIEAFKQGMGKKACKYFEQGKGTCPFGSKCLYRHAYPDGRLAE---PEKPRKQLSSQGTVRFFNS 375

  Fly   353 IYLWDYVDRRDYHWLEMISSDITSSESSDYSD 384
            :.|||:::.|:       |..:.::|..|.::
Human   376 VRLWDFIENRE-------SRHVPNNEDVDMTE 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mkrn1	NP_001246867.1	ZnF_C3H1	20..43	CDD:214632	12/22 (55%)
Mkrn1	NP_001246867.1	RING	213..267	CDD:238093	34/54 (63%)
MKRN2	NP_054879.3	ZnF_C3H1	2..28	CDD:214632	12/25 (48%)
		ZnF_C3H1	35..55	CDD:214632	1/19 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	113..142		2/28 (7%)
		PHA03096	<178..327	CDD:222981	73/153 (48%)
		Makorin-type Cys-His	193..222		11/28 (39%)
		RING	238..292	CDD:238093	34/53 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	85	0.172	Domainoid score	I8156
eggNOG	1	0.900	-	-		E1_KOG1039
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3221
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58455
OrthoDB	1	1.010	-	-		D1388677at2759
OrthoFinder	1	1.000	-	-		FOG0000752
OrthoInspector	1	1.000	-	-		mtm8603
orthoMCL	1	0.900	-	-		OOG6_103641
Panther	1	1.100	-	-	O	PTHR11224
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X837
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.840