DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mkrn1 and mkrn2

DIOPT Version :9

Sequence 1:	NP_001246867.1	Gene:	Mkrn1 / 44131	FlyBaseID:	FBgn0029152	Length:	386	Species:	Drosophila melanogaster
Sequence 2:	NP_694511.1	Gene:	mkrn2 / 170783	ZFINID:	ZDB-GENE-020213-2	Length:	414	Species:	Danio rerio

Alignment Length:	415	Identity:	132/415 - (31%)
Similarity:	210/415 - (50%)	Gaps:	75/415 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LGRSQTICRYYVRGICRFGELCRFSHDLSRGRPE--CE----------EQVATDVLPKPSTSSSS 68
            :...|..|||::.|:||.|..|.|||||:..:|.  |:          ::...|.:..|...|.:
Zfish     1 MSTKQVTCRYFLHGVCREGSRCLFSHDLTTSKPSTICKYYQRGACAYGDRCRYDHIKPPGRGSGA 65

  Fly    69 TIGSRSASISSQQRNWANAPVFVP----------------------SQKRYTAHEQSE----FET 107
            .....:.|.||.   .|:||...|                      |:.|..:.|.||    :|.
Zfish    66 PADHSNRSSSSA---GASAPGPGPPANTSKHLKKPLVLRDKALCSDSRPRVFSAESSELSECWEQ 127

  Fly   108 TVD----PEAVMEA-QAG--ASYDTLAPGVSWAEVVGGPSSLNKEDYGEENS----------SCA 155
            ..|    |.:.:|| ::|  ||....|...::.|:             ::.|          .|.
Zfish   128 RDDGAQKPHSYLEAIRSGLDASAAAAATAGTFPEL-------------QQTSPQICPFLAAGQCQ 179

  Fly   156 WGEFSAYPIHMELCEMCDQYCLHPTDQVQRRSHNRECLQQHEQAMELSFAIARSKDKTCGICFDT 220
            :||...| :|.|:||:|.|:.|||.|..||.:|.::|:...|..||.:||:.:|:||.|.||.|.
Zfish   180 YGESCPY-LHGEMCEICRQHVLHPHDPEQRAAHEKKCMVAFEMDMERAFAVQQSQDKVCKICLDV 243

  Fly   221 IMEKAG-REKRFGILPNCNHIFCLECIRTWRQAKQFENKITRACPECRVCSDFVCPSAFWMETKE 284
            :.||:. .|:|||||.:|.|.:||.|||.||..:|..|:|.::||||||.|:||.||.:|:|.:|
Zfish   244 VYEKSSPSERRFGILSSCAHTYCLNCIRQWRCVEQLHNQIRKSCPECRVVSEFVIPSIYWVEDQE 308

  Fly   285 EKDKLLNDYRAALGAKDCKYFKKGEGKCPFGNKCFYKHALPNGDIVDVGLPKRTRKLQSQNEIID 349
            :|:.|:.::::.:..|.||||.:|.|.||||.||||.||..:|...:...|:  ::|.::..:..
Zfish   309 QKNLLIEEFKSGVSKKACKYFDQGRGTCPFGGKCFYMHAYADGRRAEPDKPR--KQLSAEGNVRF 371

  Fly   350 LLDIYLWDYVDRRDYHWLEMISSDI 374
            ...:.|||:::.|::..:..:..::
Zfish   372 QNSVRLWDFIEEREHRSVPQLEDEV 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mkrn1	NP_001246867.1	ZnF_C3H1	20..43	CDD:214632	12/22 (55%)
Mkrn1	NP_001246867.1	RING	213..267	CDD:238093	27/54 (50%)
mkrn2	NP_694511.1	ZnF_C3H1	2..28	CDD:214632	12/25 (48%)
		ZnF_C3H1	35..57	CDD:214632	2/21 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	57..94		9/39 (23%)
		PHA03096	<178..326	CDD:222981	67/148 (45%)
		Makorin-type Cys-His	192..221		12/28 (43%)
		RING	237..291	CDD:238093	27/53 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	91	1.000	Domainoid score	I7675
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	253	1.000	Inparanoid score	I3175
OMA	1	1.010	-	-		QHG58455
OrthoDB	1	1.010	-	-		D1388677at2759
OrthoFinder	1	1.000	-	-		FOG0000752
OrthoInspector	1	1.000	-	-		mtm6616
orthoMCL	1	0.900	-	-		OOG6_103641
Panther	1	1.100	-	-	O	PTHR11224
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X837
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.940